Nifuroxazide official instructions. Suspension "Nifuroxazide" for children: instructions for use

Diarrhea is a symptom characterized by the appearance loose stool, increased gastrointestinal motility intestinal tract, discomfort in the abdominal area. Often such disorders are associated with penetration pathogenic microorganisms and their reproduction in the lumen of the gastrointestinal tract. It has its own characteristics in children due to rapid dehydration of the body and the occurrence of associated complications. Let's figure out how to cope with stool disorders using the drug "Nifuroxazide" for a child.

Pharmacological features

Nifuroxazide is an antimicrobial drug from the nitrofuran group, primarily used as an intestinal antiseptic. The mechanism of action of this drug is based on the inhibition of dehydrogenases and cellular respiration.

In addition, “Nifuroxazide” disrupts the processes of protein synthesis in the cell, thereby disrupting the vital activity of the microorganism.

Pharmacodynamics

When taken orally, the drug has low bioavailability, that is, it is practically not absorbed into the systemic circulation. Trace concentrations of nifuroxazide may be detected in blood plasma, while a small amount is excreted unchanged in urine. The rest is allocated with feces. In view of practically complete absence absorption, the rate of elimination of the drug depends on the dose taken and the intensity of intestinal motility.

Spectrum of action of the drug

Being a nitrofuran derivative, Nifuroxazide has a bacteriostatic effect in average therapeutic concentrations, and in more high doses acts as a bactericidal drug with slow development of resistance. A fairly large number of both gram-positive (streptococci, penicillinase-producing staphylococci) and gram-negative microorganisms (Escherichia coli, salmonella, shigella, klebsiella, enterobacteria) are sensitive to the drug. In addition, the medication negatively affects various viruses, Trichomonas, Giardia and Candida fungi. The drug retains its effect in the presence of pus and other products of tissue decay in the wound.

Nifuroxazide is ineffective in the treatment of pseudomonas infections, as well as infections caused by microorganisms of the genus Proteus.

Indications for use of the drug "Nifuroxazide" (instructions for children)

The main indication for prescribing the drug is various types of intestinal infections caused by pathogens sensitive to the antibacterial drug. "Nifuroxazide" is prescribed for acute stool disorder of infectious origin, chronic inflammatory diseases intestines and enterocolitis. The drug is prescribed to patients with infected wounds (local use of the drug is possible), as well as during surgical interventions on the intestines (for sanitation) and in the complex treatment of dysbiosis.

It should be noted that in pediatric practice the most commonly used medicine for is "Nifuroxazide". Instructions for children, with the exception of dosage, are similar to those for adults.

Directions for use and doses

The drug is used regardless of food intake. For the treatment of adults, as well as children after the age of seven, the drug is taken 1 tablet (200 mg) three or four times a day. This dose per dose corresponds to 5 ml of Nifuroxazide suspension or syrup. Instructions for use for children and adults indicate that after stool normalization, the drug should be continued for 3-4 days. The course of treatment should not exceed a week. If the drug is ineffective for a long time, the approach to therapy must be reconsidered.

For children preschool age the dosage should be reduced to 100-150 mg per dose of the drug "Nifuroxazide". Syrup for children is an excellent treatment option. At the same time, the frequency of use of the product remains the same. If you don’t have the medicine in syrup form on hand, you can gently crush half a 200 mg tablet between two tablespoons to a powdery consistency and give it to your baby with a little water or breast milk. In all other cases, it is recommended to use liquid Nifuroxazide (suspension for children).

Side effects

When using drugs from the nitrofuran group, the most common side effects occur: digestive tract, which is directly related to the site of action of the drug. When taking the drug "Nifuroxazide" for a child, there is a risk of developing dyspeptic disorders, cholestasis, and hepatitis. With a low degree of probability, there may be a reaction of individual intolerance to the drug by patients, which is accompanied by nausea, vomiting, abdominal pain, and diarrhea. In the latter case, with a slight exacerbation of symptoms, treatment should not be stopped, since negative manifestations quickly pass and are associated with the onset of action of the medication. If severe symptoms are present and the patient’s general well-being deteriorates, the drug should be discontinued.

The undesirable effect of the drug on the central nervous system is marked by the appearance of neuritis. Allergic reactions manifest themselves in the form of skin rash, itching, urticaria, and pustulosis. In severe cases, hypersensitivity reactions may occur, including anaphylactic shock or angioedema. Taking the drug is rarely accompanied by disorders of the hematopoietic system.

Special instructions for taking the drug

Let us remind you that therapy using the drug "Nifuroxazide" should not last more than 7 days. In the case of persistent pain that cannot be stopped within three days, it is necessary to reconsider the treatment tactics in the direction of prescribing antibiotics. In case of severe diarrhea and the presence of symptoms of dehydration, rehydration therapy and concomitant symptomatic treatment are carried out in parallel with the prescription of Nifuroxazide.

The drug contains lactose, so for patients suffering from impaired digestion of this substance, the use of the drug should be limited or completely stopped. While taking Nifuroxazide, it is not recommended to prescribe other oral medications due to a decrease in their effectiveness, which is associated with the presence of sorption properties active substance. When using the medication, drinking alcohol is contraindicated, as this can lead to the occurrence of disorders that are accompanied by disorders of the central nervous system. nervous system(noise and ringing in the ears), hyperemia of the skin, tachycardia, a feeling of fear.

According to official information according to the drug "Nifuroxazide" (instructions), suspension for children and syrup can reduce the manifestation adverse reactions from the intestines.

Use during pregnancy and lactation

There is no clear data indicating that taking the drug during pregnancy and breastfeeding is harmful. Considering that Nifuroxazide is not absorbed from the lumen gastrointestinal tract and does not pass into breast milk, the prescription of such a drug is possible if the potential positive effect for the mother's body is higher than the effect on the fetus.

Poisoning and overdose

Due to low bioavailability, symptoms of poisoning are unknown. When taking large doses of the drug, it is recommended to lavage the stomach and immediately seek qualified medical help.

Release form

On the pharmaceutical market, Nifuroxazide is available in the form of an oral suspension (200 or 220 mg of active substance in 5 ml of suspension, 90 ml bottle), tablets for oral use (100 or 200 mg in 1 tablet) or capsules (200 mg each). mg of the drug in 1 capsule). Each patient can choose the appropriate release form for himself.

In what form is Nifuroxazide most often purchased? Syrup for children is more in demand, since children are more often susceptible to intestinal infections.

Synonyms

The drug is also available under the names “Enterofuril”, “Ercefuril” in the form of capsules (100 or 200 mg each) and an oral suspension containing 200 mg of the active substance (nifuroxazide) per 5 ml. Instructions for use of analogues for children are practically no different from the original. However, before using the medicine, it should still be carefully studied.

"Nifuroxazide" for children: reviews

This drug is used not only in pediatrics, but also in the practice of internal medicine. Almost all reviews about the use of Nifuroxazide in children are positive. This is due to its effectiveness in the treatment of various types of disorders of the gastrointestinal tract, as well as the presence of conveniently dosed forms of the drug in the form of suspension and syrup.

In addition, Nifuroxazide is a fairly safe drug for children, which leads to its widespread use in clinical practice.

Conclusion

"Nifuroxazide" for a child is the maximum effective drug, which helps to quickly cope with diarrhea of ​​infectious origin. The safety of the drug is due to its low bioavailability, and its high effectiveness is due to its action only in the lumen of the gastrointestinal tract. According to official information on the drug "Nifuroxazide" (instructions), suspension for children and syrup are the more preferable forms. Tablets, as a rule, are prescribed to adults.

NIFUROXAZIDUM RICHTER

NIFUROXAZIDUM A07A X03 Gedeon Richter

COMPOSITION AND FORM OF RELEASE NIFUROXAZIDE RICHTER:

table p/o 100 mg, no. 24
Nifuroxazide 100 mg

Other ingredients: anhydrous colloidal silicon dioxide, potato starch, gelatin, talc, magnesium stearate, hypromellose, polyethylene glycol, yellow quinoline E 104, titanium dioxide (E171).

No. UA/9060/01/01 from 12/30/2009 to 12/30/2014

susp. d/oral. approx. 220 mg/5 ml vial. 90 ml, with measuring spoon, no. 1
Nifuroxazide 220 mg/5 ml

Other ingredients: carbomer 934, sucrose, sodium hydroxide, citric acid monohydrate, simethicone, methylparaben, banana essence, purified water.

No. UA/9060/02/01 from 08.11.2010 to 08.11.2015

PHARMACOLOGICAL PROPERTIES OF NIFUROXAZIDE RICHTER:

pharmacodynamics. Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran; active against most pathogens of intestinal infections (including mutant strains resistant to other antimicrobial agents). Shows a local antibacterial effect in the intestinal lumen against some types of gram-positive bacteria from the Staphylococcus family and some types of gram-negative bacteria from the Enterobacteriaceae family: Yersinia spp., Escherichia spp., Citrobacter spp., Enterobacter spp., Klebsiella spp., Salmonella spp.
Nifuroxazide does not have an antibacterial effect on bacteria of the species Proteus vulgaris, Proteus mirabilis and Pseudomonas aeruginosa.
It is assumed that the drug Nifuroxazide Richter inhibits the activity of dehydrogenases and disrupts protein synthesis in pathogenic bacteria. At moderate therapeutic doses it has bacteriostatic activity, and at higher doses it has a bactericidal effect. The effect appears from the first hours of administration. In therapeutic doses, it practically does not disturb the balance of the saprophytic bacterial flora of the large intestine; does not cause the development of resistant strains of pathogenic microorganisms and cross-resistance of bacteria to other antimicrobial agents, which allows, if necessary, in the case of generalized infections, to prescribe it in combination therapy with systemic antibacterial drugs. In case of intestinal infections of viral origin, it prevents the development of bacterial superinfection. The effectiveness of the drug does not depend on the pH in the intestinal lumen.
Pharmacokinetics. After oral administration, it is practically not absorbed into the gastrointestinal tract, creating a high concentration of the active substance in the intestine. Due to its pharmacokinetic properties, the drug has an exclusively enteral antiseptic effect, does not have systemic antibacterial activity, and does not cause general toxic effects; excreted unchanged from the body in feces.

INDICATIONS FOR NIFUROXAZIDE RICHTER:

spicy and and chronic diarrhea infectious genesis.

APPLICATION OF NIFUROXAZIDE RICHTER:

pills NIFUROXAZIDE RICHTER
Adults and children over 7 years of age are prescribed 2 tablets of Nifuroxazide Richter 4 times a day (every 6 hours). The drug is taken orally with a small amount of water, regardless of meals. The duration of treatment is no more than 7 days.
During the treatment of acute diarrhea, constant oral or intravenous replenishment of fluid deficiency in the body is mandatory, depending on the general condition patient.
Suspension NIFUROXAZIDE RICHTER
The drug Nifuroxazide Richter is taken orally. Before use, the bottle of suspension must be shaken thoroughly. For dosing, I use a double measuring spoon (included in the package) for 2.5 ml (smaller measuring spoon) or 5 ml (large measuring spoon). 1 smaller 2.5 ml scoop contains 110 mg of nifuroxazide; 1 large 5 ml scoop contains 220 mg of nifuroxazide.
Doses for children under 7 years of age: at the age of 1-6 months - 2.5 ml (1 smaller measuring spoon) 2-3 times a day; from 6 months to 2 years - 2.5 ml (1 smaller measuring spoon) 4 times a day; 2-7 years - 5 ml (1 large measuring spoon) 3 times a day.
Doses for children over 7 years of age and adults: children over 7 years of age and adults - 5 ml (1 large measuring spoon) 4 times a day; Children over 7 years old can use Nifuroxazide Richter film-coated tablets, 100 mg.
The drug Nifuroxazide Richter is recommended to be taken at regular intervals, regardless of meals. The course of treatment is 5-7 days. During the treatment of acute diarrhea, constant oral or intravenous replenishment of fluid deficiency in the body is necessary, depending on the general condition of the patient.

CONTRAINDICATIONS TO THE USE OF NIFUROXAZIDE RICHTER:

hypersensitivity to nifuroxazide and other nitrofuran derivatives or to any of excipients; Nifuroxazide Richter, tablets 100 mg, is used in children over 7 years of age, in children under 7 years of age the drug is used in the form of a suspension; for the suspension also - hereditary galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption; children's age up to 1 month.

SIDE EFFECTS OF NIFUROXAZIDE RICHTER:

Occasionally, organ and system disorders may occur.
From the side of blood and lymphatic system: in isolated cases - granulocytopenia.
From the gastrointestinal tract: individual cases of hypersensitivity to nifuroxazide are manifested by transient abdominal pain, nausea, vomiting and exacerbation of diarrhea. If such mild symptoms occur, there is no need to use special therapy or discontinue the use of nifuroxazide, as the symptoms quickly disappear. If the exacerbation is severe, you should stop taking nifuroxazide. In the future, the patient should not take nifuroxazide and other nitrofuran derivatives.
From the skin and subcutaneous tissue: reactions in the form of skin rash and itching rarely occur. In isolated cases - pustulosis (in an elderly patient), persistent papular urticaria (in the presence of a contact allergy to nifuroxazide).
Hypersensitivity reactions: in isolated cases, urticaria and shortness of breath were noted - conditions requiring discontinuation of the drug.

SPECIAL INSTRUCTIONS:

Before prescribing Nifuroxazide Richter in the form of an oral suspension in infants, it is necessary to exclude congenital deficiency of enzymes that break down sucrose.
Nifuroxazide is not recommended to be taken for more than 7 days. In case of ongoing diarrhea for more than 3 days from the start of treatment, in-depth diagnosis is necessary to determine the cause of the development of symptoms. Antibiotic therapy may be necessary.
The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia. In case of severe invasive diarrhea, an antibiotic should be prescribed, since nifuroxazide is not absorbed from the gastrointestinal tract.
If a hypersensitivity reaction occurs (shortness of breath, skin rash, itching), you should stop taking the drug.
During treatment, you should adhere to a certain diet: exclude juices, raw vegetables and fruits, spicy and difficult to digest foods.
The preservative methylparaben (E218) may be the cause allergic reaction slow type.
The drug contains sucrose, which must be taken into account when using it in patients with diabetes.
During treatment with nifuroxazide, you should not drink alcoholic beverages due to the possibility of developing disulfiram-like reactions, which are manifested by exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat, tinnitus, difficulty breathing, tachycardia, and a feeling of fear.
Use of the drug Nifuroxazide Richter during pregnancy and lactation
Pregnancy period. There are no clinical data regarding the use of nifuroxazide during pregnancy. Animal studies show neither direct nor indirect effects on the course of pregnancy, the development of the embryo or fetus, or the course of childbirth. The physician should carefully assess the benefit/risk ratio when prescribing nifuroxazide during pregnancy.
Breastfeeding period. It is known that nifuroxazide is not absorbed from the gastrointestinal tract. However, due to the lack of sufficient clinical data, caution should be exercised when prescribing nifuroxazide to women who are breastfeeding.
Children. Nifuroxazide Richter, 100 mg tablets, is used in children over 7 years of age. In children under 7 years of age, the drug is used in the form of a suspension. In the form of a suspension, the drug is not prescribed to children under 1 month of age.
The ability to influence the speed of reaction during control vehicles and working with other mechanisms. Nifuroxazide does not affect the reaction rate when driving vehicles or operating other mechanisms.

INTERACTIONS:

simultaneous (at the same time) administration of other oral medications (including sorbents) should be avoided due to the strong adsorption properties of nifuroxazide.
During treatment with nifuroxazide, you should not drink alcoholic beverages due to the possibility of developing a disulfiram-like reaction, which is manifested by exacerbation of diarrhea, vomiting, and abdominal pain.

OVERDOSE:

Symptoms of an overdose with Nifuroxazide Richter are unknown. In case of overdose, gastric lavage and symptomatic treatment are recommended.

STORAGE CONDITIONS:

at a temperature not exceeding 25 °C.

Nifuroxazide is one of the most indispensable medicines when intestinal problems arise. This drug has antibacterial properties, it pharmacological action is aimed at destroying harmful bacteria and viruses that enter the intestines.

It is especially good in cases of various intestinal infections. Helps to quickly normalize intestinal function, remove harmful toxins from the body and stabilize stool. The drug is produced by the pharmaceutical industry in many countries, such as Poland, Germany and Russia, and is available in different release forms.

Advantages of the drug

Why has Nifuroxazide become so popular? The main reason is its relative safety. The drug, as many people mistakenly believe, is an antibiotic, but it is not. The main effect is directly aimed at the bacterial flora of the intestine, but its chemical composition does not allow it to be classified as an antibiotic. The chemical affiliation of Nifuroxazide is a group of nitrofurans.

Positive properties are considered: the absence of a direct negative effect on the beneficial bacterial composition of the intestine, rapid absorption and, very importantly, it does not enter the common system blood supply and does not leave the intestinal tract with the blood flow. This pharmacological property allows it to be used by young children.

The mechanism of action of Nifuroxazide is not fully understood. It is believed that the antibacterial and antiseptic effect is carried out due to the inhibition of enzymatic activity and the synthesis of basic proteins in the structural cells of bacteria. There has not been a single case of the drug being addictive and leading to the emergence of a resistant bacterial strain.

When to use?

So, the main indications for the use of Nifuroxazide are:

• targeted treatment;
• the occurrence of dyspeptic intestinal disorder (diarrhea) in different forms manifestations;
• in acute and chronic stages of the disease (colitis and enterocolitis;
• as an auxiliary treatment for disturbances in the state of intestinal microflora (dysbacteriosis);
• as a prophylactic agent to prevent the occurrence of infections, as well as postoperative complications.

Despite the positive properties of Nifuroxazide, it should still be taken with caution. Like any medicine, it has contraindications: firstly, allergic manifestations to the use of the drug (individual intolerance), children under 3 months of age.

In rare cases, the drug causes side effects such as:

• nausea;
• dizziness;
• weakness;
• skin rashes accompanied by itching;
• Sometimes painful sensations in the abdominal area

Features of the drug use

Nifuroxazide is relatively freely allowed to be used by women in the category of pregnancy and nursing mothers. The medicine does not negatively affect the psychosomatic state, does not cause drowsiness and does not interfere with driving or human performance.

It is recommended to avoid eating raw vegetables and fruits during use. fatty foods, limit alcohol consumption (so as not to worsen the body’s condition, since alcohol can lead to exacerbation of dyspeptic disorders).
In any case, before using any medicine, you need to consult a specialist!

If you purchased Nifuroxazide Gedeon Richter, the instructions for use do not differ from the other form of release.
The dosage form differs between Nifuroxazide tablets and Nifuroxazide suspension.

Nifuroxazide instructions for use of the tablet:

Each box of any medicine contains instructions and the description of the tablets in it must correspond to the contents of the package!

Bright yellow tablets containing 100 mg of the drug. You should use the product as follows: swallow the tablet completely, without biting, and wash it down with a sufficient amount of boiled water. There is no fundamental difference in taking a tablet before or after a meal. Therefore, the patient decides this issue independently.

But it is very important to maintain intervals throughout the day when taking the medicine. They must be equal! Nifuroxazide tablets (dosage for adults): 2 tablets (200 mg) 4 times a day, every 6 hours. Please note that the tablets take much longer to digest than the suspension. As a rule, the course of treatment is about a week, but no one has canceled the individual characteristics of each organism, so the average is 5-7 days.

Nifuroxazide suspension: instructions for use

The suspension is available in a 125 ml bottle. External characteristics: light yellow color, aromatized and has a pleasant sweetish taste. Available in the form of a 4% solution. For convenient and correct dosage of the medicine, manufacturers have provided a measuring spoon in the package.

So, according to calculations, a volume of 2.5 ml leaves about 110 mg of the drug, and 5 ml - 220 mg. Prescribed internally. A special feature of Nifuroxazide in the form of a suspension is to take it with a sufficient amount of water. Do not forget that the suspension must be shaken before use. And another important point: the drug does not exist in syrup form, so do not confuse suspension and syrup!

The suspension is intended for both adults and younger patients. It is preferable to use it to treat intestinal infections in children. For adults, the dosage is: 1 measuring spoon (use a 5 ml spoon) 4 times a day.

Nifuroxazide is used quite widely in medical practice for children. The prescription of the drug is approved by most pediatricians, and it is also easily accepted by young patients. Relative safety for the beneficial microflora of the child's intestines, rapid absorption, convenient release form with a pleasant aromatic composition and flavoring additives are ideal for the treatment of infections in children.

Instructions for use in children (tablets): child over 6 years old. The dosage is exactly the same as for an adult, 2 tablets (200 mg) 4 times a day.

Instructions for use in children (suspension): the dosage is indicated by the doctor individually. To avoid side effects, it is imperative that the child has a congenital deficiency of a certain group of enzymes that affects the breakdown of carbohydrates (sucrose).

Dosage: child age 2-6 months – 1 measuring spoon (2.5 ml or 5 ml) 2 times a day. The time interval must be at least 12 hours.
Child age from 6 months – 1 measuring spoon (5 ml) 3 times a day. The time interval must be at least 8 hours.
For children over 6 years of age, the dosage is the same as for adults, i.e. 1 measuring spoon (5 ml) 4 times a day. The time interval must be at least 6 hours.

Drug interactions Nifuroxazide

Concomitant use with oral medications should be avoided to prevent increased absorption of the drug. The interaction with other drugs has not been fully studied (Nifuroxazide acts locally within the intestinal lumen, without passing through the blood to other organs and tissues of the body).

Currently existing Nifuroxazide analogues:

• Nifuroxazide-Richter (tablets and suspension);
• Ecofuril (100 mg capsules and 200 mg capsules);
• Lecor (200 mg capsules and suspension);
• Stopdiar (100 mg tablets);
• Enterofuril;
• Ersefuril.

Today in pharmacies you can see many medications for the treatment of intestinal infections in adults and children. Modern doctors most often prescribe Nifuroxazide to patients when indigestion occurs. The instructions included with the medicine contain detailed information about it. Before starting treatment, the patient must familiarize himself with its contents.

Description of the medicine

The drug is available in the form of a suspension (syrup) and tablets. Intended for oral use. Both dosage forms are equally effective in treating intestinal infections. Nifuroxazide tablets yellow color, they have a round, biconvex shape, covered with a smooth shell. Placed in blister packs. Each of them contains 24 tablets. Blisters are packed individually in cardboard boxes.

The drug "Nifuroxazide" (syrup) is available in the form of a yellow solution with a pleasant taste and banana aroma. Each bottle contains 90 ml of product. For ease of use, the suspension is sold together with a double-sided measuring spoon. The bottles are individually placed in cardboard packages.

Composition of tablets and syrup

Each tablet contains 100 mg of the active ingredient nifuroxazide. Besides him, this dosage form The drug includes magnesium stearate, starch, talc, gelatin, silicon dioxide. The tablet shell contains hydroxypropyl methylcellulose, talc, polyethylene glycol, titanium dioxide, and dye.

The suspension contains 4 g of the active ingredient nifuroxazide for every 100 ml of the drug. In addition, the syrup contains carboxypolymethylene, sodium hydroxide, citric acid monohydrate, methyl parahydroxybenzoate, water, sucrose, and banana flavor.

Indications for use, effect on the body

The drug "Nifuroxazide" is an antibacterial drug wide range actions. It is prescribed for acute and chronic diarrhea caused by gram-positive and gram-negative bacteria. Also, the drug "Nifuroxazide" is used to treat diarrhea caused by dysbacteriosis after taking antibiotics. Effective for eating disorders, autoimmune gastritis and diarrhea caused by appendicitis.

The drug "Nifuroxazide" (tablets and syrup in equal measure) is concentrated in the human digestive tract and acts within a short time after the start of treatment. It is not absorbed in the intestines and is excreted along with feces. The medicine does not have a systemic effect on the human body, does not affect the intestinal microflora and is not displayed on chemical composition blood.

Contraindications, features of administration

It should be remembered that only a doctor should prescribe the drug "Nifuroxazide". The instructions for the drug contain general information about it, therefore it is prohibited to prescribe it to yourself based on the manufacturer’s recommendations. Do not also forget that, like any other medicine, Nifuroxazide has contraindications and has a number of side effects on the body. Treatment with the drug, carried out under the supervision of a doctor, will avoid its negative effects on humans.

Contraindications to taking Nifuroxazide are:

• children under 2 months of age;
• prematurity;
• intolerance to individual components of the drug.

It is important to consider that Nifuroxazide (tablets) is not prescribed to children under 3 years of age. It is more convenient for young children to give the drug in syrup form.

If necessary, Nifuroxazide can be prescribed to pregnant and breastfeeding women, however, treatment of such patients should be carried out under the close supervision of a physician.

It is prohibited to combine the drug with drinking alcohol. Combining Nifuroxazide with alcohol can provoke the development of a disulfiram-like effect in the patient, manifested in the form of a deterioration in the general condition, increased diarrhea, nausea, vomiting, difficulty breathing, increased heart rate, and the onset of panic.

Side effect

When starting treatment, you need to become familiar with what side effect the drug "Nifuroxazide" can affect humans. The instructions list following symptoms that may arise during its use:

• allergic reaction in the form of itching and rash on the skin;
• dyspnea;
• discomfort in the digestive tract (nausea, vomiting, abdominal pain).

If the described side effects occur, the person should stop taking the medication and consult a doctor.

Drug doses, overdose

The drug "Nifuroxazide" for children in the form of a suspension is prescribed depending on their age and weight. For babies from 2 months to six months, it is prescribed 2.5-5 ml in the morning and evening (every 12 hours). Young patients aged 6 months to 6 years are given 5 ml of syrup 3 times a day. For children over 6 years of age and adults, the drug is prescribed 5 ml 4 times a day.

The drug "Nifuroxazide" in tablet form is prescribed to children from 3 to 6 years old 0.5 tablets four times a day. Children over 6 years old and adults need to take 1 tablet 4 times a day.

The doctor, based on the general condition of the patient, may increase or decrease the dosage of the drug recommended in the instructions. All portions of Nifuroxazide must be taken at equal intervals, regardless of meals. It is recommended to take the suspension and tablets with a sufficient amount of boiled water. It is not recommended to take the medicine for more than 7 days. If while using the drug the patient does not feel better or his condition worsens, he needs to consult a doctor as soon as possible.

To date, nothing is known about the symptoms of an overdose with Nifuroxazide. The instructions advise that if the dose of the medicine is significantly exceeded, the patient should undergo gastric lavage as soon as possible and show him to the doctor.

Adults should take into account that the drug "Nifuroxazide" in suspension has a pleasant sweet taste and is very popular with children. To prevent children from swallowing a large dose of medicine on their own, it must be hidden from them in inaccessible places.

Compatibility with other drugs, effect on driving

Not all medications can be combined with Nifuroxazide. Its use is contraindicated simultaneously with sorbents and medications containing alcohol. Interactions with other groups of drugs in this medical product was not identified.

The drug "Nifuroxazide" does not affect a person's attention and reaction speed, so it can be taken by drivers and people working near machines and other high-risk objects.

Shelf life, cost and analogues

The drug, regardless of the dosage form, should be kept at temperatures up to 25 degrees Celsius. The medicine "Nifuroxazide" (syrup) in a sealed state is stored for 3 years, the shelf life of the tablets also does not exceed 3 years. Please note that once opened, the bottle of suspension must be used within two weeks.

Not only the instructions are of interest to people to whom the doctor prescribed the drug "Nifuroxazide". The price of this medicine worries them no less. Today, the average cost of the drug in tablet form is 230 rubles. The drug "Nifuroxazide" in the form of a suspension will cost the buyer 280 rubles per bottle.

The drug has analogues, including Ersefuril, Enterofuril, Lekor, Nifurozid-Zdorovye. It is not recommended to independently replace the medication Nifuroxazide prescribed by a doctor with another medicine. The decision about the possibility of replacing the drug should be made by the doctor who prescribed it.

The drug "Nifuroxazide": reviews

The drug "Nifuroxazide" is not a cheap medicine, so many people, before buying it at the pharmacy, are interested in how effective it is in treating diarrhea. Because this drug Doctors prescribe it to patients quite often, and there are plenty of reviews about it. As evidenced by people who had to be treated with Nifuroxazide, it has a noticeable therapeutic effect already on the second or third day after starting treatment. It is well tolerated by patients of all ages and extremely rarely causes the side effects described in the instructions.

Medicine "Nifuroxazide" (suspension and tablets) - modern medical drug for the treatment of diarrhea. Its advantages are its effectiveness, a small list of contraindications, good tolerability and the possibility of use in both adults and children (with the exception of infants under 2 months). The disadvantages of the medicine include its high cost and the short shelf life of the syrup after opening the bottle.

In this article you can find instructions for use medicinal product Nifuroxazide. Reviews of site visitors - consumers of this medicine, as well as the opinions of specialist doctors on the use of Nifuroxazide in their practice are presented. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications were observed and side effects, perhaps not stated by the manufacturer in the annotation. Analogues of Nifuroxazide in the presence of existing structural analogues. Use for the treatment of diarrhea (diarrhea) in adults, children (including infants), as well as during pregnancy and breastfeeding. Interaction of the drug with alcohol.

Nifuroxazide- antidiarrheal drug. Nifuroxazide is a nitrofuran derivative that has an antibacterial effect against gastrointestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp.) and some gram-negative bacteria (Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli). Does not affect the composition of the normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.

Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains, and cross-resistance to other antibacterial drugs has not been observed.

The effectiveness of nifuroxazide does not depend either on the pH existing in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from the digestive tract and acts exclusively in the intestinal lumen.

Compound

Nifuroxazide + excipients.

Pharmacokinetics

Nifuroxazide is sparingly soluble. After oral administration, it is practically not absorbed from the gastrointestinal tract, creating a high concentration of the active substance in the intestine. Due to these pharmacokinetic properties, the drug has an exclusively enteral antiseptic effect, does not have systemic antibacterial activity, and does not cause general toxic effects; excreted from the body with feces.

The drug does not affect the clinical and biochemical parameters of blood tests.

Indications

• acute and chronic diarrhea caused by intestinal gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Haemophilus influenzae), as well as some gram-negative bacteria (Salmonella spp., Shigella spp., Klebsiella spp., Escherichia coli, Proteus spp., Enterobacter spp. ).

Release forms

Oral suspension 4% (sometimes mistakenly called syrup or solution).

Film-coated tablets 100 mg Richter.

Instructions for use and dosage regimen

Suspension

The drug is used orally. Before use, shake the bottle thoroughly until a homogeneous suspension is obtained.

Children from 2 months to 6 months: 1-2 scoops per 2.5 ml 2 times a day;

Children from 6 months to 6 years: 1 measuring spoon per 5 ml 3 times a day;

Children over 6 years old: 1 measuring spoon per 5 ml 4 times a day;

Adults: 1 scoop per 5 ml 4 times a day.

One 2.5 ml scoop contains 110 mg of nifuroxazide. One 5 ml scoop contains 220 mg of nifuroxazide.

Pills

Adults and children over 6 years of age are prescribed 2 tablets (200 mg) 4 times a day every 6 hours. The course of treatment is 6 days. Before use, you should consult your doctor.

Side effect

• abdominal pain;
• nausea;
• increased diarrhea;
• dyspnea;
• skin rashes;

Contraindications

• allergy to 5-nitrofuran derivatives;
• children up to 2 months;
• premature babies;
• hypersensitivity to any of the components of the drug.

Use during pregnancy and breastfeeding

There is no data regarding adverse effects on the fetus when using the drug during pregnancy. If necessary, with caution, the drug can be prescribed to pregnant and breastfeeding women.

Use in children

It can be used according to indications and in doses taking into account the patient’s age. Tablets are contraindicated in children under 6 years of age.

Special instructions

During treatment with Nifuroxazide, the use of alcoholic drinks, because alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction (exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat on the face and upper body, noise in the head, difficulty breathing, tachycardia, a feeling of fear).

The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia.

If there are symptoms of dehydration, it is necessary to carry out rehydration therapy in combination with treatment (for adults - about 2 liters of fluid per day).

During treatment, you should adhere to a certain diet: do not eat raw fruits and vegetables, juices, spicy and fatty foods.

Before prescribing the suspension to infants, it is necessary to exclude congenital deficiency of enzymes that break down sucrose.

Impact on the ability to drive vehicles and operate machinery

Nifuroxazide does not affect the ability to drive vehicles or operate machinery.

Drug interactions

During treatment with Nifuroxazide, simultaneous administration of oral medications should be avoided due to the strong adsorption properties of the drug.

Since nifuroxazide does not enter the circulatory system, interaction with systemic drugs unlikely and not yet known.

Analogues of the drug Nifuroxazide

Structural analogues of the active substance:

• Ecofuril;
• Enterofuril;
• Ersefuril.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.