Detailed instructions for use of the drug nystatin. Nystatin in urology: what is it for and how to take it? How to use Nystatin for thrush

We are surrounded by many pathogenic microorganisms, but they are not always able to cause development infectious diseases. With weakened immunity, negative effects environment and the influence of many other factors, favorable conditions are created for the growth and reproduction of pathogenic flora both on the skin and mucous membranes (especially in the mouth). The most common disease oral cavity and throat is candidiasis or so-called thrush. It is diagnosed in both young children and adults. Treatment for this pathology should begin as early as possible, because there is a high risk of developing a chronic form of candidiasis with the further spread of candida fungi throughout the body. Today, there are many different drugs that effectively fight fungus in the mouth, including Nystatin.

Symptoms

Obvious signs of candidiasis are a cheesy coating on the surface of the palate, the tongue of the inside of the cheeks. In some cases, film formation may occur on both the mucous membranes and lips. First, single foci of fungal infections develop in the mouth, which are localized in the tonsils, tongue or palate. Gradually, the existing fungal foci become more pronounced, the structure of the cheesy coating and its shade changes (from white to yellowish).

After removing the whitish film, ulcers open, the formation of small cracks is observed, and strong painful sensations.

Other signs of candidiasis:

• Hyperemia of the oral mucosa, swelling
• Increased temperature, increased excitability, tearfulness in young children
• Appetite disturbance
• Severe itching in areas where fungal infections are located.

If left untreated, the situation worsens significantly; the fungal infection spreads throughout the entire oral cavity, affecting the mucous membrane of the throat, gastrointestinal tract, and skin.

Causes of the disease

The development of candidiasis in the oral cavity can be caused by a number of reasons:

• Reduced immune defense
• Disturbance of the general microflora of mucous membranes and skin
• Lack of vitamins and minerals
• Infections from family members infected with candidiasis
• Presence of diseases that significantly reduce immunity
• Taking antibiotics radiation treatment, chemotherapy
• Incomplete course of antifungal therapy.

A series of laboratory tests will also help to identify the true cause of thrush.

How it works

A drug such as Nystatin is excellent in treating fungal infections, so it is often used for oral thrush. Under the influence of an antifungal substance, the growth and further spread of fungal spores is stopped. Due to the destructive effect on the cell membrane, the death of pathogenic flora occurs. When carrying out a course of therapy with Nystatin, it will be possible to get rid of thrush, as well as prevent the spread of candidiasis throughout the body.

It is worth noting that the drug is not active against pathogenic microorganisms that cause pathological conditions against the background of fungal infection with reduced immune defense.

The drug acts quite quickly, inhibition of the activity of Candida fungi is observed after the first use. The course of antifungal therapy usually lasts about 14 days. and depends on the characteristics of the disease, as well as the presence of active pathogenic effects.

Treatment: main options

Depending on how thrush manifests itself, local treatment, oral administration of antifungal drugs, or complex therapy are prescribed.

Usually drug therapy involves taking Nystatin for candidiasis of the mouth and throat. Additional measures include rinsing with herbal decoctions and baking soda solution.

If signs of candidiasis occur on the skin, Clotrimazole cream may be prescribed.

Features of the use of Nystatin

Tablets with antifungal action are prescribed to be taken regardless of meals. If you swallow the tablet, you will need to take it with a sufficient amount of liquid. The duration of the treatment course is 10-14 days.

In some cases, Nystatin can be prescribed in a different way: a tablet with a dosage of 500,000 units is placed behind the cheek and wait until it is completely dissolved. The medication should be taken strictly after eating and hygienic treatment of the oral cavity 3-5 times. per day.

Nystatin granules can be used for internal as well as external use for oral candidiasis in children. The preparation of a medicinal suspension is carried out by diluting the recommended amount of granules in a small volume of cold boiled water. The prepared suspension is given to the baby.

If the solution is prepared for external use, you will need to dissolve 2 g in 200 ml of chilled water. After this, you can carry out the procedure of rinsing your mouth.

It should be noted that the suspension has a slightly bitter taste, which children may not like.

Vitamin mixture with Nystatin

When it is necessary to treat infants, it is best to combine the use of Nystatin in Vit. B12. The vitamin component is added to the finished solution. This medicine has a beneficial effect on the child’s body, increasing its protective functions.

To prepare the mixture, you will need to dilute 1 tablet of Nystatin in water with a dosage of 250,000 units with 1 ml of vitamin. You need to use the medicine 3-6 times. per day, the exact treatment regimen is determined by the doctor.

A bandage or cotton pad is moistened in the resulting solution. After this, you need to wipe the areas of the mouth and throat affected by candidiasis, erasing the resulting plaque.

You will need to monitor the child’s condition; if any side symptoms occur, you should consult a doctor.

Contraindications

Treatment with a drug with antifungal properties is not recommended for:

• Excessive sensitivity to nystatin
• Congenital disorders of the gastrointestinal tract
• Severe liver ailments
• Pregnancy, GW.

Adverse reactions

Antifungal therapy may be accompanied by the development of a number of side effects:

• Allergic manifestations
• Nausea, epigastric pain, digestive disorders
• Temperature change
• Feverish state.

Prevention

To prevent the spread of fungal infection, you will need to follow the rules of personal hygiene, choose the right diet and pay special attention to oral care. It is recommended to refuse bad habits(smoking, drinking alcohol), if you have dentures, carry out their regular hygienic treatment. If you follow all these tips, the risk of candidiasis is significantly reduced.

If the patient is at risk (there are endocrine disorders, frequent infectious diseases, prolonged use of antibiotics), it is preferable to prescribe a prophylactic dosage of an antimycotic drug.

Take care of your health, prevention - effective way preventing the development of thrush.

Nystatin is a drug that is widely used to treat fungal infections that are caused by yeast or yeast-like fungi.

The drug can be used in all groups of patients (men, women (with restrictions during pregnancy, lactation) and children), however, currently its use is limited (gynecology, obstetrics, prevention of candidiasis in surgery after major operations or long-term antibiotic therapy in the treatment of internal diseases).

Compound

The main active ingredient in Nystatin is a polyene antibiotic, the main mechanism of action of which is binding to special molecules (complex sterol molecules) in membranes. As a result of this interaction, the protective function of the cell membrane is disrupted, an uncontrolled flow of ions into the cell occurs, which ultimately leads to its death.

In low concentrations it slows down, and in high concentrations it kills the fungal cell.

Main spectrum of action: yeast-like fungi (especially against Candida alb.), microorganisms of the Aspergillus group.

Release form

The product is available in 3 forms:

• Tablets - provide comprehensive treatment when the infection is in the intestines or localized in several places;
• Suppositories – for vaginal candidiasis;
• The ointment is suitable for treating skin and nails.

Approximate price of the drug

Manufacturer: OJSC Sintez (RF), RUE Belmedpreparaty (RB), OJSC Biosintez, etc.

Indications for use of Nystatin

Nystatin is prescribed:

• with skin fungus;
• damage to mucous membranes;
• intestines.

To prevent thrush, the medicine is prescribed during treatment with antibiotics, before operations on the intestines and genitals.

Contraindications

Nystatin contraindications are as follows:

• Intolerance (allergy) to the components of the drug (even in the past);
• Pregnancy;
• Breastfeeding (lactation period);
• Acute diseases of the gastrointestinal tract (cholecystitis, pancreatitis, peptic ulcer of the stomach and intestines, hepatitis).

Instructions for use of Nystatin

The treatment is not tied to food intake, the course lasts at least 10 days. Take twice a day with ½ glass of water.

Children are prescribed the product in the form of granules for internal use. A suspension is prepared from them by diluting with water. The granules are dissolved in water to create a rinse.

Vaginal ones are administered after hygienic procedures in the morning and at night in a lying position.

Anal ones are used after cleansing the intestines, also twice a day.

The ointment is applied to the external affected areas twice a day, often the ointment is combined with tablets.

Side effects

If the dosage is observed, it is well tolerated. Side effects rare:

• Decreased appetite, diarrhea, nausea, vomiting;
• fever, chills;
• skin allergy.

Special instructions

• Avoid alcohol: it affects carbohydrate metabolism and stimulates the proliferation of Candida fungi;
• Prescription together with Clotrimazole leads to a decrease in the concentration of the latter in the blood and a decrease in its therapeutic effect.
• Follow a diet - limit sweets and dairy products, increase the amount of fiber;
• If the skin becomes red or rashes, stop treatment;
• It is not recommended to use the medicine in the form of suppositories during menstruation;
• It is recommended to abstain from intimate life for the duration of treatment.

Treatment with Nystatin for thrush

This disease occurs more often in women. Reasons:

• Hypothermia;
• Chronic infections of the genitourinary system;
• Reduced immunity;
• pregnancy, etc.

Vaginal candidiasis often becomes chronic, especially when a sexual partner is infected. Therefore, if the patient is in a relationship, a man should undergo simultaneous therapy. And while taking the drug, sexual intercourse should be stopped.

If there is another infection, a complex drug with Nystatin is selected, consisting of: Polygynax, Terzhinan.

During pregnancy immune system is in a state of stress, so thrush occurs in every second woman. Usually Nystatin is not prescribed to pregnant women - only in rare cases, and only in the form of suppositories.

Men undergo treatment simultaneously with their sexual partner. They are prescribed tablets or ointment, often in combination.

For children, the drug is prescribed for mouth rinsing in the form of granules or tablets - a solution is prepared from them.

How to use Nystatin for thrush

The treatment regimen for acute thrush with Nystatin in women is as follows: vaginal suppositories are administered one suppository (0.5 million units) 2 times a day for at least 10 days (up to 14 days). For men, tablets of 0.25 million units - 0.5 million units are used 4 times a day for 14 days. The ointment is applied topically - applied to the affected areas 2 times a day for 10 days.

For chronic thrush, it is necessary to use the tablet form of Nystatin with local treatment ointment (for men) or suppositories (for women). The timing and regimen of treatment, doses of drugs, combination with other antifungal drugs are determined by the doctor.

Nystatin analogues

Nystatin analogues: Fungicidin, Terzhinan, Fluconazole, Moronal, Nystafungin, Natamycin, Pimafucin, etc.

Reviews about the drug Nystatin

According to reviews from patients who have been treated with Nystatin, the drug has established itself as a quick relief from symptoms - the effect appears on the 2-3rd day of treatment, symptoms disappear after 7 days of therapy. Side effects are rare and easily tolerated.

Among those noted by patients is a slight decrease in appetite, a feeling of heaviness in the stomach, especially when taken on an empty stomach. Nausea and other disorders of the gastrointestinal tract occur very rarely. To avoid them, you should take the medicine an hour after eating.

Oral administration of the tablet drug is more difficult to tolerate, while ointments and suppositories cause almost no side effects.

Additional information

• How to identify thrush in men
• Treatment of candidiasis
• Symptoms of candidiasis
• Treatment of thrush in children
• How to treat thrush during lactation

What are the causes of development and principles of treatment of oral candidiasis?

Oral thrush is a common fungal infection. It occurs in both adults and children. Usually a person is simply a carrier of the fungus. As a rule, in adults the disease is activated against the background of reduced immunity. Candidiasis fungus is often found in infants and older people.

Description of the disease

Oral candidiasis is a lesion of the mucous membrane on the cheeks, tongue, palate and lips, as seen in the photo. Thrush can begin as a dotted curdled scattering, which, if treatment is not started, merges into continuous lesions. Candidiasis often appears in the corners of the lips or on inside lips - and this can be seen in the photo.

The following reasons can provoke the disease:

• weak immunity;
• avitaminosis;
• pregnancy;
• taking antibiotics and hormonal drugs;
• chronic diseases(gastric or diabetes mellitus).

Thrush is highly contagious. It is easily transmitted from person to person. In general, a healthy immune system can overcome this virus. But, once in a weakened body, the fungus does not meet resistance and begins active reproduction.

Thrush can occur in the mouth due to trauma to the mucous membrane, for example, from an uncomfortable denture, hard food, or a too hard toothbrush. Appears on the affected areas white coating candidiasis, as in the photo, causing unpleasant itching or burning.

A favorable environment in which oral candidiasis can develop is created by low-grade body temperature or a violation of the alkaline balance in the mouth. For example, when a person overindulges in sweets, the first inflammations appear in the corners of the lips, shown in the photo, popularly called “jam”.

How is therapy carried out?

Treatment of oral candidiasis begins with diagnosis of the disease.

In order for the fight against fungus to be successful and thorough, chronic diseases of the body are taken into account: diabetes, stomach diseases, leukemia. To find out the general picture of candidiasis, the doctor listens to the patient, takes a scraping of plaque, and prescribes a blood test (general and to determine sugar levels). Based on the examination results, treatment is prescribed:

1. Local treatment. It is dealt with by periodontists or dentists. They check dentures, remove plaque, heal damage to the mucous membrane, and prescribe topical medications (ointments and rinses).
2. General treatment of candidiasis. It is prescribed both in cases of local damage (to prevent the infection from spreading beyond the oral mucosa) and when bacteria have already affected the entire body. The patient is referred to a mycologist or infectious disease specialist. These specialists select medications that have an effect aimed at systemically combating the fungus.

Treatment of oral candidiasis is carried out with antifungal drugs:

• imidazoles;
• polyene antibiotics.

Among the medications of the first group, preference is given to Nystatin and Levorin (in tablets), as well as Amphotericin (in tablets and intravenously). Among imidazoles, Econazole and Clotrimazole have proven themselves well. People prone to allergic reactions may be advised to use Suprastin, Pipolfen or other similar drugs, in parallel with potent antifungal drugs. The dosage and duration of the course are prescribed by the attending physician.

Fungal growth can also be stopped with other antimicrobial drugs:

• Nizoral,
• Diflucan,
• Fluconazole.

Fast-acting drugs are considered effective against candidiasis:

• candida vaccine,
• Methyluracil,
• Pentoxyl.

To strengthen the immune system, treatment is prescribed:

• vitamin complexes with elements of group B and PP;
• Calcium gluconate;
• Ferroplex or other preparations containing iron.

Local agents

Oral candidiasis destroys the mucous membrane, causing unpleasant itching and burning. Solutions of drugs can relieve irritating symptoms, as well as heal wounds in the mouth and stop the proliferation of fungus.

• sodium tetraborate (borax);
• boric acid;
• baking soda;
• Yoda.

Treatment with disinfectant and alkaline solutions reduces plaque, soothes inflammation, and accelerates healing. Rinsing can be done every 3 hours for two weeks if oral candidiasis is acute form. In case of a chronic condition of the disease, it is sufficient to treat the oral cavity after meals and before bedtime.

Other local remedies also have a beneficial effect:

1. Lubricating wounds with Yoddicerin.
2. Use of aniline dyes for the treatment of candidiasis in the oral cavity: brilliant green, fucorcin solution, methylene blue.
3. Local ointments: Nystatin, Levorin and others. They are usually prescribed if there is thrush on the lips, in the corners of the lips or stomatitis, as in the photo.

The listed drugs are not absorbed into the blood and do not cause allergic reactions. Dentures can be treated with alkaline solutions as a preventative measure.

Diet is necessary

Oral candidiasis cannot be treated with food. However, following a certain diet speeds up the healing process, prevents vitamin and mineral depletion of the body due to medication, restores the acid-base balance of the stomach, and therefore prevents the spread of fungus in the mucous membranes. The spread of fungus and inflammatory processes are provoked by the following products:

• yeast dough,
• sweets,
• smoking,
• fatty meat and fish,
• spices,
• alcoholic drinks.

It is not advisable to eat very dry and hard foods. It can injure the mucous membrane and provoke new candidiasis. Hot or too cold food and drink can be irritating.

Folk remedies

Oral candidiasis is popularly treated with home remedies that are designed to alleviate the patient’s suffering:

1. Decoctions. The most popular are decoctions of dill seeds, parsley roots, oak bark and St. John's wort. Two tablespoons of dry plant are poured into 1/2 liter of boiling water. The product is infused in a dark place and filtered. You can drink one tablespoon three times a day on an empty stomach. Treatment is carried out for two weeks. It is useful to rinse your mouth after eating (half a glass of infusion is diluted one to one with warm boiled water).
2. Rinse. In addition to decoctions, good remedy is the juice of cranberries, viburnum and carrots. They can not only be drunk, but also used to reduce plaque in the mouth.
3. Herbal tea. It is useful to brew calendula flowers and young blackcurrant leaves. The essential oils of these plants serve as a natural antibiotic and help heal lesions in the mouth.
4. Applications. Gauze swabs soaked in onion or garlic juice can be applied to the inflamed areas three times a day.

Treatment with thickened honey is considered the oldest folk remedy. One teaspoon of honey dissolves slowly in the mouth. It is more effective to do this after thoroughly rinsing the mouth or carefully removing plaque with a gauze swab.

Disease prevention

Oral candidiasis can be avoided or the risk of the disease can be minimized by following simple personal hygiene rules:

• rinse your mouth after eating;
• brush your teeth regularly (not with a hard brush);
• undergo a preventive examination at the dentist, clean plaque and tartar.

Attention should be paid to immunity:

• often walk in the fresh air;
• follow a diet;
• replenish the supply of vitamins and minerals in the body;
• do not abuse medications.

Children can become infected with candidiasis through adults, so each family member should have their own eating utensils. Thrush in children quickly affects the oral mucosa, forming large lesions, as in the photo. A young mother should pay special attention to hygiene so as not to pass the candidiasis fungus to her baby:

• do not lick your baby's pacifier;
• wash your breasts before feeding;
• take a shower daily;
• Do not take a bath with your baby.

Remember, even if oral thrush has never bothered you, any adult can be a carrier of it. Precautionary measures, hygiene and timely consultation with a dentist will reduce the risk of disease. And thanks modern drugs You can cure thrush completely.

http://youtu.be/J2Q7AvOrD5E

Antifungals: Cloves

Studies have shown that cloves can suppress the active growth of Candida fungi in both the mouth and intestines. As with many other spices, it was used for healing various diseases for centuries, including indigestion, diarrhea, hernia, and ringworm.

Cloves come from the evergreen clove tree, native to Indonesia, but today the spice can be found all over the world. The earliest use of cloves was seen in the Chinese Empire in 200 BC, when cloves were chewed to freshen breath before addressing the emperor.

How does Carnation work?

Cloves are a powerful antifungal and are often used to treat fungal infections. The use of clove oil as an antifungal agent is well supported by research. A 2001 study found that clove oil “quickly kills yeast cells.” A 2009 study found that "clove oil has significant antifungal effects against clinically relevant fungi."

The elements of clove oil are eugenol, eugenyl acetate, cariphyllene, of which eugenol is the active ingredient. Its antiseptic properties allow it to kill Candida fungi while it also boosts the immune system.

Uses of Cloves

Clove extract is the most effective remedy in the form of oil. Add 15 to 30 drops to warm water and take this tea 1-3 times a day. It is necessary to dilute the clove oil, as clove extract is actually quite powerful.

Clove oil also mixes quite well with other essential oils, e.g. essential oil basil, rosemary, rose, cinnamon and grapefruit. Can be mixed to make tea tastier!

Who Shouldn't Take Cloves

Regarding the use of clove oil during pregnancy and breastfeeding, you should consult your doctor. In addition, you should avoid clove oil if you have problems with the gastrointestinal tract. Some people may have allergic reaction on cloves so you need to start with a small dose.

Nystatin is an “old” antifungal antibiotic, representing a group of polyenes (so-called natural antibiotics) on pharmacy counters. The drug has a very narrow specialization, showing its antimycotic activity against only yeast-like fungi of the genus Candida. This happens as follows: nystatin interacts with sterols that are part of the cell membranes of fungi. As a result, the permeability of cell membranes is disrupted, which entails the release of the main components of the fungal cell into the wild. The action of nystatin is characterized as fungistatic, i.e. inhibiting the growth and reproduction of fungi. After removing the fungistatic agent, their growth has every chance of resuming.

Nystatin is available in four forms at once dosage forms: These are tablets, ointment, rectal and vaginal suppositories. When taking the drug orally, it is poorly absorbed from the gastrointestinal tract. Local application of nystatin avoids its absorption into the systemic circulation. The drug does not accumulate in the body and is excreted in feces. Indications for use of the drug will vary depending on the form of release. Thus, vaginal and rectal suppositories are used according to the site of administration, i.e. in the first case it will be vaginal candidiasis, and in the second - candidiasis of the lower intestine. Tablets are used for candidiasis of the skin and mucous membranes, as well as internal organs, ointment - only skin and mucous membranes. For prophylactic purposes, nystatin can be used in all forms of release. It should be noted that at present this drug, in the language of Internet memes, is “no longer a cake” and is gradually losing its position in relation to a number of diseases.

Thus, for decades, nystatin was practically the only drug for the treatment of oral candidiasis. However, previously collected information about 90% effectiveness this drug in modern realities they are not confirmed, and in clinical practice fluconazole has proven itself much more successful in treating this disease.

When internal organs are affected by candida, nystatin is prescribed orally, regardless of diet. Adults should take 500,000 units 4-8 times a day. For generalized candidiasis (when the fungal infection acquires impressive proportions), the daily dose of nystatin can reach up to 6,000,000 units. The doses of the drug used in pediatric practice depend on the age of the child: 250,000 units 3-4 times a day (from 1 to 3 years), 250,000-500,000 units 4 times a day (over 3 years). The duration of treatment is on average 10-14 days with the possibility of repeating the drug course after a week's "rest" from antimycotic therapy. The ointment should be applied to the areas of skin and mucous membranes affected by candida in a thin layer 2 times a day for 7-10 days. A combination of ointment and nystatin tablets is allowed. Before inserting vaginal suppositories into the vagina, the necessary hygienic procedures should be carried out. Dosage regimen: 1 suppository twice a day, morning and evening. The course of treatment is 10-14 days. The dosage frequency and dosage regimen for rectal suppositories is similar, only the route of administration into the body differs.

Pharmacology

Antifungal agent, antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to the release of the main components of the cell. Active against Candida albicans.

Pharmacokinetics

After oral administration, it is poorly absorbed from the gastrointestinal tract. It is excreted almost completely in the feces unchanged. Does not accumulate.

When applied externally and locally, it is not absorbed through the skin or mucous membranes.

Release form

10 pcs. - contour cell packaging (2) - cardboard packs.

Dosage

Orally for adults - 500,000-1,000,000 units 3-4 times/day, for children - 100,000 4 times/day. The average duration of treatment is 14 days.

Externally, intravaginally and rectally, apply 2 times a day in the morning and evening.

Interaction

With simultaneous use of nystatin with clotrimazole, the activity of the latter decreases.

Side effects

From the outside digestive system: nausea, vomiting, diarrhea.

Allergic reactions: skin rash, urticaria.

Local reactions: irritation.

There may be a risk of the spread of resistant forms of fungi, which requires discontinuation of nystatin.

Indications

Candidiasis of the skin, mucous membranes, oral cavity and pharynx, vagina and internal organs (gastrointestinal tract, lungs, kidneys). Prevention of fungal complications of antimicrobial therapy.

Contraindications

Liver failure, pancreatitis, gastric ulcer and duodenum, increased sensitivity to nystatin.

Features of application

Use during pregnancy and breastfeeding

Although nystatin is absorbed in small quantities, it is unknown whether it is excreted in breast milk, therefore, if use during lactation is necessary, the issue of stopping breastfeeding should be considered.

Use for liver dysfunction

Contraindicated in liver failure.

Special instructions

If local irritation or an allergic reaction develops, nystatin should be discontinued.

During menstruation, treatment should not be interrupted.

Fungal diseases must be treated at the first appearance of symptoms, otherwise damage to all organs and tissues of the body may occur.. One of the most popular and effective means against fungi - Nystatin. You should consider what kind of drug it is and for what diseases it is prescribed.

Description of the medicine

Despite the fact that Nystatin is intended for the treatment of fungal diseases, it is not considered an antifungal agent, but its pharmacological group– polyene antibiotics. This is a narrowly targeted medicine of natural origin, with high sensitivity to yeast and mold fungi.

Release forms:

When Nystatin molecules come into contact with fungi, they quickly penetrate the cell membrane. Having reached the required concentration, the drug forms pores in the membrane of the fungi, which leads to suppression of growth and slowdown of their activity. Fungal cells lose electrolytes, an excess supply of salts and liquid occurs, and ultimately the death of microorganisms occurs. Even a small amount of Nystatin in the body reduces the intensity of fungal proliferation, and at high concentrations it completely destroys them.

Nystatin almost does not react with other drugs, this is explained by its low absorption. When taken orally, the medicine is practically not absorbed into the gastrointestinal tract. But, if Nystatin is used simultaneously with other drugs, you should know how the drugs can affect each other (Table 1)

Table 1 - Use of Nystatin in combination with other drugs

Important! You must notify your doctor before taking any medicines if you are prescribed to take Nystatin.

This is especially true for internal reception. External agents with this active substance are practically not absorbed into the blood and cannot affect the action of other medications.

Indications and contraindications

The main indication for Nystatin is the treatment of diseases that develop as a result of active proliferation of fungi. Depending on the location of the infection, the doctor prescribes the most appropriate form of the drug.

It is important to know when choosing Nystatin why this drug is used in tablets:

Vaginal Nystatin suppositories are used for:

1. Therapy of candidiasis, vulvovaginitis and colpitis of fungal origin.
2. Prevention of infections caused by fungi with local antibacterial therapy.
3. Preventing candidiasis after surgery.

Dosage form for rectal use:

1. For fungal infections of the anus and colon.
2. Before and after proctological operations.
3. To prevent the proliferation of fungus in the presence of hemorrhoids, fissures, anal fistulas.

For Nystatin ointment, the indications are as follows:

1. When the skin is damaged by fungi.
2. Fungal infections of the genital organs.
3. Stomatitis and thrush in the oral cavity.
4. For extensive diaper rash to prevent fungal infection.
5. Treatment of fungus on the nail plates.

Many people believe that the drug Nystatin is used only in gynecology, but this is not so. It is widely used in urology: for the treatment of fungal prostatitis, cystitis and urethritis. In this case, both tablets are prescribed for oral administration and an ointment for application to the mucous membrane of the genital organs. For kidney inflammation of fungal origin, a course of Nystatin tablets is required. In addition, during long-term treatment of diseases of the urinary system with antibiotics, it is necessary to take this drug to prevent the development of fungal inflammation.

In surgery, this remedy is used to avoid the addition of fungal infections in the postoperative period. Nystatin is prescribed for elevated roseola and severe infections to prevent infection of weakened patients with fungi.

Important! Nystatin is strictly contraindicated when carrying a child at any stage and during lactation.

If it is not possible to replace the drug with another, then stop breastfeeding for the duration of treatment. Another 4 months before the planned conception of a child, it is necessary to stop taking Nystatin, especially for men, as it can affect the quality of sperm.

The drug is contraindicated for liver dysfunction, peptic ulcers of the stomach and intestines, pancreatitis. It is not prescribed if cases of allergic reactions to the components of the drug have been recorded.

Treatment regimens

Treatment with Nystatin cannot take place without a doctor's prescription. Only a specialist will be able to assess the patient’s condition, take tests to identify the causative agent of the infection and select the correct dose of the drug.

If treatment of diseases of the genital organs is carried out, then both partners should use the drug, even if signs of inflammation are present in only one of them.

Treatment of genital candidiasis:

For skin diseases that occur without damage to internal organs, it is enough to lubricate the affected areas twice a day. The course of therapy is at least 10 days.

The use of tablets is indicated for internal lesions. How to take Nystatin:

1. Adults one tablet (250 thousand units) up to eight times a day.
2. Adults one tablet (500 thousand units) three times a day.
3. Children from 12 months to 3 years of age are prescribed one tablet (250 thousand units) three times a day.
4. From 3 years of age the dosage increases: one tablet (250 thousand units) four times a day.

For severe lesions, the dose can be doubled, but only as directed by a doctor. The duration of therapy is 7-10 days, the course is repeated if necessary. For children under one year old, only a doctor can select the dosage based on the child’s condition, his weight and the presence of concomitant diseases.

For cystitis, prostatitis and urethritis, nystatin is taken not only orally, but also ointment is applied to the mucous membranes of the genital organs and the opening of the urethra to improve the effect of treatment and prevent re-infection.

For diseases of the oral mucosa, use ointment or wipe the affected areas with a solution of water and Nystatin tablets. Adults can hold the tablet in their mouth until it dissolves.

Nystatin is a low-toxic drug, therefore side effects do not occur often. What the patient may feel:

If side effects occur when taking Nystatin, you should consult a doctor to choose another antifungal agent with a different active ingredient in the composition. However, if you follow the doctor’s recommendations, the drug in most cases is able to completely neutralize the effect of pathological microorganisms.

Pathogenic and opportunistic fungi cause diseases that are widespread today. To treat such diseases (mycoses), various antifungal drugs are produced, which are used in accordance with the sensitivity of certain pathogens of fungal infections to them.

How do nystatin tablets work?

Nystatin tablets, when taken orally, act mainly locally, on the mucous membrane of the gastrointestinal tract, after which most of the nystatin is excreted in the feces. A small part of nystatin taken orally is absorbed into the blood, therefore, to treat fungal infections of other internal organs, such as the respiratory system, it must be taken in very large doses. Today this is considered inappropriate, since there are other, more effective antifungal drugs.

Nystatin acts mainly against fungi of the genus Candida, so it is used to treat candidiasis (candidomycosis) - fungal infections caused by this type of fungus. Nystatin has an affinity for some substances that are part of the cytoplasmic membranes of cells of fungi of the genus Candida; it enters the membranes and disrupts their permeability, which contributes to the suspension of vital activity and destruction of fungi. Sometimes, during the treatment of candidiasis, resistance (immunity) of the pathogens of this fungal infection to nystatin develops, this dangerous complication, since fungi that are insensitive to the drug begin to quickly multiply and spread throughout the body. In this case, immediate replacement of nystatitis with another antifungal agent is required.

How does candidiasis of the digestive organs manifest?

Candidiasis can develop in any part of the gastrointestinal tract, from the mouth and pharynx to the rectum. Often the entire gastrointestinal tract.

Candidiasis of the oral mucosa (thrush or candidal stomatitisStomatitis - to keep your breath fresh oral cavity) is manifested by redness and swelling of the mucous membranes, on which white cheesy deposits appear. The same plaques can occur on the tongue (candidal glossitis), as well as on the walls of the pharynx (candidal pharyngitis) and on the palatine tonsils. When the pharynx is affected, it becomes difficult for the patient to swallow. Most often, candidal stomatitis occurs in infants and elderly people who have decreased immunity.

With candidiasis of the esophagus and stomach, heartburn, nausea, and loss of appetite appear. Vomiting often develops, and white crumbs or even films can be seen in the vomit, depending on the degree of damage to the mucous membranes by the fungus.

Intestinal candidiasis is manifested by flatulence - bloating of the intestines due to increased gas formation. This happens because if there are a large number of fungi in the intestines, the process of food digestion is disrupted. Debilitating, long-lasting diarrhea also occurs, as a result of which the patient is deprived of part of the substances necessary for metabolism. Metabolism: the basis of the life activity of all living things. food ingredients. The stool usually contains mucus, and there may also be streaks of blood.

Nystatin tablets in the treatment of candidiasis of the digestive system

Since nystatinNystatin will help with candidiasis It acts mainly locally, on the mucous membrane of the gastrointestinal tract; it is often used for candidiasis of the digestive organs. If there is a suspicion of candidiasis of the bronchopulmonary or urinary systems, then other antifungal drugs are used.

For candidal stomatitis, glossitis and pharyngitis, nystatitin tablets can be sucked - this will be more effective than simply swallowing. You can dissolve a tablet (500,000 units) in this way six to eight times a day. For young children, the tablets are ground and the powder is sprinkled on the mucous membranes several times a day, using one to one and a half tablets of 250,000 units per day.

For candidiasis of the esophagus, stomach and intestines, nystatin is prescribed orally to adults, one or two tablets (500,000 units per tablet) four times a day for at least two weeks. Children are prescribed a lower dose depending on age.

Side effects

Nystatin tablets, when taken orally, can have a negative effect on the liver, so they should not be used for liver diseases that impair its function. Nystatin should not be used for inflammatory processes in the pancreasDiabetes and the pancreas - things you need to know (pancreatitis), as well as with peptic ulcer stomach and duodenum. And, of course, nystatin tablets are not prescribed if you are hypersensitive to this drug.

Nystatin is non-toxic and well tolerated when taken orally. Sometimes when taking it, phenomena such as decreased appetite, nausea, vomiting and diarrhea may occur. Allergic reactions are also possible.

Nystatitin tablets are still used today to treat candidiasis.

Galina Romanenko

Damage to the mucous membrane in the mouth, which leads to the formation of ulcers and blisters, indicates the presence of a disease such as stomatitis. Reason for inflammatory process can become fungi, viruses and bacteria that have penetrated both from inside the body and from outside.

Nystatin - medicinal product, which is prescribed exclusively by a qualified specialist for the treatment of fungal stomatitis. The causative agent in this case is fungi belonging to the genus Candida.

Nystatin is available in the form of tablets, ointments or drops; there are also suspensions on sale that are intended for rinsing. Tablets, as a rule, are packaged in packs of ten or twenty pieces, ointment from fifteen to twenty grams in a tube, drops of five milliliters, suspension is dosed in two hundred thousand units.

About the medication in the context of stomatitis treatment

Fungal stomatitis (candidiasis or thrush) is observed in both adults and children, as well as in newborns. Even small doses of Nystatin can slow down further development thrush, and systematic therapy should completely destroy the fungus.

To treat stomatitis, nystatin ointment is actively used, which destroys the permeability of fungal cells, so the main bacterial components are destroyed.

Due to the fact that Nystatin neutralizes fungal infections, it is recommended only for candidal stomatitis of the oral cavity.

The molecule of the active component of the drug consists of double bonds, which causes the penetration of the active element into the cells of the fungus. Then the electrolytic process intensifies, causing the fungal cell to be destroyed. There is virtually no resistance or resistance.

In addition to the fact that the medication is used in the treatment of candidal stomatitis, it is also effective as a preventive measure for this disease.

For preventive purposes, Nystatin is effective in preventing the development of

candidiasis

in cases where fairly long-term treatment with drugs such as Penicillin, tetracycline antibiotics, Neomycin, Levomycetin and others is expected.

Instructions for use - doses and intended course of treatment

When treating candidal stomatitis in adults, Nystatin tablets are used, which need to be dissolved; ointment is used less often. It is recommended to take the tablets after meals, maximum four times a day.

The ointment is applied to the damaged area twice a day, the course of treatment lasts until the pathological plaque in the oral cavity completely disappears.

Often, treatment of stomatitis involves taking other medications. When taken simultaneously with Nystatin and Tetracycline, an antimicrobial effect is achieved. When the drug is combined with bactericidal antibiotics, the effect of the latter has been proven to decrease.

Nystatin also reduces the effect of indirect anticoagulants, Clotrimazole and oral contraceptives.

Therapy for young patients

The most convenient solution for children is an aqueous solution, for which you need to dissolve a Nystatin tablet (two hundred and fifty thousand units) in a glass of water.

Older children can be offered tablets for oral administration. In this case, only a doctor can calculate the exact dosage based on how the body reacts to the drug in question.

The full dose, taken after meals and washed down with plenty of water, is divided into several doses. Treatment of stomatitis in children takes a maximum of two weeks. In addition to the pills, children are also prescribed a five percent ointment, which is applied three times throughout the day using cotton swabs.

Until the age of fourteen, a child can be given tablets to dissolve. When taking Nystatin orally, it is necessary to take into account the frequency, duration of the course, dosage and characteristics of the child’s body.

Local treatment is also possible with the help of an ointment, which should cover all foci of infection. Penetrating into the gastrointestinal tract, the ointment is not absorbed; accordingly, it is excreted in its original state.

Treatment of infants

Stomatitis in infancy is treated with ready-made aqueous solutions Nystatin, drops, or mixed with vitamin B12 if local treatment is necessary. In this option, one tablet is ground into powder and combined with vitamin B12.

After this, the finger is moistened with the prepared homogeneous mixture, which must first be wrapped in a sterile bandage. The plaque area in the mouth is then treated.

The procedure for treating the baby’s oral cavity should be carried out four to five times a day after meals. Upon completion, you must wait thirty minutes without drinking or water.

Contraindications and special instructions for use

Immediately before using the drug, it is strongly recommended that you read the attached instructions, paying special attention to the indicated contraindications. These include the following:

presence of pregnancy; diagnosing gastric ulcers; existing allergic reaction to the components of the drug; manifestation of sensitivity to the drug; pancreatitis; impaired activity of the kidneys and liver; lactation.

There is a possibility of developing such side effects as nausea, pain, itching, changes in stool, vomiting, and swelling in the oral cavity may also occur. The manifestation of one or more of these symptoms is a compelling reason to visit a qualified specialist.

Proper storage of the medication is also important, which must be kept in a dry and dark place where the temperature is at least six degrees.

Experienced word

The use of Nystatin for the treatment of candidal stomatitis is quite popular, as evidenced by numerous positive reviews, available online.

Nystatin ointment is always at hand, since I have two children. It is quite easy to apply, especially since very little is required. The main thing is to avoid overdose and follow the instructions.

Natalya, 30 years old

The medication is well tolerated and costs a penny, especially since it really helps with stomatitis, tested from my own experience.

Svetlana, 39 years old

For as long as I can remember, stomatitis has always bothered me. I tried the most advertised and expensive medications, but later I learned about Nystatin and was simply amazed at the speed of its action and, importantly, its low cost.

Egor, 34 years old

Summing up

The main benefits of Nystatin are:

low cost; it is possible to treat wounds even in newborns; ease of use; exclusion of cases of absorption into the systemic circulation.

But it should be remembered that with an overdose of the drug, the body reacts with burning and itching, and severe swelling can also be observed.

Thus, treatment of stomatitis with Nystatin actually stops the development of the disease, and the active components of the drug destroy pathogenic fungi in the oral cavity.

Question:“By all indications, there is a fungal infection of the upper respiratory tract after using antibiotics for bronchitis (I had my sputum tested). The instructions for use of nystatin indicate only oral administration without chewing. Although several years ago the doctor recommended that I dissolve them. Question - this is acceptable (although very disgusting :-))) and more effective for the bronchi than just swallowing. Sincerely"

Good afternoon.

Nystatin

has low absorption in the intestines and is used as a means of local action. If the candidiasis lesion is localized in the oral cavity, the tablets must be resorbed. If necessary, influence digestive tract The tablets are swallowed whole, do not chew. The effectiveness of the drug for fungal infections of the upper respiratory tract is questionable due to the local effect of nystatin. Otherwise it would have to be nystatin aerosol or, most likely, another antifungal drug. Surely the instructions for the drug do not indicate the use of nystatin for respiratory candidiasis. Don't study

self-medication

And consult a doctor. It is possible that you have residual effects from bronchitis.