How to take Cardiomagnyl. Benefits and harms of cardiomagnyl, features of the drug, indications and contraindications

Update: October 2018

Cardiomagnyl is an anti-inflammatory drug (non-steroidal), an antiplatelet agent, which is used to prevent the development of thrombosis and acute heart failure in patients with certain cardiovascular diseases or risk factors that increase the complications of these diseases.

The anti-inflammatory effects of the drug are associated with irreversible inhibition of cyclooxygenase-1 by acetylation and blocking the formation of thromboxane A2. All this leads to the suppression of aggregation of blood platelet cells, and therefore the prevention of thrombosis.

Pharmgroup: NSAIDs, antiplatelet agents.

Composition, physical and chemical properties, price

Available in the form of white oral tablets, in a specific heart-shaped form. Covered with a film shell.

Composition of cardiomagnyl per 1 tablet:

• Main substance: acetylsalicylic acid - 75 mg, magnesium hydroxide - 15.2 mg. The “forte” form of the drug contains a 2-fold higher dose of active ingredients: acetylsalicylic acid – 150 mg, magnesium hydroxide – 30.39 mg.
• Excipients: magnesium stearate, corn and potato starch, microcrystalline cellulose.
• Shell composition: hypromellose, propylene glycol, talc.

Available in brown glass bottles of 30 and 100 tablets. Price:

• 75 mg No. 100 – 200-250 rub.,
• 150 mg No. 100 – 300-400 rub.

Pharmacological action

Cardiomagnyl is characterized by a pronounced antiplatelet effect. The well-known acetylsalicylic acid, which is part of the drug, in large doses (500 mg - the average therapeutic dose for an adult) has a pronounced anti-inflammatory effect, eliminates pain, inflammation and elevated temperature. In small doses, it prevents platelet aggregation, the formation of blood clots, and also has a mild anti-inflammatory effect:

• irreversibly inhibits cyclooxygenase-1, which is involved in the formation of prostaglandins that trigger an inflammatory response in the body;
• inhibits the synthesis of thromboxane A2 in platelets, thus preventing their aggregation (sticking together).

To achieve these effects, the drug should be used for a long time, in recommended doses.

Magnesium hydroxide has a protective effect on the gastrointestinal mucosa and protects it from the action of acetyl salicylic acid.

Pharmacokinetics

Acetylsalicylic acid (ASA) is completely absorbed from the gastrointestinal tract. The hydrolysis reaction to salicylic acid is carried out using hepatic esterases in the liver, as well as in the blood plasma and intestines. The half-life of ASA is about 15 minutes, and salicylic acid is about 3 hours. Additional intake of ASA (above 3 g) can lengthen the half-life of the metabolite (salicylic acid) due to the absolute saturation of enzyme systems.

The bioavailability of salicylic acid is 80-100%, i.e. is high. The bioavailability of ASA varies at 70%, but may be altered by presystemic hydrolysis in the gastric wall, as well as in the intestine and liver. It is very important that magnesium hydroxide does not in any way affect the bioavailability of ASA.

Indications

Indications for the use of cardiomagnyl are as follows:

• Primary prevention of heart and vascular diseases - thrombosis and acute heart failure against the background of risk factors: diabetes mellitus, arterial hypertension, hyperlipidemia, obesity, smoking, old age;
• Prevention of recurrent myocardial infarction and thrombosis blood vessels;
• Prevention of thromboembolism after vascular operations: coronary artery bypass grafting, coronary angioplasty (transluminal);
• Angina pectoris is unstable.

Contraindications

The instructions for use of cardiomagnyl indicate the following restrictions on use:

• Hemorrhage in brain tissue;
• Tendency to bleeding due to vitamin K deficiency, hemorrhagic diathesis, thrombocytopenia;
• Erosive and ulcerative pathologies of the gastrointestinal tract in the acute phase;
• Gastrointestinal bleeding;
• Bronchial asthma induced by treatment with salicylates and NSAIDs;
• Severe kidney dysfunction (KD)<10 мл/мин);
• Deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• Concomitant treatment with methotrexate at a dose of more than 5 mg per week;
• 1st, 3rd trimesters of pregnancy;
• Lactation;
• Children under 18 years of age;
• Hypersensitivity to ASA, additional substances in the drug and other NSAIDs.

Contraindications for cardiomagnyl should never be ignored - negative reactions from the body are serious and even life-threatening.

Special instructions

The drug is prescribed with caution and under the supervision of a doctor in the following cases:

• hyperuricemia;
• history of ulcerative lesions of the gastrointestinal tract or bleeding from the gastrointestinal tract;
• gout;
• renal or liver failure;
• bronchial asthma;
• hay fever;
• allergic conditions;
• nasal polyposis;
• 2nd trimester of pregnancy.

It should be remembered that acetylsalicylic acid can cause bronchospasm, attacks of bronchial asthma and other hypersensitivity reactions.

Also, the active substance can cause bleeding during and after operations. Therefore, before surgery, the attending physician should assess the risk of bleeding compared with the risk of ischemic complications in patients being treated with cardiomagnyl, and based on this, decide whether to discontinue the drug or continue taking it. It should also be remembered that acetylsalicylic acid in combination with thrombolytics, anticoagulants and antiplatelet drugs is also characterized by an increased risk of bleeding.

Treatment with the drug may provoke the development of gout in patients with a predisposition to the disease (with reduced excretion of uric acid).

In combination with methotrexate (even in low doses), there is an increased incidence of side effects from the hematopoietic system.

High doses of ASA have a hypoglycemic effect, so patients with diabetes mellitus treated with hypoglycemic drugs internally and receiving insulin should be careful during treatment.

Unauthorized excess of the drug dose directly increases the risk of bleeding from the gastrointestinal tract.

During long-term treatment with the drug, caution should be exercised in elderly patients - the risk of developing gastrointestinal bleeding in this age group is always higher.

During treatment, you should not drink alcohol, as this also increases the risk of damage to the gastrointestinal mucosa, and if bleeding develops, its duration increases.

Dosage

The tablets must be swallowed whole with water. If swallowing is difficult, you can break the tablet in half or crush it into powder.

• Primary prevention of CVS: thrombosis, acute heart failure against the background of the risk factors listed above, on the first day, a “Forte” tablet of 150 mg (or 2 of 72 mg) is prescribed per single dose, and then switched to a dose of 75 mg once a day (regular cardiomagnyl tablet );
• Prevention of recurrent myocardial infarction and thrombosis: 1 tablet 75 or 150 mg once a day. The dose is selected individually;
• Prevention of thromboembolism after vascular surgery: 1 tablet 75 or 150 mg once a day. The dose is selected individually;
• Unstable angina: also 1 tablet 75 or 150 mg once a day. The dose is selected individually.

Overdose

An overdose of the drug can be moderate to severe.

The clinical picture of a moderate overdose: vomiting, nausea, hearing impairment, tinnitus, confusion and dizziness. Treatment includes gastric lavage, taking an adequate dose of activated carbon and other drugs for symptomatic therapy, depending on the clinic.

The clinical picture of a moderate overdose: hyperventilation, fever, respiratory alkalosis, ketoacidosis, coma, respiratory and cardiovascular failure, severe hypoglycemia. Treatment necessarily involves immediate hospitalization for emergency treatment in the intensive care unit and includes: administration of alkaline solutions, gastric lavage, forced and alkaline diuresis (so that the blood pH becomes 7.5-8), hemodialysis and the use of other drugs for symptomatic therapy.

Side effects

Side effects of cardiomagnyl can be observed in different systems:

• Allergic phenomena: urticaria often occurs, a little less often - Quincke's edema, and anaphylactic-type reactions up to shock can rarely develop.
• From the gastrointestinal tract: very often patients note heartburn, nausea and vomiting often occur. Pain in the abdomen is sometimes observed, ulcers may develop on the mucous membrane of the stomach and duodenum, as well as bleeding from the gastrointestinal tract. Quite rarely, but still there are cases of perforation of a stomach or duodenal ulcer, and increased liver enzymes. In the rarest cases, stomatitis, erosive changes in the upper gastrointestinal tract, esophagitis, colitis, strictures, and irritable bowel syndrome are possible.
• From the respiratory system bronchospasm often develops.
• From the hematopoietic organs: increased bleeding is observed very often; rarely - anemia. Hypoprothrombinemia, neutropenia, thrombocytopenia, aplastic anemia, eosinophilia, and agranulocytosis develop very rarely.
• From the side of the central nervous system: dizziness, drowsiness are observed in some cases. Patients often report headaches and sleep disturbances in the form of insomnia. Rarely there is tinnitus and very rarely intracerebral hemorrhage.

Drug interactions

Cardiomagnyl enhances the effect of the following drugs when treated simultaneously:

• methotrexate - by reducing renal clearance and displacing it from protein binding;
• indirect anticoagulants and heparin- by changing platelet function and displacing anticoagulants from binding with proteins;
• thrombolytic and antiplatelet drugs, for example, ticlopidine;
• hypoglycemic agents oral and insulin by a similar mechanism;
• digoxin, causing a decrease in its renal excretion;
• valproic acid, displacing it from its connection with proteins.

In combination with ibuprofen, the cardioprotective effects of acetylsalicylic acid are reduced.

When taking cardiomagnyl with drugs containing ethanol, the effect of both drugs is enhanced.

The effect of uricosuric drugs while taking cardiomagnyl is reduced due to tubular competitive elimination of uric acid.

By enhancing the elimination of salicylate drugs, systemic corticosteroids weaken their effects.

When treated simultaneously with antacids and cholestyramine, the absorption of acetylsalicylic acid is reduced.

Thromboass or cardiomagnyl?

Which is better: thromboass or cardiomagnyl? This question is asked by many patients. Let's try to figure it out.

One of the most significant advantages for the patient is the lower price of the drug Thromboass: a package of 100 tablets at a dosage of 100 mg will cost 120-180 rubles. However, cardiomagnyl tablets also belong to the group of affordable medications, and given the fact that you need to take it once a day, they will not hit your wallet hard.

Medicines are interchangeable: they have almost the same indications, contraindications and side effects. The active ingredient is the same - acetylsalicylic acid, only in different dosages. Thus, cardiomagnyl contains 100 or 150 mg of ASA, and thromboass - 50 or 100 mg. It has been proven that small doses of ASA have an antiplatelet effect, so in this regard both drugs will be effective.

The drug cardiomagnyl contains a second active component - magnesium hydroxide, which protects the gastrointestinal mucosa from the negative effects of ASA. Thromboass does not contain such a component, but has a special shell that does not dissolve in the stomach under the influence of hydrochloric acid and is absorbed already in the duodenum. However, not all patients, for health reasons or other reasons, are able to swallow the tablet whole, and when chewed, the protective properties of the coating are already lost. In addition, even if the tablet is swallowed whole, ASA does not act only on the gastric mucosa, while it is already absorbed in the duodenum, while many patients have combined ulcerative lesions of both the stomach and duodenum.

Cardiomagnyl has an antiplatelet effect and is a non-steroidal anti-inflammatory drug. The anti-inflammatory effect is associated with irreversible inhibition of cyclooxygenase-1 due to the acetylation reaction. Thromboxane A2 under the influence of acetylsalicylic acid (ASA) is reduced as a result of selective inhibition of its synthesis. There are probably other mechanisms for reducing platelet aggregation under the influence of ASA.

Magnesium hydroxide has a protective effect on the gastric mucosa, which is important when taking ASA.

ASA is completely absorbed when taken orally from the gastrointestinal tract. Hydrolysis to salicylic acid occurs with the participation of esterases in the liver, intestines and blood plasma. The half-life of ASA is 15 minutes, salicylic acid is 3 hours. Additional intake of ASA (more than 3 g) may prolong the half-life of salicylic acid due to complete saturation of enzyme systems. The bioavailability of the ASA metabolite, salicylic acid, ranges from 80 to 100%. The bioavailability of ASA is approximately 70%, but this value is very variable due to presystemic hydrolysis in the wall of the stomach, intestines and liver tissue. Magnesium hydroxide cardiomagnile does not affect the bioavailability of ASA.

Indications for use

Preventive therapy for increased platelet aggregation in: thrombosis and embolism, coronary heart disease, myocardial infarction, ischemic strokes and cerebrovascular accidents, migraine.

Used for the prevention of thrombosis in cardiovascular surgery (in the postoperative period after coronary angioplasty, coronary artery bypass grafting).

Directions for use

1 tablet cardiomagnila-forte or 2 tablets cardiomagnetic(150 g of ASA) on the first day of treatment, then 75 mg (1 tablet of cardiomagnyl) 1 time per day. Take the tablet with a small amount of water. If necessary, the tablets are chewed or crushed. It is recommended to consume after meals. The duration of treatment is determined by the doctor individually depending on the clinic, indications and severity of the disease.

Side effects

Allergic reactions, bronchospasm, hemorrhagic stroke, bleeding from the gastrointestinal tract. Heartburn, dyspeptic disorders, irritable bowel syndrome, ulcers of the gastrointestinal mucosa, and perforation of an existing gastrointestinal ulcer may occur. A clinical blood test reveals eosinophilia, decreased platelet count, aplastic anemia, neutropenia, and agranulocytosis. The coagulogram shows hypoprothrombinemia. Rarely, headache, tinnitus, drowsiness, and dizziness are observed.

Contraindications

Tendency to bleeding or a recent episode of bleeding (hemorrhagic diathesis, hemorrhagic stroke, hypothrombinemia, gastrointestinal bleeding, hemophilia);
bronchial asthma in response to the administration of ASA;
allergy to the components of the drug (especially ASA);
deficiency of glucose-6-phosphate dehydrogenase;
renal failure;
taking methotrexate at a dose of more than 15 mg/week;
age up to 18 years.

Pregnancy

Contraindicated for use cardiomagnetic in 1 (anomalies of fetal development) and 3 (increased bleeding during childbirth, intraventricular hemorrhages in the fetus, premature closure of the oval duct of the fetus, anomalies labor activity) trimesters of pregnancy, as well as lactating women. In the 2nd trimester it is prescribed with caution.

Interaction with other drugs

The combined use of a high dose of cardiomagnyl and oral anticoagulants potentiates the effect of the latter. Cardiomagnyl potentiates the effects of fibrinolytics and antiplatelet agents. Diuretics (spironolactone) and antihypertensives reduce their effect when taking cardiomagnyl. Enhances the effects of chlorpropamide and methotrexate. The absorption of cardiomagnyl is significantly reduced when using antacids and sorbents.

Overdose

In case of overdose cardiomagnetic Tachypnea develops, bleeding time prolongs, nausea, anxiety, tinnitus, sweating, and decreased hearing acuity occur. Vomit contains streaks of blood. A dangerous dosage is considered to be 150 mg/kg. In severe cases, ketoacidosis, cardiac arrhythmias, hypoglycemia, acute cardiovascular failure, hyperventilation, acute respiratory failure, and coma develop.

If signs of overdose are detected, the patient is hospitalized, the stomach is washed, sorption enteral drugs are prescribed, and, if necessary, alkaline diuresis is provided. In the future, symptomatic therapy is necessary.

Release form

Cardiomagnyl And cardiomagnyl-forte– film-coated tablets, heart-shaped, in dark glass bottles of 30 and 100 pcs.

Storage conditions

Shelf life – 5 years at temperatures not exceeding 25°C. The storage location must be protected from children, light and moisture. Over-the-counter release from the pharmacy.

Compound

Cardiomagnyl:
Active ingredients: acetylsalicylic acid – 75 mg, magnesium hydroxide – 15.2 mg.

Cardiomagnyl-forte:
Active ingredients: acetylsalicylic acid – 150 mg, magnesium hydroxide – 30.39 mg.

Auxiliary components: corn and potato starch, microcrystalline cellulose, talc, magnesium stearate, hypromellose, polyethylene glycol.

Additionally

Prescribe with caution for gout and hyperuricemia (reduces the excretion of uric acid).
Do not use before surgical interventions and in the postoperative period (risk of bleeding).
Patients with diabetes mellitus who take cardiomagnyl for a long time require correction of hypoglycemic agents (ASA causes hypoglycemia).
Do not use in combination with ibuprofen (neutralizing the therapeutic effect of ASA).
When taking glucocorticoids, it is possible to reduce the level of salicylates in the blood plasma; after discontinuation of glucocorticoids, salicylates increase (risk of overdose).
While taking Cardiomagnyl, monitoring of a clinical blood test is necessary.

Basic parameters

Name:	CARDIOMAGNIL
ATX code:	B01AC56 -

Cardiomagnyl is an anti-inflammatory, antiplatelet drug. Instructions for use recommend taking 75 mg tablets, the enhanced form of Forte 150 mg for the prevention of recurrent myocardial infarction, vascular thrombosis, cardiovascular diseases, and the prevention of thromboembolism after vascular surgery.

Release form and composition

Issued:

1. Cardiomagnyl tablets 75 mg po.
2. Tablets Cardiomagnyl Forte 150 mg po.

Tablets 75/15.2 mg are produced in the shape of a stylized “heart”, their color is white. Forte tablets are oval-shaped, white, with a score line on one side.

Cardiomagnyl contains 75 mg of acetylsalicylic acid and 15.2 mg of magnesium hydroxide; Forte contains active substances in a ratio of 150/30.39 mg, respectively.

Auxiliary components: magnesium hydroxide and stearate, corn and potato starch, MCC, talc, methyloxypropylcellulose 15, macrogol.

Pharmacological properties

The mechanism of action of acetylsalicylic acid is based on the ability of this substance to suppress platelet aggregation (sticking together), and therefore prevent the formation of blood clots. In addition, acetylsalicylic acid has analgesic, anti-inflammatory and antipyretic effects.

Magnesium hydroxide, which is part of the drug Cardiomagnyl, prevents the aggressive effects of acetylsalicylic acid on the mucous membrane of the gastrointestinal tract. Instructions for use (price, reviews, analogues of tablets will be discussed below in the article) informs that magnesium hydroxide does not affect the high bioavailability of acetylsalicylic acid, reaching 70%.

The half-life of acetylsalicylic acid is only 15 minutes, due to the fact that under the influence of enzymes this substance is quite quickly converted into salicylic acid, the bioavailability of which ranges from 80% to 100%, depending on the individual characteristics of the patient. The half-life of salicylic acid reaches three hours.

What does Cardiomagnyl help with?

Indications for use of the drug include:

1. unstable angina;
2. prevention of recurrent myocardial infarction and blood vessel thrombosis;
3. primary prevention of cardiovascular diseases such as thrombosis and acute heart failure in the presence of risk factors (eg, diabetes mellitus, hyperlipidemia, arterial hypertension, obesity, smoking, old age);
4. prevention of thromboembolism after vascular surgery (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty).

Instructions for use

Cardiomagnyl tablets are swallowed whole and washed down with water (if necessary, the tablet can be crushed).

To prevent primary cardiovascular diseases, one tablet containing 150 mg of aspirin is prescribed on the first day, after which a tablet containing 75 mg of aspirin is taken once a day. To prevent vascular thrombosis and recurrent infarction, one tablet is prescribed, containing 75-150 mg of acetylsalicylic acid - once a day.

According to the instructions, to prevent thromboembolism after vascular surgery, it is prescribed to take one tablet once a day, containing 75-150 mg of acetylsalicylic acid. Good reviews about Cardiomagnyl, used for unstable angina, one tablet containing 75-150 mg of aspirin once a day.

Contraindications

• 1st and 3rd trimesters of pregnancy;
• lactation period (breastfeeding);
• children and adolescents up to 18 years of age;
• tendency to bleeding (vitamin K deficiency, thrombocytopenia, hemorrhagic diathesis);
• hypersensitivity to acetylsalicylic acid, NSAID excipients of the drug Cardiomagnyl, from which the tablets can cause side effects;
• erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
• gastrointestinal bleeding;
• bronchial asthma induced by taking salicylates and NSAIDs;
• simultaneous use with methotrexate (>15 mg per week);
• deficiency of glucose-6-phosphate dehydrogenase;
• bleeding in the brain;
• severe renal failure (CK<10 мл/мин).

Side effects

• gastrointestinal bleeding;
• Quincke's edema;
• stomatitis;
• esophagitis;
• perforation of a gastric or duodenal ulcer;
• bronchospasm;
• anaphylactic reactions;
• anemia;
• heartburn;
• strictures;
• nausea, vomiting;
• drowsiness, insomnia;
• hives;
• colitis;
• headache;
• pain in the abdominal area;
• dizziness;
• ulcers of the mucous membrane of the stomach and duodenum;
• tinnitus;
• increased bleeding;
• hypoprothrombinemia, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis.

Children, pregnancy and breastfeeding

The use of Cardiomagnyl in high doses in the 1st trimester of pregnancy is associated with an increased incidence of fetal developmental defects.

In the 2nd trimester of pregnancy, salicylates should only be prescribed based on a strict assessment of risks and benefits.

In the 3rd trimester of pregnancy, salicylates in high dose(>300 mg per day) cause inhibition of labor, premature closure ductus arteriosus in the fetus, increased bleeding in the mother and fetus, and administration immediately before birth can cause intracranial hemorrhage, especially in premature infants. The administration of salicylates in the 1st and 3rd trimesters of pregnancy is contraindicated.

Salicylates and their metabolites are excreted in small quantities into breast milk. Accidental intake of salicylates during lactation is not accompanied by the development adverse reactions in a child and does not require cessation of breastfeeding.

However, with long-term use of the drug or when it is prescribed in a high dose, breastfeeding should be stopped immediately.

The drug is contraindicated for children under 18 years of age.

Special instructions

Long-term combined use of the drug with NSAIDs increases the risk of adverse reactions. In elderly people long-term use Cardiomagnyl increases the likelihood of developing gastrointestinal bleeding.

The product should be used with caution in allergy sufferers, patients bronchial asthma, with kidney/liver dysfunction, existing lesions of the gastric mucosa, dyspepsia.

Drug interactions

When used simultaneously, acetylsalicylic acid enhances the effect of the following: medicinal substances: methotrexate, heparin and indirect anticoagulants, thrombolytic and antiplatelet drugs (ticlopidine), digoxin, hypoglycemic agents: insulin and sulfonylurea derivatives, valproic acid.

Analogs of the drug Cardiomagnyl

Structural analogs of the active substance are not produced.

As a replacement, drugs containing acetylsalicylic acid:

1. Coplavix.
2. Godasal.
3. Agrenok.

Vacation conditions and price

The average price of Cardiomagnyl (table 75 mg, No. 30) in Moscow is 100 rubles. In Kyiv you can buy medicine (75 mg tablet, No. 30) for 52 hryvnia, in Kazakhstan - for 540 tenge. In Minsk, pharmacies offer Cardiomagnyl for 4-5 bel. rubles Dispensed from pharmacies with a prescription.

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The drug is classified as a medicine that prevents blood clots. When should you take Cardiomagnyl, morning or evening? Its main effect is to reduce the formation of blood clots in the lumen of blood vessels and prevent the occurrence of acute myocardial infarction, and the drug is also used in cases of impaired cerebral microcirculation with damage to brain tissue. The drug should be used according to the instructions for use.

"Cardiomagnyl": composition

The main active ingredient is acetylsalicylic acid; in addition to it, the drug also contains the following auxiliary components:

• magnesium hydroxide;
• potato starch;
• cellulose;
• a compound of magnesium salt and stearic acid.

"Cardiomagnyl" is sold in pharmacies in the form of tablets, which are packaged in bottles (30 or 100 pieces).

In pharmacies you can purchase a drug from the manufacturer “Nycomed” with different ratios of active ingredients:

1. In the first case, the tablets are produced in the shape of hearts. The ratio of acetylsalicylic acid and magnesium hydroxide is seventy-five and fifteen milligrams. The cost of thirty tablets is 150 rubles, the price of one hundred tablets is 260 rubles.
2. The second type is available in the form of oval tablets. Content active substances is one hundred fifty and thirty milligrams. The cost of "Cardiomagnyl" is 350 rubles.

For what diseases is the drug used?

The drug is effective in the fight against the following ailments:

1. To prevent recurrence of thrombosis, as well as after surgery, which helps to restore blood circulation in the arteries of the heart (using shunts).
2. With organic and functional lesions of the myocardium, which are caused by a lack of blood supply to the heart muscle.
3. With a focus of infarction developing as a result of acute damage to the coronary microcirculation.
4. With thrombosis (lifetime formation of clots inside blood vessels that impede the free flow of blood through circulatory system).
5. For headaches.
6. For serious and life-threatening pathological disorders of cerebral circulation.

The drug is also used to prevent heart and vascular diseases in patients over fifty-five years of age if they have diabetes mellitus, excessive weight gain and increased blood pressure. When to take Cardiomagnyl - is it best in the morning or evening?

Pharmacological action

The medicine belongs to the group non-steroidal drugs, which have anti-inflammatory and anti-thrombosis effects:

1. Acetylsalicylic acid reduces the rate of chemical reactions in the enzyme that is involved in the formation of prostanoids. In addition, the element inhibits the process of combining thromboxane A2, as a result of which the process of connecting blood clots stops and blood clotting decreases.
2. Magnesium hydroxide is considered the second important element, which is part of the drug. It helps protect the mucous membrane of the stomach and intestines, thereby reducing the risk of developing negative reactions(stomach ulcer, gastrointestinal hemorrhage).

Instructions for use

The medication is administered orally. Capsules must be taken whole with water. The drug can be taken regardless of nutrition, but, as a rule, to prevent adverse reactions, it is better to take the drug after meals:

1. For unstable angina, take one tablet containing acetylsalicylic acid in a dosage of 75 to 150 milligrams in the morning or evening.
2. When take Cardiomagnyl, to prevent recurrence of myocardial infarction, as well as thrombosis? If you have these diseases, the drug can be taken at any time of the day. Prescribe one tablet in a dose of up to 150 milligrams once a day.

How to take Cardiomagnyl for prevention?

To exclude the occurrence of acute blockage of blood vessels (thromboembolism) after surgery, take 1 tablet in the same dosage as for myocardial infarction.

For what disorders is the drug prescribed?

For primary prevention of heart diseases, Cardiomagnyl is prescribed in the presence of the following deviations:

• diabetes mellitus;
• hyperlipidemia;
• persistent increase in pressure;
• obesity;
• smoking.

When to take Cardiomagnyl - morning or evening? In such cases, one tablet of the drug is prescribed on the first day at a dosage of 150 milligrams, on the second day and subsequent days, one tablet at a dose of 75 milligrams at any time of the day. The duration of therapy depends on many factors, as well as the severity of the disease. In rare cases, Cardiomagnyl may be prescribed for life. The drug can be purchased at any pharmacy without a prescription.

According to reviews, Cardiomagnyl perfectly helps to cope with diseases of the heart and blood vessels, and also helps thin the blood. If you take the drug according to the doctor’s instructions and inform him about all aspects of your health, you can avoid the occurrence of side effects. Patients can take Cardiomagnyl in the morning and evening, whenever it is convenient for them.

One of the group representatives medicines non-steroidal type is Cardiomagnyl. It is used for both treatment purposes various diseases, and for their prevention. It is important to understand how the application of such medicine. In addition, an accurate determination of the duration of the course of treatment becomes a mandatory requirement. All these issues need to be given attention.

The proposed instructions determine different course durations. But it is still important to first find out in what situations the use of Cardiomagnyl can be beneficial. Most often, treatment with Cardiomagnyl is prescribed in such situations.

1. There is a need to improve the blood supply to the central nervous system. If the brain is experiencing oxygen deficiency, Cardiomagnyl will help get rid of this problem.
2. Angina pectoris. Correct use allows you to normalize your heart rhythm.
3. Thrombosis. In this case, Cardiomagnyl is prescribed primarily not for treatment, but for prevention. If you drink it correctly, you can significantly reduce the risk of blood clots.
4. History of heart attack. With the correct duration of treatment, Cardiomagnyl significantly reduces the risk of a recurrent heart attack. In this case, it is considered as a prophylactic drug.

In order for the result of application to be most successful, it is important to follow the instructions. It is worth turning to its consideration further. Then it will be clear how to use such a tool in a competent manner.

Instructions for the drug

First of all, you need to take into account that the use of such a serious drug must be prescribed by a doctor. It is he who determines the dosage, frequency, and course of treatment. You cannot prescribe such drugs yourself. This applies not only to this drug, and also to its analogues. But still, there are standard schemes that doctors rely on when determining treatment. In principle, you can use them as a “base” for application.

1. The recommended dosage of Cardiomagnyl is from 75 to 150 mg. It is usually one tablet taken after a meal.
2. Alternatively, you can take Cardiomagnyl in a crushed state. To do this, the tablet is first broken, thoroughly ground, and only then consumed.
3. The instructions say that there is no fundamental difference whether Cardiomagnyl is taken in the morning or evening. But doctors usually advise taking the medicine in the evening. This approach can be explained by the fact that it is with the onset of darkness that problems associated with the cardiovascular system worsen.

It is also necessary to warn that in some patients during treatment Cardiomagnyl causes increased sweating. That is, you should immediately prepare for certain inconveniences. But for the most part they are not critical. The most important thing is that this does not interfere with everyday life. By the way, for this reason, Cardiomagnyl is taken mainly in the evening.

Duration of Cardiomagnyl course

If there are no problems with determining the dosage and frequency of use of Cardiomagnyl, then difficulties sometimes arise regarding the duration of administration. This is explained by the fact that in each case Cardiomagnyl is prescribed individually. And usually the course turns out to be very large. It can be several months or even years. And in especially difficult cases, Cardiomagnyl has to be taken for life.

Therefore, it is not possible to say what the duration of treatment with Cardiomagnyl should be. Only a doctor can name the exact period. However, the duration of treatment may vary. To determine that Cardiomagnyl is working correctly, it is necessary to periodically measure blood clotting and constantly monitor blood pressure. If the doctor decides that there is no longer a need to use the drug, the course ends. But it will not be possible to determine that such a positive situation has developed without the help of a specialist.

From all this it follows that you need to approach taking Cardiomagnyl as responsibly as possible. Arbitrariness in this case is unacceptable. Even if the instructions for use are used, it will not be possible to protect against possible negative effects. And this is especially true when figuring out what the duration of treatment should be. The patient must be monitored by a physician at all times during use.