Essentiale forte or phosphogliv which is better reviews. Phosphogliv or Essentiale or Rezalut Pro - which is better? Composition and release forms
Unbalanced diet, desiring better environmental conditions, bad habits, overeating and, of course, infectious and viral diseases with a lot of antibiotics and other drugs consumed, inexorably and slowly kill the organs of every person. And most of all impacts fall on the body’s natural filter - the liver. It is this organ that has the fate of processing all harmful substances. They, in turn, unfortunately, have the ability to accumulate and lead to quite serious failures and diseases.
Doctors today have a sufficient number of drugs in their arsenal that can restore functional disorders liver function. These include: “Essentiale”, “Essliver”, “Rezodlut”, “Phosphogliv”. Useless dummies or a real panacea? How to understand and not make a mistake when choosing? Which is better to give preference to?
All of the listed drugs belong to the group of hepatoprotectors - drugs whose action is aimed at protecting and Which of the drugs should be preferred, which will be more effective - Phosphogliv or Essentiale capsules? What is best for maintaining an organ, what criteria should you pay attention to when choosing?
Indications for use
First of all, you should consider the indications for taking these drugs.
These hepatoprotectors are among the most popular today. It is these medications that doctors prescribe for the treatment of diseases such as cirrhosis, cystic fibrosis, toxic and infectious liver damage, and cholangitis. Also, these medications can be prescribed as maintenance therapy for dermatological problems.
But which drug to choose - Phosphogliv or Essentiale? What would be better suited as an effective immunomodulator that restores liver cells? It all depends on the severity of the patient’s condition and the form of the disease. In any case, it is only within the competence of a doctor to prescribe such a medicine, who will assess the overall picture of health using a series of tests.
Features of the composition
An equally important point is the composition. The main active component of the drugs are phospholipids.
Additionally, the drug "Phosphogliv" includes Her chemical structure is almost identical to the natural hormone of the adrenal cortex, which must be taken into account when taking high doses, because side effects can greatly undermine the condition. However, Phosphogliv is no worse than Essentiale, and when taking the recommended doses, the risk of developing serious consequences is minimized. Therefore, it is important that the dosage is determined by the doctor.
In this regard, the drug "Essentiale" is more gentle and safe. This fact is confirmed by relevant clinical studies. From here we can draw a certain conclusion regarding which drug to choose - “Phosphogliv” or “Essentiale”, which is better suited in each specific case.
Practice in children and adults
It is worth noting that the considered medicines not prescribed to children under 12 years of age. Due to the presence of glycyrrhizated acid in the composition of Phosphogliv, the capsules are prohibited for use during pregnancy. At the same time, the safer medication “Essentiale” is widely used to maintain the condition of pregnant women during periods of severe toxicosis and for other indications that require the participation of hepatoprotectors.
Regimen and dosage
There is an opinion that Phosphogliv is more effective than Essentiale. This can only be judged by the dosage active substance as part of these medications. And here there is also a plus in the direction of the second drug. It should also be noted that this medication contains fewer peroxidation products than capsules such as Phosphogliv. "Essentiale" - our health with minimal negative consequences. And this has been proven by a number of studies during the development and testing of the drug. Essentiale capsules are an excellent option for those patients who vitally need to take phospholipids in high dosages.
Side effects
It should be noted right away that pronounced side effects are indications for dose adjustment or complete discontinuation of the drug. When taking Phosphogliv, the following symptoms may appear:
- allergic reactions: rash, cough, conjunctivitis, difficulty breathing;
- Gastrointestinal disorders: nausea with vomiting, dyspepsia with belching and bloating;
- disorders of the cardiovascular system: edema, increased blood pressure.
The drug "Essentiale" is characterized by such side effects as softening of the stool, abdominal discomfort and allergic reactions due to intolerance to individual components.
Main differences between the drugs
Regarding which drug to choose (“Phosphogliv” or “Essentiale”), which is better suited for the treatment of each individual disease, only a qualified specialist can give an objective assessment. It should be remembered that self-medication is not best way to help your body cope with the disease, rather, it’s a direct way to harm. Therefore, consulting a doctor regarding the use of this or that medication is mandatory. All information presented above is for informational purposes only.
However, having considered the main differences between the two popular representatives of the hepatoprotector group of medications, we can highlight the following:
- the drug "Essentiale" is safer and can be used during pregnancy and in large doses;
- hepatoprotector "Phosphogliv" has a larger amount side effects, because it has a more saturated composition.
Otherwise, these medications are interchangeable and are analogues in this medicinal group of drugs.
Hepatoprotectors– a separate group of drugs that people learn about in exceptional cases. Representatives of this group are intended for the treatment and restoration of liver cells. They are prescribed for various diseases.
There are quite a lot of known hepatoprotectors. Each of the medications is good in its own way, and therefore it is quite difficult to say which is better - Phosphogliv, Silibor or, say, Hepafor. The principle of operation of all hepatoprotectors is almost the same. Still, some features distinguish some medications from others.
What is more effective - Essentiale or Phosphogliv?
Essentiale and Phosphogliv are a couple of the most popular modern hepatoprotectors. These are the ones that specialists prescribe most often. Both drugs are based on a mixture of phospholipids plant origin, extracted from soybeans. A properly selected composition helps restore and protect the liver. At the same time, both Phosphogliv and Essentiale can act as effective immunomodulators. All, without exception, hepatoprotective drugs prevent the destruction of hepatocytes - liver cells - and prevent the growth of connective tissues in the organ.
The main indications for the use of Phosphogliv or Essentiale are as follows:
- hepatosis;
- cirrhosis;
- cystic fibrosis;
- toxic liver damage;
- food infections;
- cholestasis;
Sometimes drugs are prescribed for dermatological diseases. In particular, Phosphogliv helps restore skin cells and eliminate inflammatory processes in them.
The duration of treatment with Phosphogliv Forte or Essentiale may vary. For some patients, one course is enough, while others are forced to take hepatoprotectors throughout their lives. It all depends on general condition the patient’s health, the form of the disease, its stage.
The difference between Essentiale Forte and Phosphogliv - in excipients Oh. In addition to phospholipids, Phosphogliv contains glycyrrhizic acid. The chemical structure of the latter makes it similar to the hormones of the adrenal cortex. For this reason, too large doses of Phosphogliv can lead to quite serious side effects. And this fact must be taken into account.
Even the most detailed comparative characteristics will not give an unambiguous answer to the question of which is better - Phosphogliv or Essentiale Forte. The drugs adequately replace each other. The only recommendation is to give preference to Essentiale in cases where treatment requires taking a large amount of phospholipids.
Phosphogliv or Essentiale - which is better for hepatitis?
The selection of medications for hepatitis must be very careful. And even taking this into account, it is difficult to make a choice in favor of one or another drug. The fact is that Phosphogliv is ideal for some patients. The medication inhibits the development of fibrosis and 
enhances the effect of antiviral drugs. While other patients with hepatitis do not feel the effects of Phosphogliv at all, but after Essentiale their well-being improves significantly.
The problem is that there are many types of hepatitis. And in different organisms, each of them develops uniquely. It is quite possible that both Phosphogliv and Essentiale may be suitable for one patient, while another will have to go through all sorts of drug analogues. Therefore, suitable medications can only be selected after a detailed examination.
Many believe that liver problems are caused by alcohol abuse. However, this is not entirely true. We absorb pollutants in our air and food every day. Poor diet and medications also have a negative impact on the liver. But it's not all bad. How to effectively support liver regeneration? Which is better - Phosphogliv or Essentiale?
Which drug to choose to restore the liver?
The liver is one of the most important human organs when we're talking about about maintaining health. The amount of toxins that are filtered daily through liver cells from the blood increases steadily throughout our lives. In addition to the body's internal toxins, alcohol, nicotine, drugs and medications of all kinds place a huge burden on the liver.
In addition, intestinal problems such as bloating, pesticides in food, and pollutants do not contribute to health. environment substances - heavy metals in drinking water and much more.
The sooner you help your liver build cells and repair them naturally, the sooner your entire body will benefit. A separate group of drugs called hepatoprotectors serves precisely these purposes. They stimulate the regeneration of damaged liver cells, normalize its functioning and protect against the harmful effects of harmful substances.
Read also:
Today, the pharmaceutical market is saturated with similar drugs, both domestic and foreign. “Phosphogliv” and “Essentiale Forte N” are especially popular, and now we’ll find out which one is better.
|
"Essentiale" |
"Phosphogliv" |
|
The drug is quite unique, first of all, due to its high content of essential phospholipids. They are the ones who participate in cell restoration and normalization of metabolism. The medicine reduces the intensity of replacement processes of healthy cells by connective tissues. |
An active combined hepatoprotector, which includes, in addition to phospholipids, glycyrate. This substance provides the immunomodulatory properties of the drug, suppressing the development of viruses and stimulating the production of interferon. |
|
Indications and contraindications |
|
|
Used for degenerative fatty liver lesions, including diabetes, intoxication, cirrhosis, hepatitis various forms, cellular tissue necrosis, psoriasis, hepatic coma. The drug is contraindicated in case of hypersensitivity to the components included in its composition. |
Capsules are prescribed for the treatment of chronic viral hepatitis and liver cirrhosis. The drug is used in the complex treatment of eczema, psoriasis, neurodermatitis, acute intoxication of the liver and the body as a whole. The medicine is not prescribed to children under 12 years of age and pregnant women. During lactation, its use is possible only with suspension breastfeeding. |
|
Advantages |
|
|
|
|
Flaws |
|
|
Possible side effects such as allergies, abdominal pain, diarrhea. |
|
What analogues are there?
In addition to the two drugs discussed, pharmacy chains offer a large selection of medicines that are analogues of Phosphogliv and Essentiale:
- "Heptral" is a hepatoprotector with antidepressant properties, has a neuroprotective, antioxidant, and detoxifying effect. Actively stimulates recovery processes in the liver.
- “Karsil” is used both for the regeneration of liver tissue and for the prevention of pathological changes.
- "Hofitol" is a herbal hepatoprotector with a choleretic effect. In addition, the drug has a moderate diuretic effect. And the therapeutic effect of the medicine is provided by artichoke leaf extract.
Introduction
The use of essential phospholipids (EP) as part of hepatoprotective drugs has a history of forty years. The main active substance is a mixture of phospholipids isolated from soybeans and comprising from 30 to 70% of the total mixture of phosphatidylcholine (PC). Other ingredients include phosphatidylethanolamine, lysophosphatidylcholine, phosphatidylinositol, triglycerides. One of the main mechanisms of action of PC, discussed in the literature, is the restoration of the structure of liver cell membranes, which are approximately 75% (mitochondrial membranes are 92%) composed of PC, which forms a bilayer. PC maintains normal membrane fluidity and repair, acts as an antioxidant, protects mitochondrial and microsomal enzymes from damage, slows down collagen synthesis and increases collagenase activity.
If this is the main mechanism of action of EFs, then their effectiveness in the production of hepatoprotective drugs should depend on the amount of PC contained. In addition, during storage and processing of EP, accumulation of peroxide oxidation products occurs.
In addition to EF, hepatoprotective drugs may contain other substances that affect the effectiveness and mechanism of their drug action. Important for practicing doctors comparative assessment preparations based on phospholipids, allowing to identify the areas of application of each of them.
In this work, three drugs containing PC were studied: “Essentiale Forte N” produced by Sanofi-aventis, “Essliver Forte” produced by Nabros Pharma Pvt. Ltd., India (packaged at Nizhpharm OJSC, Russia) and Phospho-gliv produced by Pharm-standard - Leksredstva OJSC, Russia. A comparative assessment of the drugs in this work was carried out based on data on the PC content and the accumulation of PC peroxidation products.
Experimental part
Analysis of accumulation of peroxidation products
The accumulation of peroxidation products was determined by the content of aldehydes (malondialdehyde) relative to thiobarbituric acid (TBA). To determine the content of TBA-sensitive products (TBASP), we used the traditional method of spectrophotometric determination of the reaction products of TBA with substances contained in the studied preparations
The contents of the drug capsules were transferred to flasks, chloroform was added, mixed and left for extraction overnight. The chloroform extract was transferred to another flask and the solvent was removed. A lipid extract was obtained from these preparations, which was dissolved in alcohol and a solution of a mixture of thiobarbituric and trichloroacetic acids was added to it. The samples were heated at boiling for 30 min. Next, the solutions were analyzed spectrophotometrically, measuring absorption at wavelengths of 580 and 532 nm. The content of TBCCP was calculated using the formula:
C = (D532 - D580) . 6 . 1000/155
The results of 3 experiments are presented in Table 1. It was found that the drug “Essential Forte N” contains the smallest amount of TBCCP, and the drug “Essliver Forte” contains the largest amount (Table 2).
Phosphatidylcholine was detected in all samples. However, in the Essliver Forte sample, in addition to it, other phospholipids are also present. Substances of a non-phospholipid nature were recorded in all three samples, but in “Essliver Forte” their quantity is higher
Discussion of results
All studied drugs have different maximum daily doses of EF. All of them are made in Germany. The PC content in the studied drugs is presented in Table 3.
The maximum recommended daily dose of PC in Essential Forte N exceeds that of Essential Forte and more than 2 times that of Phosphogliv. "Phosphogliv" contains the second active component of trisodium salt of glycyrrhizic acid (35 mg per capsule). Glycyrrhizic acid (glycyrate) is isolated from the extract of licorice (licorice) roots and belongs to the steroid saponites. The glycyrrhizic acid molecule has a fragment similar in structure to hormones produced by the adrenal cortex (cortisone, etc.). Therefore, the use of glycyrrhizic acid in doses exceeding therapeutic doses leads to serious side effects.
It should not be ignored that glycyrate used orally for a long period (more than 6 weeks) can cause symptoms of intoxication: headache, lethargy, high blood pressure, swelling, removal of potassium from the body and even cardiac arrest. These side effects are similar to corticosteroid medications and are due to the fact that glycyrate interferes with the breakdown of natural adrenal steroids in the body. Thus, drugs containing glycyrrhizic acid should be classified as strictly prescription drugs.
In addition to EF, the drug "Essliver Forte" contains a number of vitamins (B1, B6, B12) in fairly high doses. Therefore, pharmacologists do not recommend it for long-term use (more than 2 weeks) due to the occurrence of negative side effects: allergic reactions, the development of fatty liver disease and hypervitaminosis.
"Essentiale Forte N" has the highest dosage of PC in the maximum recommended daily dose in the absence of additional active ingredients that have side effects. Hepatoprotective activity is achieved mainly through the restoration of liver cell membranes; this process is practically not accompanied by side effects.
Analysis of the accumulation of peroxidation products shows that the lowest content is observed in Essential Forte N, and the highest in Essliver Forte. The process of accumulation of peroxide oxidation products is determined by: parameters of the EP isolation technology, conditions of its storage, parameters of production technology ready-made form drug, storage conditions of the drug. Since the source of EP for the described drugs is produced in Germany, then, apparently, the accumulation of peroxidation products depends only on the conditions of transportation and storage of the starting materials and the parameters of production and storage of the finished products. dosage forms drugs. Consequently, only Essentiale Forte N, produced in Germany, can contain the least amount of peroxidation products, because the production of raw materials and finished products is as close as possible geographically, and EF as a raw material has a short shelf life. Production in Ufa (Phosphogliv) and Nizhny Novgorod (Essliver Forte) cannot have such conditions, and as a result these products have a higher content of peroxidation products.
The accumulation of peroxidation products, especially malondialdehyde, results when applied to intermolecular cross-links with proteins. This process occurs uncontrollably, the result is allergic reactions, a load on the liver when they are disposed of in the body. The content of peroxidation products should affect the rate and pathway of EP metabolism in the human body.
Conclusions
1. When comparative analysis accumulation of peroxidation products in the studied preparations, it was shown that “Essentiale Forte N” has the lowest content of peroxidation products, and their highest content was noted in the preparation “Essliver Forte”.
2. Based on the analysis of our own results and literature data, we can conclude that the drugs being compared have different mechanisms of biological active and side effects:
. "Essentiale Forte N" is a one-component drug with high content polyunsaturated phosphatidylcholine, the main mechanism of biological activity of which is the restoration of liver cell membranes;
. "Essliver Forte" is a drug with a low content of phosphatidylcholine, the biological activity of which is complemented by the B complex of vitamins included in its composition. However long-term use this complex can negatively affect the treatment of fatty liver and cause allergic reactions;
. “Phosphogliv” is a drug with a low PC content, the biological activity of which is complemented by the presence of glycyrrhizic acid in its composition. However, this supplement is used when treating with the drug for more than 6 weeks. can cause a number of symptoms of intoxication.
ru.pch.10.03.25
Literature
1, F.D. Gunstone, F.B. Padley. Lipid Technologies And Applications. New York, 1997.
2.I.A. Vasilenko, Yu.M. Krasnopolskij, A.E.Stepanov and V.I. Shvets. Problems and prospects of phospholipid production. Pharmaceutical Chemistry Journal, 1998.
3. Guidelines for experimental (preclinical) study of new pharmacological substances. Under the general editorship of Corresponding Member. RAMS prof. R.U. Khabrieva. M.: 2005.
4. N. Abe, T. Ebina, N. Ishida. Interferon induction by glycyrrhetinic acid in mice. Microbiol. Immunol., 1982, 26, p.535.
5. M. Shinada, M. Azuma, H. Kawai et al. Enhancement of interferon-γ production in glycyrrhizin-treated human peripheral lymphocytes in response to concanavalin A and to surface antigen of hepatitis B virus. Proc. Soc. Exp. Biol. Med., 1986, 181, p.205.
6. Krahenbuhl S., Hasler F., Frey B.M. et al. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J. Clin. Endocrinol. Metab., 1994, 78, p.281.
7. Y. Arase, K. Ikeda, N. Murashima, K. Chayama et al. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer, 1997, 79(8), p.1491.
8. K. Miyake, T. Tango, Y. Ota et al. Efficacy of Stronger Neo-Minophagen C compared between two doses administered three times a week on patients with chronic viral hepatitis. J. Gastroenterol. Hepatol., 2002, 17(11), p.1198.
9. L. Zhang, B. Wang. Randomized clinical trial with two doses (100 and 40 ml) of Stronger Neo-Minophagen C in Chinese patients with chronic hepatitis B. Hepatology Research, 2002, 24(3), p.220.
10. A. Tsubota, H. Kumada, Y. Arase, K. Chayama, S. Saitoh, K. Ikeda, M. Kobayashi, Y. Suzuki, N. Murashima. Combined ursodeoxycholic acid and glycyrrhizin therapy for chronic hepatitis C virus infection: a randomized controlled trial in 170 patients. European journal of gastroenterology & hepatology, 1999, 11(10), p.1077.
11. H. Kumada. Long-term treatment of chronic hepatitis C with glycyrrhizin for preventing liver cirrhosis and hepatocellular carcinoma. Oncology, 2002, 62(1), p.94.
12. D.S. Molokovsky, E.V. Esaulenko, O.O. Pavlova. Chronic hepatitis C: principles and prospects of herbal medicine. Infectious diseases, 2006, 7, p. 320.
To identify liver diseases, it is necessary to undergo timely diagnosis, since the first stages of the disease are often asymptomatic. For this purpose, research methods such as liver biopsy, computed tomography and magnetic resonance imaging (CT and MRI), and ultrasound examination (ultrasound) are used.
The market for pharmaceutical drugs for the liver is so wide that patients are sometimes confused about the medications offered. Phosphogliv and Essliver were unjustifiably considered analogues for some time. But both the effect on the body and the results from taking these medications are different. So which is better? Phosphogliv or Essliver? Let's try to figure it out.
Differences in composition
Both drugs belong to the group of hepatoprotectors - medications that protect liver cells. Phosphogliv or Essliver is prescribed for the treatment of inflammatory and viral diseases liver and for the prevention of its pathologies.
Why is it so important to understand which hepatoprotector is right for you? The fact is that the difference in composition, indications, contraindications and pharmacological properties of these medications may affect the outcome of treatment.
To figure out which is better - Phosphogliv or Essliver, let's look at their composition.
Both drugs are based on phospholipids, but Essliver contains 29% phosphatidylcholine, and in Phosphogliv 76%.
Phosphogliv additionally contains glycyrrhizic acid (GA), and Essliver contains a complex of vitamins.
The combination of phospholipids and HA is included in the standards of care medical care. The presence of these two substances in the composition helps the medicine to be better absorbed.
Glycyrrhizic acid is an extremely important component. It has anti-inflammatory, antioxidant and antifibrotic effects.
According to the state register of medicines, Phosphogliv is the only hepatoprotector that includes glycyrrhizic acid, so we can conclude that there are no analogues to Phosphogliv on the domestic market Essliver, in turn, in addition to phospholipids, contains vitamins B1, B2, B6, B12 and PP – these biologically active substances are designed to speed up metabolism. But it is worth remembering that long-term use of the drug can cause hypervitaminosis - vitamin poisoning. An overdose of vitamin B6 provokes pathologies of the cardiovascular and nervous systems, disrupts coordination of movements. Therefore, it would not be an exaggeration to question the effectiveness and safety of uncontrolled use of Essliver.
Phosphogliv, unlike Essliver, is a hepatoprotector with a proven anti-inflammatory effect.
Differences in indications
Phosphogliv or Essliver can also be taken to treat the overgrowth of fatty, connective and scar tissue in the liver. Prevention Mechanism pathological process hepatoprotectors are similar due to the presence of both phospholipids in the composition, however, one should not forget about the anti-inflammatory effect of Phosphogliv due to glycyrrhizic acid, which Essliver, unfortunately, does not have in its composition.
Both drugs are used as part of a combination treatment for psoriasis. To remove the breakdown products of dangerous compounds after an overdose of alcohol or drugs, adsorbents are prescribed ( activated carbon) and a hepatoprotector, for example, Phosphogliv. Essliver is not effective in this case, but it is used for poisoning with high doses of radiation.
For toxicosis in pregnant women, Essliver is prescribed. The mechanism of action of Phosphogliv on the health of women and fetuses has not been fully studied. Besides, vitamin complex, which is part of Essliver, allows the drug to be used to prepare the body for surgical interventions. This drug is also prescribed during the rehabilitation period after operations.
Reception features
Both medications have their own contraindications and peculiarities of administration, when therapy should be carried out under the supervision of a physician. Phosphogliv or Essliver should be taken with caution if you are prone to allergies and intolerance to phospholipids (antiphospholipid syndrome).
Phosphogliv is not used to treat children under 12 years of age, pregnant or lactating women. This is due to the lack of information about the effectiveness and safety of the drug in these groups of patients.
Essliver should be taken with caution by patients with diseases of the heart and blood vessels, kidneys, stomach ulcers and duodenum, neoplasms, kidney stones, a tendency to excessive blood clotting. The drug should not be used by people with high levels of uric acid and erythrocytes (red blood cells). A relative contraindication is erythremia, a pathology in which the formation of shaped elements blood.
Because of these features, the circle of patients for whom Essliver is indicated without fear of side effects is significantly narrowed. You should not use the drug if you are not sure of your own diagnosis.
So which is better - Phosphogliv or Essliver? The undoubted advantage of Phosphogliv is its unique formula, which allows it to be better absorbed, and not only restore the liver, but also treat it. Essliver, combining phospholipids and a vitamin complex, calls into question its effectiveness due to the fact that vitamins, if taken uncontrolled, can play a cruel joke on a person.
In any case, only your attending physician can tell you what is best for you based on your medical history, symptoms and diagnostic results. Be careful when choosing a medication and take medications only according to the instructions!
lookmedbook.ru
What is the difference between Phosphogliv and Essentiale?
At first glance, the drugs are similar - both are hepatoprotectors. Both have a common substance: essential phospholipids, which strengthen liver cells.
What's the difference? What to choose - Phosphogliv or Essentiale?
It is especially worth noting the composition of Phosphogliv. In addition to essential phospholipids, it contains glycyrrhizic acid. It is this combination of substances that is included in the standards of medical care. And Phosphogliv is the only hepatoprotector that contains glycyrrhizic acid. It is she who has an anti-inflammatory effect and acts on the very cause of liver destruction.
Main active ingredient:
Phosphogliv - (essential phospholipids, glycyrrhizic acid);
Essentiale - (essential phospholipids);
Indications for use:
Phosphogliv - (fatty liver degeneration (hepatosis), alcohol, toxic, including drugs, liver damage, in complex therapy viral hepatitis, cirrhosis, psoriasis);
Essentiale - (fatty liver degeneration (hepatosis), toxic liver damage, psoriasis, cirrhosis);
Contraindications:
Phosphogliv - ( increased sensitivity to the components of the drug, pregnancy (insufficient data), breastfeeding period (insufficient data));
Essentiale - (hypersensitivity to the components of the drug, newborns, pregnancy, breastfeeding);
Side effects:
Phosphogliv - (Extremely rare (1 case in 10,000), allergic reactions, abdominal discomfort, increased blood pressure);
Essentiale - (stomach pain, slight looseness of stool, diarrhea, allergic reactions in the form of rash and urticaria);
Patient reviews of the drugs
When choosing a drug, you should carefully study the direct experience of those who have already undergone treatment with Phosphogliv or Essentiale. Of course, each person has an individual reaction to the medicine, but you can learn about some of the peculiarities of taking it and the results from reviews.
Patient reviews of Phospholiv
Victor, 36 years old
I was in the hospital for a long time and took a lot of medications. A constant has appeared It's a dull pain in the side. The doctor added Phosphogliv to the treatment, and soon all the unpleasant sensations stopped. According to the test results (taken two months later), everything is fine.
Ekaterina, 45 years old.
Relaxed. In a couple of years I gained 15 kilograms. She ate everything, and if there was something fried in mayonnaise, she attacked it. I also didn’t limit myself to alcohol. And at some point I felt discomfort. I began to notice external changes - my facial skin and hair had deteriorated. I thought it was age. But just in case, I went to the hospital and got tested. They prescribed Phosphogliv and a diet.
Four months later everything returned to normal. According to analyses. And after a month it felt much easier.
Alla, 25 years old.
I never thought about my liver. And who thinks about it at 25 years old if it doesn’t hurt? I rented it out complex analyzes– I undergo a full inspection every year. And something alerted my attending physician. He asked me to drink Phosphogliv. Despite the fact that nothing worried me, I did not want the disease to develop. There were no unpleasant side effects during the course. And as a result, I even felt somehow better, although before that I was not bad.
Patient reviews about Essential
Olga, 27 years old.
There was a period in my life when it was completely impossible to eat normally. Constant fast foods, snacks on the go. And I was prescribed Phosphogliv or Essentiale. I decided to take the second drug, and, unfortunately, it didn’t quite suit me personally - on the one hand, judging by the tests, it helped the liver, on the other hand, I had side effects, my stomach hurt. I had to cancel and switch to Phosphogliv.
Alexey, 32 years old.
I took Essentiale. I didn’t feel much difference before and after. Although the doctor says that this is normal, my liver has not yet reached a painful state, but I should have felt at least some improvement.
Nikolai, 51 years old.
Throughout my life I have not been distinguished by exemplary behavior. And a drink and a beer on the weekend. And I love to eat - my wife cooks very well. Maybe not exactly healthy food, as is fashionable now, but very tasty. Not long ago I felt discomfort in my side. The neighbor said that he had this and helped Essentiala. Well, I bought it too. And I gave it up halfway through the course because I didn’t feel any effect. I went to the doctor, and there he figured out what was what and what would help my liver.
medportal.su
Drug names
Phosphogliv is the commercial name of the drug. There is also a group name that sounds like this: phospholipids + glycyrrhizic acid. The chemical name Phosphogliv is correctly written as follows: phosphatidylcholine + trisodium salt of glycyrrhizic acid.
Composition and release forms
Today, the drug Phosphogliv is available in capsule form.
Phosphogliv capsules have a hard gelatin shell, the body of which is colored orange and the cap is black. Inside the capsules there is granular powdery contents, colored white with a yellowish tint, and having a specific odor. Phosphogliv is sold in packages of 30, 50, 100, 200 or 300 capsules.
Phosphogliv contains two active substances, This:
1.
Phospholipids (Lipoid C 80) (of which phosphatidylcholine makes up 73-79% of the substance) - 65 mg.
2.
Trisodium salt of glycyrrhizic acid - 35 mg.
In addition, the drug contains a number of excipients, This:
- microcrystalline cellulose;
- calcium carbonate;
- calcium stearate;
- talc;
- colloidal silicon dioxide.
The capsule body consists of the following substances:
- sunset yellow dye;
- titanium dioxide;
- gelatin.
The capsule cap consists of the following substances:
- iron oxide black dye;
- titanium dioxide;
- gelatin.
Photo of the drug packaging
Phosphogliv forte
There is also a type of drug called Phosphogliv Forte. It is produced in the Russian Federation, in the city of Kursk.
Pharmacological properties of the drug
The therapeutic effects of Phosphogliv are due to the phospholipids and glycyrrhizic acid that are part of it.
Thus, phosphatidylcholine (the main substance phospholipids) is a necessary structural component of the membranes of any cell. Thus, by influencing the state of cell membranes, phosphatidylcholine exhibits cytoprotective properties. Phosphatidylcholine also normalizes lipid and protein metabolism, prevents the loss of enzymes and other substances by liver parenchyma cells, normalizes the detoxifying function of the organ, suppresses the formation of connective tissue, reducing the likelihood of developing fibrosis and cirrhosis of the liver.
Glycyrrhizic acid has an anti-inflammatory effect, inhibits the proliferation of viruses in the liver and other organs by increasing the production of interferons, increasing phagocytosis, and also enhancing the activity of natural killer cells. Exhibits hepatoprotective properties due to its antioxidant and membrane-stabilizing effects. By enhancing the effect of endogenous glucocorticoids, it has an anti-inflammatory and antiallergic effect in liver lesions not associated with infection.
In case of lesions of the skin, it prevents an increase in the area of the lesion and helps to cure the pathology by stabilizing cell membranes and stopping the inflammatory process.
Indications for use
Phosphogliv is used for the following diseases:
- Fatty liver degeneration;
- Alcohol, toxic (including drug) liver damage;
- As part of the complex treatment of acute and chronic viral hepatitis, liver cirrhosis and psoriasis.
Phosphogliv capsules - instructions for use
Capsules are taken orally during meals, without chewing, with clean water.
For children over 12 years of age and adults, it is optimal to take two capsules 3 times a day. The duration of the course of taking Phosphogliv can be no more than six months, on average - 3 months.
Overdose Phosphogliv was not detected even once during the entire period of use of the drug.
Interaction with other medications was also not established.
Special instructions: If your blood pressure increases, you should stop taking the drug and consult your doctor.
Use during pregnancy
Phosphogliv capsules and lyophilisate are contraindicated for use by pregnant women. However, women suffering from chronic hepatitis or hepatosis are prescribed a course of Phosphogliv, if necessary. But in such situations, the benefits of using the drug should exceed all possible side effects.
Infectious disease doctors developed countries Europe and the USA prefer not to prescribe Phosphogliv during pregnancy, because this drug activates immune mechanisms. Normally, a pregnant woman's immunity is slightly reduced, which is necessary for bearing a fetus. After all, if the immune system remains normal, then the woman will not be able to bear a child, since the immune system will cause miscarriages, considering the fetus to be some kind of foreign genetic material. That is, increased activity immune system causes an increased risk of miscarriage. That is why it is better not to use Phosphogliv during pregnancy.
Phosphogliv for children
According to the instructions for use, Phosphogliv is used in children from 12 years of age. In this case, children over 12 years of age take the drug in adult dosages - 2 capsules 3-4 times a day.
Phosphogliv is contraindicated for use in children under 12 years of age.
Phosphogliv for hepatitis C
Phosphogliv for hepatitis C is prescribed to maintain the functional activity of the liver, as well as to reduce the rate of development of fibrosis. In this case, it is usually recommended to use the drug before starting antiviral therapy. Hepatologists consider it necessary to take Phosphogliv 2 capsules three times a day, for 1 year or until the start of antiviral therapy.
However, it should be remembered that Phosphogliv can exclusively reduce the activity of AST and ALT, maintain normal liver function and prevent the development of fibrosis. But it is not a drug that can cure a person from hepatitis C. This type of hepatitis is treated exclusively antiviral drugs, and Phosphogliv can be included in complex therapy as a means that effectively normalizes liver function.
Interaction with alcohol
Alcohol negatively affects the liver, increasing inflammatory and degenerative processes. On the contrary, Phosphogliv normalizes the functioning of the organ and restores cell integrity. That is why alcohol is contraindicated when using Phosphogliv. But if necessary, during treatment with Phosphogliv, you can drink a small amount of alcohol, since there is no chemical antagonism between these substances. Small quantity allowed alcoholic drinks in between courses of taking a hepatoprotector.
Side effects
In the vast majority of cases, Phosphogliv does not cause adverse reactions and is well tolerated by patients. Very rarely, the drug can cause the following side effects:
Allergic manifestations:
- skin rash;
- difficulty in nasal breathing;
- conjunctivitis;
- cough.
Heart and blood vessels:
- temporary increase in blood pressure;
- peripheral edema.
Digestive system:
- dyspeptic symptoms (belching, nausea, flatulence);
- discomfort in the stomach.
If the above side effects occur, you should stop the drug and consult a doctor.
Contraindications
Phosphogliv has contraindications, including absolute and relative. If there are absolute contraindications, the drug cannot be used in principle. And against the backdrop of existing relative contraindications Phosphogliv can be used, but with caution and under close medical supervision of the person’s condition.
Absolute contraindications to the use of Phosphogliv:
- Hypersensitivity to the components of the drug;
- Pregnancy;
- Breastfeeding;
- Age under 12 years.
Relative contraindications:
- Portal hypertension;
- arterial hypertension.
Analogs
Phosphogliv is an original drug that has no analogues. However, today there are a number of medicines on the domestic pharmaceutical market that, like Phosphogliv, contain essential phospholipids as active ingredients. Among them:
- Brenciale forte – capsules;
- Livolin forte – capsules;
- Lipostabil - capsules and solution;
- Rezalut Pro – capsules;
- Phosphatidylcholine – capsules;
- Phosphonziale - capsules;
- Essel forte - capsules;
- Essentiale, Essentiale N, Essentiale forte, Essentiale forte N – capsules and solution for intramuscular injection;
- Essliver forte - capsules.
In addition, there are a number of hepatoprotectors that have a similar range of therapeutic effects, but contain different chemical compounds as active components:
- Hepa-Merz – granules for the preparation of a solution for oral administration and a concentrate for the preparation of a solution for intravenous administration;
- Gepatosan – capsules;
- Gepafor - capsules;
- Heptrong – solution for intramuscular administration;
- Glutargin – concentrate and solution for intravenous administration;
- Glutargin – tablets and powder for the preparation of solution for oral administration;
- Dipana - tablets;
- Potassium orotate – tablets and granules for making syrup;
- Karsil - dragee;
- Karsil Forte – capsules;
- Cryomelt MN – solution for subcutaneous administration;
- Laennec – solution for injection;
- Legalon 140, Legalon 70 – capsules;
- Liv.52 – tablets and drops for oral administration;
- Maksar - tablets;
- Methionine – tablets;
- Metrop GP – solution for subcutaneous administration;
- Peponen – capsules;
- Progepar - tablets;
- Remaxol – solution for intravenous administration;
- Ropren – drops for oral administration;
- Rosilymarin – tablets;
- Silibinin – tablets and dry extract;
- Silibor – tablets;
- Silimar – tablets and dry extract;
- Silymarina Sediko – granules for the preparation of a suspension for oral administration;
- Thiotriazolin - tablets and solution for intravenous and intramuscular administration;
- Tykveol – capsules, rectal suppositories and oil for oral administration;
- Pumpkin seed oil;
- Cholenol – capsules;
- VG-5 – tablets.
Reviews
Most of the reviews about Phosphogliv (about 4/5) are positive, which is due to the good effectiveness of the drug and its relative cheapness. People who took Phosphogliv noted that the drug has excellent hepatoprotective properties, eliminating unpleasant symptoms associated with liver dysfunction. Patients also noted the excellent effect of the drug during maintenance therapy for hepatitis C. Thus, biochemical indicators, such as the concentration of bilirubin and the activity of liver enzymes - AST, ALT and alkaline phosphatase, were normalized in people, which made it possible to maintain the liver in good functional condition while awaiting a course of antiviral therapy .
In addition, Phosphogliv has greatly helped people suffering from skin diseases. Many people noted that after a course of using Phosphogliv, the condition of the skin significantly improved, including the disappearance of acne and small pimples.
Negative reviews Only less than 20% of people who used Phosphogliv reported the drug. Negative reviews are due to the fact that the drug did not help these specific people get rid of liver problems.
Reviews from doctors
Hepatologists and infectious disease specialists generally speak positively about Phosphogliv. It is especially often prescribed in the complex therapy of hepatitis C, since the drug has a pronounced positive action on the liver and significantly inhibits viral replication activity. Japanese doctors prescribe Phosphogliv to all patients suffering from hepatitis C before starting antiviral therapy, since the drug in some cases even completely cures the disease and stops the replication of the virus. That is why hepatologists speak positively about Phosphogliv in relation to hepatitis.
Doctors also speak positively about Phosphogliv as a hepatoprotector, which is used for any liver damage of toxic, drug or alcohol origin, and for hepatosis. In these conditions, the drug normalizes biochemical tests, liver condition, and also significantly improves a person’s overall well-being. Doctors note that complex therapy various diseases liver with the use of Phosphogliv normalizes the condition of the organ faster than without the use of this hepatoprotector.
Dermatologists who use the drug in the treatment of various skin diseases, including psoriasis, speak positively about Phosphogliv. Phosphogliv helped many girls and women get rid of pimples and acne, normalizing the condition of the liver and increasing its ability to neutralize toxic substances.
Negative reviews from doctors about Phosphogliv can only be seen in relation to specific treatment regimens. If in such schemes the doctor considers Phosphogliv unnecessary, then he expresses a negative opinion. However, in general, the drug is not considered bad; we are only talking about the inappropriateness of use in this particular case.
Phosphogliv or Essentiale?
Both Essentiale and Phosphogliv are hepatoprotectors and contain phospholipids as active components. At the same time, Essentiale contains exclusively phospholipids, and Phosphogliv also contains glycyrrhizic acid. This acid is a steroid saponin in its chemical structure, that is, it is close in structure to the hormones of the human adrenal cortex (the properties of glycyrrhizic acid and its effect on the liver are described above). However, this difference in the composition of drugs is not always a criterion for choosing one of them. Each person's body is unique, and one patient will be better suited to Phosphogliv, and another - Essentiale. Therefore, before choosing a hepatoprotector and its dosage, you should consult your doctor.
It should also be noted that Essentiale contains lipid peroxidation products, while Phosphogliv does not contain these compounds.
More information about the drug Essentiale
Heptral or Phosphogliv?
According to the latest orders of the Ministry of Health of the Russian Federation, Phosphogliv is one of the standard drugs for providing specialized medical care for acute hepatitis C of severe and moderate severity, as well as for chronic hepatitis C. In turn, Heptral is not included in this list of drugs. Thus, we can conclude that for chronic hepatitis C, as well as for severe and moderate acute hepatitis C, Phosphogliv should be preferred.
At the same time, Heptral is more effective drug for the treatment of ALD and toxic hepatitis. Therefore, for these diseases, Heptral should be preferred.
Otherwise, the drugs Heptral and Phosphogliv are comparable in terms of therapeutic effectiveness. Therefore, you can use any drug that, for some subjective reason, a person likes more. However, we should not forget that each person’s body is individual, so Heptral may be well suited for one patient, while Phosphogliv may be suitable for another.
More information about the drug Heptral
Price in Russia and Ukraine
The different prices for Phosphogliv in retail pharmacies are due to trade margins, as well as the costs of transportation and storage of drugs. Approximate prices for Phosphogliv in pharmacy chains in Russia and Ukraine:
In Russia: Phosphogliv, 65 mg + 35 mg, 50 capsules – 404 – 478 rubles.
In Ukraine: Phosphogliv, 65 mg + 35 mg, 50 capsules – 103 – 137 hryvnia.
www.tiensmed.ru
Which is better Phosphogliv or Essentiale - comparative characteristics
The hepatoprotective group of drugs is aimed at restoring liver function as effectively and permanently as possible, regenerating its cells and helping them function normally. Two drugs, Essentiale and Phosphogliv, are drugs included in this group of drugs. In terms of popularity, both are leaders in the liver medicine market - they are included in the list of drugs prescribed by doctors even more often than other drugs. Let's look at the main characteristics of the drugs in a special table.
Table of parameters related to hepatoprotective medications – Essentiale and Phosphogliv
| Options | Essentiale | Phosphogliv |
| Medication group | Hepatoprotector | |
| Form of production | Capsules, injection solutions. | |
| Main effective substances in the composition | Essential phospholipids purified from soybeans | Phospholipids from licorice (500 mg), glycyrrhizic acid (65 mg). |
| Indications for use |
|
|
| Contraindications |
|
|
| Side effects such as overdoses and errors in taking medications. |
|
|
| Safety for the whole body | Safely | Possible hormonal imbalances |
| Prevention of liver diseases | As prescribed by a doctor | |
| Course of therapy | ||
| An analogue of the drug, with a stronger effect. | “Essentiale Forte N”, “Esliver Forte”, “Rezalut Pro”, “Lipoid S100”, “Hepatomax”. | "Phosphogliv Forte" |
| Manufacturer | Germany | Russia |
| Average price |
|
|
Since liver imbalance directly affects the condition of a person’s skin, such medications can also be prescribed for skin disorders. Liver malfunctions associated with excess cholesterol can also be normalized if such medications are used correctly.
Pay attention! Choline, contained in soybeans, from which the phospholipid complex for Essentiale is extracted, perfectly restores damaged liver cells.
Some differences between the two drugs
When looking for answers to questions such as: “Which is better Phosphogliv or Essentiale Forte?” It is also important to determine the differences between the two drugs. It is worth noting first of all the following differences in the properties, parameters and characteristics of the two drugs for the liver:
- The duration of the therapeutic course varies. It all depends on the stage of the disease, its form, degree of neglect, general condition and special reactions of the patient’s body.
- There are differences in the composition of the auxiliary active components present in both drugs. For example, different concentrations of glycyrrhizic acid, which is extracted from licorice.
- Essentiale is more suitable for pregnant women than Phosphogliv.
- Fofogliv has a greater saturation and concentration of substances in its composition, so it has more side effects.
Pay attention! Glycyrrhizic acid has properties similar to those of some hormones produced by the adrenal glands. Therefore, medications containing such a substance in concentrated doses can easily be confused with hormonal drugs. After all, they greatly influence the dynamics of the levels of certain hormones. Therefore, in large dosages, such hepatoprotectors should be taken with extreme caution, taking into account the doctor’s recommendations, consulting with him about specific hormones and the risk of side effects.
Common features of the two drugs
On general outline You may also have an opinion about which choice is better to make, buy Essentiale for your liver or Phosphogliv is suitable.
- A mixture of phospholipids is part of the main active components of both drugs.
- The form of production is the same.
- The mixture of phospholipids is obtained in the same way - from soybean raw materials. Therefore, the medicines are natural and do not have pronounced chemicals or synthetics.
- Can be used as immunomodulatory agents.
- They protect liver cells from pathogenic destruction and neutralize toxins that have already entered the body.
- They create obstacles to unwanted tissue growth in the liver, which perform a connective function.
- They restore the liver after severe courses of treatment with the strongest antibiotics and cytostatics.
- Reduce inflammatory process for skin disorders.
For example, Essentiale is often prescribed precisely when an increased volume of phospholipids in the drug is required for the treatment of any form of liver disease. But the fact that this drug is suitable for all forms of hepatitis is a 100 percent guarantee.
But Phosphogliv is ideal when you need to stop the development of fibrous formations in the connective tissues of a diseased liver, as well as when a viral form of liver disorder appears.
It is often prescribed for hepatitis C, when it is necessary to obtain a therapeutic result with normalization of the biochemistry of the internal systems of the body. It is generally accepted among doctors that this medication is an enhanced form of the popular Essentiale. Therefore, its prescription to patients is always practiced with greater caution among specialists.
glavvrach.com
Indications for use
First of all, you should consider the indications for taking these drugs.
These hepatoprotectors are among the most popular today. It is these medications that doctors prescribe for the treatment of diseases such as hepatosis, cholestasis, cirrhosis, cystic fibrosis, toxic and infectious liver damage, cholangitis. Also, these medications can be prescribed as maintenance therapy for dermatological problems.
But which drug to choose - Phosphogliv or Essentiale? What is better as an effective immunomodulator that restores liver cells? It all depends on the severity of the patient’s condition and the form of the disease. In any case, it is only within the competence of a doctor to prescribe such a medicine, who will assess the overall picture of health using a series of tests.
Features of the composition
An equally important point is the composition. The main active component of the drugs are phospholipids.
Additionally, the drug "Phosphogliv" includes glycyrrhizic acid. Its chemical structure is almost identical to the natural hormone of the adrenal cortex, which must be taken into account when taking high doses, since side effects can greatly undermine the condition. However, Phosphogliv is no worse than Essentiale, and when taking the recommended doses, the risk of developing serious consequences is minimized. Therefore, it is important that the dosage is determined by the doctor.
In this regard, the drug "Essentiale" is more gentle and safe. This fact is confirmed by relevant clinical studies. From here we can draw a certain conclusion regarding which drug to choose - “Phosphogliv” or “Essentiale”, which is better suited in each specific case.
Practice in children and adults
It is worth noting that the drugs in question are not prescribed to children under 12 years of age. Due to the presence of glycyrrhizated acid in the composition of Phosphogliv, the capsules are prohibited for use during pregnancy. At the same time, the safer medication “Essentiale” is widely used to maintain the condition of pregnant women during periods of severe toxicosis and for other indications that require the participation of hepatoprotectors.
Regimen and dosage
There is an opinion that Phosphogliv is more effective than Essentiale. This can be judged only by the dosage of the active substance in these medications. And here there is also a plus in the direction of the second drug. It should also be noted that this medication contains fewer peroxidation products than capsules such as Phosphogliv. "Essentiale" - our health with minimal negative consequences. And this has been proven by a number of studies during the development and testing of the drug. Essentiale capsules are an excellent option for those patients who vitally need to take phospholipids in high dosages.
Side effects
It should be noted right away that pronounced side effects are indications for dose adjustment or complete discontinuation of the drug. When taking Phosphogliv, the following symptoms may appear:
- allergic reactions: rash, cough, conjunctivitis, difficulty breathing;
- Gastrointestinal disorders: nausea with vomiting, dyspepsia with belching and bloating;
- disorders of the cardiovascular system: edema, increased blood pressure.
The drug "Essentiale" is characterized by such side effects as softening of the stool, abdominal discomfort and allergic reactions due to intolerance to individual components.
Main differences between the drugs
Regarding which drug to choose (“Phosphogliv” or “Essentiale”), which is better suited for the treatment of each individual disease, only a qualified specialist can give an objective assessment. It should be remembered that self-medication is not the best way to help your body cope with the disease; rather, it is a direct way to cause harm. Therefore, consulting a doctor regarding the use of this or that medication is mandatory. All information presented above is for informational purposes only.
However, having considered the main differences between the two popular representatives of the hepatoprotector group of medications, we can highlight the following:
- the drug "Essentiale" is safer and can be used during pregnancy and in large doses;
- hepatoprotector "Phosphogliv" has a greater number of side effects because it has a more saturated composition.
Otherwise, these medications are interchangeable and are analogues in this medicinal group of drugs.
fb.ru
What's the difference?
There are contraindications, consult a specialist
Both medicines classified as hepatoprotectors, that is, they are substances that increase the resistance of liver cells to external damaging influences. Also, these drugs activate the activity of hepatocytes (for example, neutralization of toxins) and promote recovery after their active work and damage to their integrity. What unites these two drugs is the main active ingredient - essential phospholipids, which are able to integrate into the cell membrane of hepatocytes and strengthen it.
Hepatoprotectors are very common in the post-Soviet expanses, but in Europe such therapy is not used so often, which is due to the emphasis of treatment on the cause of the disease rather than on symptomatic therapy.
First of all, we compare the drugs with their main properties and advantages. The word “essential” is translated as fundamental, essential, significant, and therefore we can note their main role in the restoration of liver cells. It is for this reason that drugs based on such active ingredients are the drugs of choice among hepatoprotectors.
Essentiale contains highly purified phospholipids, which are superior in their functional activity to those formed naturally in our body. Eliminates violations of cell membranes, regenerates them and activates disrupted enzymatic processes. As a result, the metabolism of lipids and proteins is normalized and the detoxification capacity of the liver is restored. They release Ess. Forte N in the form of capsules of 300 mg for oral administration (approved for use from 12 years of age) and in the form of a solution for injection Ess. N. The most rational therapy is that begins with the administration of injectable forms with continued treatment with the oral form (in the form of capsules). Injections are administered only intravenously with preliminary dilution with a glucose solution.
Made in Germany.
Phosphogliv Forte is a two-component drug: in addition to 500 mg phospholipids the drug contains 65 mg sodium glycyrrhizinate. Glycyrrhizic acid is obtained from licorice, which has antiallergic, antiviral and immunomodulatory effects. Glycyrate enhances the body's natural protective functions, stimulating the production of interferons and increasing the activity of killer cells, designed to protect all our body systems from foreign formations. It is also available in the form of capsules and lyophilisate for the preparation of a solution for intravenous administration. Contraindicated in pregnant women and during breastfeeding.
Made in Russia.
Conclusion
The cost of the Forte versions of the drugs is approximately the same. The main difference between Phosphogliv and its competitor is the addition of an antiviral component from licorice extract, which can play a major role in the choice between these two hepatoprotective drugs. However, some experts may insist on using a German drug, explaining this by its foreign origin, where the degree of purification of the starting substances and the level of control during production can be much higher than that of domestic manufacturers.