Home » Infectious diseases » Nifuroxazide capsules instructions for use for children. Nifuroxazide syrup: instructions for use, how the drug works and when to take it

Nifuroxazide capsules instructions for use for children. Nifuroxazide syrup: instructions for use, how the drug works and when to take it

Nifuroxazide is such antimicrobial drug, which helps fight various infectious diseases intestines.

The main active substance of the drug is nifuroxazide, used to combat bacteria such as: salmonella, enterobacter, staphylococcus, streptococcus, shigella, E. coli, vibrio cholerae. Nifuroxazide does not kill microorganisms, as antibiotics do, but acts bacteriostatically, without affecting the beneficial intestinal microflora, and therefore does not cause dysbiosis. The advantage of the drug is that it is not absorbed into the blood and is not absorbed in the stomach, but is excreted in the feces.

Use in children

Nifuroxazide is used worldwide to treat intestinal diseases caused by infection in children, including very young children, the drug in the form of a suspension is ideal for small and infant children, and tablets are suitable for older children.

Dosage forms

The drug is available in two versions - tablets and suspension, both forms can be used to treat children. Tablets can be given to children at least 6 years old, and the suspension - from 2 months of age. The tablets are packaged in 24 pieces per package, and the suspension is packaged in 90 ml bottles. The suspension comes with a measuring spoon marked 1 dose, 5 milliliters and half a dose.

Compound

How to use Nifuroxazide

The suspension is used for children at least two months old and adults. The drug is thoroughly shaken before use so that the suspension becomes homogeneous. For dosage, be sure to use a measuring spoon. The amount of medicine varies depending on age:

Children 2-6 months - 2.5 ml (half a spoon) or 5 ml, twice a day.
Children from 6 months to 6 years - 5 ml three times a day.
Children over 6 years of age and adults - 5 ml 4 times a day.

The course of treatment lasts from 5 to 7 days.

It is advisable to take the suspension at regular intervals and independently before or after meals. The suspension can only be taken orally.

The tablets can be used for children and adults from 6 years of age.

Children from 6 years old - 0.2 g or 2 pieces three to four times a day.
Children over 15 years old and adults - 0.2 g or 2 pieces four times a day.

Dose of medication per day - no more than 0.8 g. The tablets are taken regardless of food.

The duration of treatment should not exceed seven days.

If, after a course of treatment with the drug in the form of a suspension or tablets, the signs of the disease do not disappear, you should consult a doctor as soon as possible.

Contraindications

Nifuroxazide should not be used in the following cases:

Intolerance or sensitivity to the active substance or additional components.
Diabetes or a disorder in the breakdown of sucrose.
Allergy to 5-nitrofuran derivatives.
Use in pregnant women is possible only under the supervision of a doctor.
The suspension is not given to children under two months of age, and the tablets are not given to children under six years of age.
The simultaneous use of products containing alcohol is prohibited.
It is not recommended to use it together with sorbents (as they reduce the effectiveness of the medicine).

Adverse reactions

Adverse reactions from taking Nifuroxazide occur very rarely and do not require discontinuation of treatment with the drug, these include:

Increased diarrhea.
Abdominal pain.
Nausea.
Skin reactions: itching and rashes.
Dyspnea.

To minimize side effects and achieve a therapeutic effect, several rules should be followed during treatment:

It is necessary to strictly follow the instructions and doses of the drug.
When treating diarrhea, it is necessary to use rehydration drugs (drugs against dehydration), and you also need to drink a lot of water.
Treatment of diarrhea should be accompanied by a diet, excluding irritating and heavy foods, as well as fresh vegetables and fruits.

Cost of the drug

Packaging of tablets costs minimally - 128 rubles.

Nifuroxazide suspension is sold in Russia under the name Enterofuril and its minimum cost for a 90 ml bottle is 322 rubles.

Natalya is 30 years old. I learned from a friend that Nifuroxazide should be given to children against diarrhea. My 5 year old daughter experiences such problems only when we go on vacation at the seaside. The suspension always helps, 3-4 days of use - and no diarrhea or abdominal pain.
Ekaterina 26 years old. One day, the child was seriously poisoned; he had not only diarrhea, but also a fever. The pharmacy recommended Nifuroxazide tablets (for an 8-year-old child), on the first day of treatment the temperature returned to normal, and within 4 days the patient was completely cured. In addition to the tablets, we drank Enterosgel and a lot of water. Nifuroxazide is not an antibiotic, and it is not scary to give it to a child.
Christina, 35 years old. Despite good reviews, Nifuroxazide was not suitable for my daughter, I bought it in the form of a suspension or syrup for rotavirus. After use, the child vomited every time, sometimes Nifuroxazide gives such adverse reactions. After two days of treatment I had to give it up, although it tastes good and is easy for children to drink. I had to be treated with another drug.

Due to the characteristics of the growing child's body, babies are more susceptible to various intestinal infections, because they do not yet have a developed protective system. For therapy, Nifuroxazide is used - a drug that fights the cause of the disease - various pathogenic microorganisms.

The drug is available in two forms: tablets and syrup. Latest form in the best possible way suitable for the treatment of intestinal infections in children, even the youngest ages. Nifuroxazide can only be used as prescribed by a pediatrician.

Nifuroxazide syrup has a pleasant taste

Any child suffering in acute or chronic form caused by certain infectious agents can be helped to cope with the disease with the help of Nifuroxazide.

This antidiarrheal drug, which is based on a nitrofuran derivative, fights various gastrointestinal bacteria, including:

shigella
enterobacter
salmonella

These bacteria are both gram-positive and gram-negative. Classification is used to distinguish bacteria depending on the structure of their shell. Gram-negative bacteria have stronger protection and immune system it is more difficult for a child to deal with them.

It should be noted that despite its antibacterial activity, the product does not have a negative effect on the state of normal bacterial flora. Indications for the use of the drug are the following factors:

caused by an infectious disease
infectious chronic colitis And
prevention of possible infectious diseases Gastrointestinal tract after surgery
complex therapy of intestinal dysbiosis

Nifuroxazide is used to treat various infectious diseases caused by both gram-positive and gram-negative pathogens.

Action of Nifuroxazide

Nifuroxazide syrup - in the treatment of intestinal infections

The product is active against most types of pathogenic microorganisms that cause infectious diseases. The activity of Nifuroxazide even affects strains of infections that are resistant to other antimicrobial drugs.

It is assumed that the action of the drug is based on inhibition of the activity of dehydrogenases, as well as on disruption of protein synthesis in infectious pathogens. Depending on the dose used, the drug has different effects on pathogenic bacteria.

When used in medium doses, the product has a bacteriostatic effect, as a result of which the growth and reproduction of microorganisms slows down. More high doses products destroy pathogenic bacteria.

Therapeutic doses of Nifuroxazide remain in balance normal microflora intestines, and also do not allow pathogenic microorganisms develop resistance to other antibacterial agents, which allows the drug to be used in combination with systemic agents to combat generalized infections.

The drug is taken orally, with virtually no absorption of its components by the body. A particularly high concentration of the active substance is observed. Such features of the pharmacokinetics of the drug allow Nifuroxazide to exhibit an exclusively enteral antibacterial effect, not have toxic effects and be excreted from the body along with feces.

The drug is considered safe for children and exhibits side effects only in rare cases. The result of a side effect of the drug may be diarrhea. If any of these signs appear, you should consult a doctor.

Nifuroxazide, depending on the dose, has a bacteriostatic or bactericidal effect. The drug is considered safe, but if any side effects occur, you should inform your doctor.

Instructions for use of Nifuroxazide

You cannot take Nifuroxazide syrup without a doctor's prescription!

Nifuroxazide is also available in tablet form. The liquid form of the drug is a suspension, which is also mistakenly called syrup. Before giving the suspension to a child, the container with the product should be thoroughly shaken, since the drug becomes heterogeneous after some time. Depending on the age of the child, the drug is prescribed in different doses and with different frequency of administration:

babies from two months to six months should be given the drug twice a day, in an amount of 110 to 220 milligrams (about half and a whole teaspoon, respectively)
Children from six months to six years old should be given the drug three times a day in a volume of 220 milligrams per dose

The remedy can be given at any time convenient time: Regardless of the time of administration, the drug acts the same. Therapy lasts for five to seven days. If the child feels better long before the end of the course, the doctor should be informed about this. If the baby begins to suffer from the following symptoms, then you need to contact a specialist as quickly as possible:

changes in baby's stool
symptoms of dehydration
sudden increase in temperature

When using the drug, especially if we're talking about about a very young child, many parents may experience certain difficulties. In order to simplify this process somewhat, there are useful recommendations:

When giving the baby the remedy, you should make sure that the child is in a sitting or semi-lying position, in which his body is at an angle of forty-five degrees to the plane of the surface on which he is sitting. Thus, the likelihood that the baby will choke on the suspension taken is significantly reduced.
the spoon with the product should be placed closer to the corner of the lips, and not in the middle oral cavity. If the spoon is placed directly in the center, then the likelihood that the child will push out the spoon with the drug or choke on it increases.
You should not lie to your child that the medicine he is taking is some kind of treat. If the baby does not like the taste of the drug, then in the future he will trust the adults who deceived him less and it will become even more difficult to give him the medicine. When communicating with your baby, you should show calm and perseverance, and then everything will definitely work out.

Nifuroxazide suspension is used only as prescribed by the attending physician. The dosage and frequency of taking the drug depend on the age of the child.

Nifuroxazide - antibacterial agent, produced in the form of a suspension and. The suspension is excellent for children from two months who suffer from infectious diseases. The drug can only be prescribed by a doctor. If any side effects occur, you should stop taking the drug and report any signs to your doctor as soon as possible.

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Enterofuril: suspension for children suffering from infectious…

Registration number:

Trade name: NIFUROXAZIDE

International generic name : Nifuroxazide

Chemical name: N-(5-nitrofurfurylidene)-4-hydrazide p-hydroxybenzoic acid

Dosage form: film-coated tablets

Description: film-coated tablets yellow, round, biconvex

Compound: 1 film-coated tablet contains
Active substances: 100 mg nifuroxazide;
Excipients: colloidal silicon dioxide (Aerosil hydrophilic 200), potato starch, gelatin, talc, magnesium stearate.
Tablet shell: hypromelose, titanium dioxide, talc, polyethylene glycol 20,000, quinoline yellow dye.

Pharmacotherapeutic group: antimicrobial agent - nitrofuran

ATX: A07AX03

Pharmacological action
Pharmacodynamics
Nifuroxazide is a nitrofuran derivative that has an antibacterial effect against gastrointestinal gram-positive bacteria (staphylococci and streptococci) and some gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli). Does not affect the composition of the normal bacterial flora of the large intestine. The detailed mechanism of action of the drug is unknown.
Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacterial cells. It does not cause the emergence of drug-resistant strains, and cross-resistance with other antibacterial drugs has not been observed. The effectiveness of nifuroxazide does not depend either on the pH existing in the intestinal lumen or on the sensitivity of microorganisms to antibacterial drugs. The drug is practically not absorbed from digestive tract, acts exclusively in the intestinal lumen.
Pharmacokinetics
Nifuroxazide is sparingly soluble. After oral administration, it is practically not absorbed from the digestive tract and has no systemic effect. Excreted through the intestines.

Indications for use
Spicy and chronic diarrhea, caused by intestinal gram-positive bacteria (Staphylococcs spp., Streptococcus spp., Haemophylus influenzae), as well as some gram-negative bacteria (Salmonella, Shigella, Klebsiella, Escherichia coli, Proteus spp., Enterobacter spp.).

Contraindications
Allergic reactions to 5-nitrofuran derivatives, children under 6 years of age.

Use during pregnancy and lactation
Use with caution during pregnancy and lactation.

Directions for use and doses
Inside. Adults and children over 6 years of age: 2 tablets (200 mg) 4 times a day every 6 hours. The course of treatment is 6 days. Before use, you should consult your doctor.

Side effect
Nifuroxazide is well tolerated side effects were practically not observed. In isolated cases, in the presence of increased individual sensitivity to nifuroxazide, abdominal pain, nausea and increased diarrhea are possible ( indicated symptoms do not require special treatment or discontinuation of the drug).

Overdose
Signs of a drug overdose are not described.
In case of overdose, gastric lavage and symptomatic treatment are recommended.

Interaction with others medicines
Since nifuroxazide is not absorbed from the digestive tract, the possibility of interaction with other drugs is unlikely.

Special instructions
During treatment, it is necessary to replenish fluid loss orally or parenterally, depending on the patient’s condition.
Use alcoholic drinks during treatment with nifuroxazide may cause a disulfiram-like reaction.

Impact on the ability to drive vehicles and operate machinery.
The drug does not affect the ability to drive a car or operate other mechanisms.

Release form
Film-coated tablets 100 mg.
24 tablets per blister made of Al/PVC.
One blister with instructions for use per cardboard box.

Storage conditions
In a dry place, protected from light, at a temperature of 15 to 25°C. Keep out of the reach of children!

Best before date
4 years.
Do not use after the expiration date stated on the packaging.

Conditions for dispensing from pharmacies
According to the recipe.

Manufacturer/Organization accepting complaints:
Grodzi pharmaceutical plant "Polfa" s.r.o.
Address: 05-825, Grodzisk Mazowiecki, ul. ks. Yu. Poniatowski, 5, Poland.

Nifuroxazide – antibacterial drug, the main purpose is the treatment of intestinal infections that occur with diarrhea (diarrhea). The country of origin is Poland (Polfa company), in Germany (Gedeon Richter) and in Russia.

Many patients often ask the question: is nifuroxazide an antibiotic or not?

We can answer with confidence, no, nifuroxazide is not an antibiotic, although it has a very good antibacterial effect on the human body. This drug is from the nitrofuran group, sometimes mistakenly called “intestinal antibiotic” by the people. This medication differs from antibiotics in that it does not have a detrimental effect on the human intestinal microflora; It is almost not absorbed from the digestive tract into the blood and is not distributed throughout the body through blood sweat. It directly combats pathogenic harmful bacteria that have somehow entered the intestines.

Release form and composition

Nifuroxazide tablets coated, light yellow in color, with a sweet taste and banana smell. The active element of the drug nifuroxazide, which helps with diarrhea, is the substance of the same name. Its content in 1 tablet is 100 mg.
What's up excipients tablets include: gelatin, potato starch, talc, polyethylene glycol, hypromellose, Ti dioxide, Mg stearate, Si dioxide, quinoline yellow.
Nifuroxazide – suspension 4% for oral administration
Available in the form of a suspension (sometimes called a syrup or solution) of 125 ml in a bottle, in a cardboard package. The bottle comes with a measuring spoon. Before using internally, the suspension must be shaken so that there is no sediment at the bottom of the bottle. The active element of the drug nifuroxazide, which helps with diarrhea, is the substance of the same name. Its content in 5 ml suspension is 220 mg.
Additional substances of the suspension are: citric acid monohydrate, Na hydroxide, simethicone, sucrose, methylparaben, carbomer, prepared water, banana essence.

Indications for use, dosage

Nifuroxazide is prescribed when diarrhea occurs to treat it in cases where the infection is sensitive to the drug; in complex therapy for the occurrence of colitis, as well as enterocolitis; in case of dysbacteriosis, as well as for the prevention of infections in cases of abdominal operations.
The drug in tablet form is prescribed to adult patients and children over 6 years of age in accordance with the instructions of the attending physician and the instructions for use. As a rule, daily norm The dose is 4 times a day, 2 tablets every 6 hours. Nuforaxazide can be used regardless of meals, the treatment time is from 5 to 7 days.

The suspension is intended mainly for patients in the age group from 2 months to 6 years for oral use.

Nuforaxazide - instructions for use

Niforaxazide - suspension (syrup or solution) for adults
The drug is taken orally with a small amount of water. Before use, shake the bottle thoroughly until a homogeneous suspension is obtained. For adults, according to the instructions, one measuring spoon of 5 ml four times a day. One 2.5 ml scoop contains 110 mg of nifuroxazide. One 5 ml scoop contains 220 mg of nifuroxazide.

Nifuroxazide instructions for use for children
In pediatrics, nifuroxazide is very often used and is one of the most popular medicines for the treatment of intestinal diseases. A very big advantage is the fact that nifuroxazide does not destroy the intestinal microflora and, as a result, does not cause the development of dysbiosis.

The second positive action is – rapid action of the drug: the therapeutic effect appears within the first few hours after taking the medicine. And it’s also impossible not to notice the presence of a child-friendly dosage form(suspensions, syrup) with a pleasant taste.

Dosage for use for children

Children from 2 months to 6 months: 1-2 scoops per 2.5 ml 2 times a day;
Children from 6 months to 6 years: 1 measuring spoon per 5 ml 3 times a day;
Children over 6 years old: 1 measuring spoon per 5 ml 4 times a day;

Niforaxazide tablets for use in adults and children

Adults and children over 6 years of age are prescribed 2 tablets (200 mg) 4 times a day every 6 hours. The course of treatment is 6 days. Before use, you should consult your doctor.

Niforaxazide during pregnancy
During pregnancy, the drug can be used only according to strict indications and under the supervision of a doctor.
Interaction with other drugs
The drug has high adsorption properties, which should be taken into account when taken simultaneously with other drugs.
Interaction with systemic drugs impossible, due to the fact that the drug is found in the blood only in trace concentrations.

Overdose

Cases of overdose are unknown. If a significant excess of the therapeutic dose of Nifuroxazide occurs, gastric lavage is necessary.

Special instructions

During treatment with nifuroxazide, the consumption of alcoholic beverages is contraindicated, because alcohol increases the body's sensitivity to the drug and can provoke a disulfiram-like reaction (exacerbation of diarrhea, vomiting, abdominal pain, skin flushing, a feeling of heat on the face and upper body, noise in the head, difficulty breathing, tachycardia, a feeling of fear). The drug is not prescribed as monotherapy for the treatment of intestinal infections complicated by septicemia.
If you have symptoms of dehydration In combination with treatment, it is necessary to carry out rehydration therapy (for adults - about 2 liters of fluid per day). During treatment, you should adhere to a certain diet: do not consume raw fruits and vegetables, juices, spicy and fatty foods. Before prescribing the suspension to infants, it is necessary to exclude congenital deficiency of enzymes that break down sucrose.

Nifuroxazide - analogues

A short list of analogues, some of which can be found cheaper, medical product Nifuroxazide and their prices:
Adisord price from - 282 rub.
Stopdiar - 277 rub.
Ecofuril - 240 rub.
Elufor - 308 rub.
Ersefuril - 458 rub.
Polysorb - 33 rub.
This list is not all analogues of this drug.

Nifuroxazide - reviews

Many people have already used this drug and many more are planning to. According to this, there are many reviews online, from bad to very good. Below I will list some of them. And don’t forget to leave your review about this drug, if you have already used it or are planning to use it.

Elizabeth
Advantages: Fast action, convenient release form - tablets for adults and syrup for children.
Disadvantages: none found;
It so happened that my three-year-old son was poisoned. The poor man vomited all night, and in the morning severe diarrhea began. In such cases, we always use Enterosgel at home - it is a wonderful medicine and works very quickly.

Marina
Good remedy from diarrhea. There is an analogue of Stopdiar, but I buy domestic nifuroxazide in capsules and the result is the same. It's great, the diarrhea goes away instantly. True, if it is caused by antibiotics, then bifidokefir helps more, but these capsules are useless. Previously, there was furazolidone, which was also cheap and did a great job with diarrhea after bad food, now there is nifuro, which is also good.

Mitya Kachochkin
I had a little diarrhea, well, about five times a day with a yellow liquid that was abundant and terribly smelly. The doctor prescribed nifuroxazide. After taking it twice a day, the diarrhea got incredibly worse, and before I had time to wipe myself and move away from the toilet, I had to run to the potty again. Several times I didn’t even have time and my pants got dirty. Wow! But the worst thing is that the diarrhea turned bright green, like vitriol, and the stench intensified once again, even the upstairs neighbors swore that it stank...
From admina: I can’t publish the full review, but I laughed incredibly :)

Each capsule contains:

active substance: nifuroxazide - 100 mg or 200 mg;

excipients: sucrose, magnesium stearate, modified corn starch (Starch 1500).

Composition of the gelatin capsule shell:

Gelatin, titanium dioxide E171, quinoline yellow E104, azorubine E122, crimson 4R E124, purified water.

Description

100 mg capsules:

Hard gelatin capsules No. 1 are cylindrical in shape with hemispherical ends of yellow color.

200 mg capsules:

Hard gelatin capsules No. 0 are cylindrical in shape with hemispherical ends of yellow color.

Indications for use

Treatment of acute diarrhea of bacterial origin in the absence of signs of infection (for example, worsening general condition, fever, toxic infection, etc.) in addition to rehydration therapy.

The dose and type of rehydration (orally or intravenously) is determined depending on the severity of diarrhea, age, condition of the patient, and the presence of concomitant diseases.

Contraindications

Allergic reactions to 5-nitrofuran derivatives;

Hypersensitivity to any of the components of the drug;

Fructose intolerance, glucose-galactose malabsorption syndrome, or sucrase and isomaltase deficiency (due to the presence of sucrose in the drug).

Pregnancy;

Children's age up to 6 years.

Pregnancy and lactation

Use of nifuroxazide during pregnancy:

There are no clinical data regarding the use of nifuroxazide during pregnancy. Animal studies show no direct or indirect effect on pregnancy, embryonic or fetal development, labor or child development after birth.

During pregnancy, nifuroxazide is contraindicated.

Use of nifuroxazide during breastfeeding:

Due to the lack of sufficient clinical data, caution should be exercised when prescribing nifuroxazide to breastfeeding women.

During the lactation period continued breastfeeding in case of a short course of treatment with the drug.

Directions for use and doses

Nifuroxazide - LF is taken orally, regardless of food intake, at regular intervals.

Adults - 800 mg (4 capsules of 200 mg or 8 capsules of 100 mg) per day, divided into 2-4 doses.

Children over 6 years old - 600-800 mg (3-4 capsules of 200 mg or 6-8 capsules of 100 mg) per day, divided into 2-4 doses.

To treat acute diarrhea, the drug must be taken for 3 days. If after this the symptoms of the disease do not disappear, you should consult a doctor.

The duration of taking nifuroxazide should not exceed 7 days.

Side effect

Nifuroxazide is usually well tolerated and exhibits virtually no side effects.

From the hematopoietic and lymphatic system:

One case of granulocytopenia has been described.

From the gastrointestinal tract:

In cases of individual hypersensitivity to nifuroxazide, abdominal pain, nausea and exacerbation of diarrhea may occur. If such symptoms of minor intensity occur, there is no need to use special therapy or discontinue the use of nifuroxazide. If the above symptoms develop to significant intensity, you should stop taking the medication. In the future, the patient should not take nitrofuran derivatives.

From the skin and subcutaneous tissue:

Possible development allergic reactions(skin rash, urticaria, Quincke's edema, anaphylactic reactions).

Overdose

Overdose symptoms are not known. If the dose is exceeded, gastric lavage and symptomatic treatment are recommended.

Interaction with other drugs

When treating with nifuroxazide, simultaneous use of oral medications should be avoided due to the strong adsorption properties of the drug.

Since nifuroxazide does not enter the circulatory system, interactions with systemic drugs are unlikely and are not yet known.

Ethanol intake may cause hypersensitivity symptoms.

Features of application

The drug is not prescribed as monotherapy for the treatment of intestinal infections accompanied by septicemia.

If symptoms of dehydration appear during treatment with the drug, it is necessary, depending on the clinical condition patient, carry out rehydration therapy (adults - about 2 liters of fluid per day).