Aevit instructions for use for men. "Aevit": what is it for and how is it useful

The properties of Aevit are determined pharmacological effects fat-soluble vitamins A and E, which are part of it. The drug acts on the nuclei of cells in target organs and initiates the synthesis of protein-enzymes and structural elements of tissues, stimulates regeneration processes, increases the specific and nonspecific resistance of the body. AEvit normalizes metabolism, has an active antioxidant effect, restores capillary blood circulation, tissue and vascular permeability, and increases tissue resistance to hypoxia.
Aevit is well absorbed from the gastrointestinal tract. Next, vitamins A and E are transported into the lymph, then into the blood plasma, where they bind to specific proteins and are transported to organs and tissues. Excess vitamin A is deposited in the liver, mainly in the form of palmitic acid esters. Vitamin A is excreted with bile into the intestines and participates in enterohepatic circulation. It undergoes biotransformation in the liver, turning first into active metabolites, and then into inactive metabolic products secreted by the kidneys, intestines and exhaled by the lungs. Elimination of vitamin A occurs slowly—in 3 weeks, 34% of the dose taken is eliminated from the body. Excess vitamin E is deposited in tissues, creating a depot in them (especially in the liver), which maintains normal level vitamin E in blood plasma. In the body, vitamin E undergoes biotransformation, turning into a number of metabolites with a quinone structure. Vitamin E is excreted unchanged in bile and in the form of metabolites in urine.

Indications for use of the drug Aevit

Treatment of diseases requiring long-term administration high doses ah of vitamin A in combination with vitamin E: atherosclerotic changes in blood vessels, tissue trophic disorders, obliterating endarteritis, psoriasis, lupus erythematosus, optic nerve atrophy, retinitis pigmentosa.

Use of the drug Aevit

Prescribed to adults with therapeutic purpose inside after meals. Take 1 capsule daily for 30-40 days. If necessary, a second course of therapy is carried out after 3-6 months.

Contraindications to the use of the drug Aevit

Hypersensitivity to the components of the drug, thyrotoxicosis, chronic glomerulonephritis, chronic circulatory failure, pregnancy, children.

Side effects of the drug Aevit

Allergic reactions, dyspeptic disorders such as pain in the epigastric region, nausea, diarrhea. With long-term use of the drug, exacerbation is possible cholelithiasis and chronic pancreatitis. In rare cases, chronic hypervitaminosis A may develop, which manifests itself as lesions nervous system(headache, insomnia, irritability, apathy, paresthesia), changes in the skin (dry and cracked skin on the palms and soles, hair loss, seborrheic rashes), arthralgia, gait disturbance, hepato- and splenomegaly.

Special instructions for the use of the drug Aevit

The drug is used with caution in patients with myocardial infarction, risk of thromboembolism, severe atherosclerosis of the coronary arteries; for acute or chronic nephritis.
Aevit should not be prescribed with other medications that contain vitamins A and its synthetic analogs, due to the risk of developing hypervitaminosis A.

Interactions of the drug Aevit

The drug should not be co-administered with estrogens, which increase the risk of developing hypervitaminosis A; nitrites and cholestyramine, which interfere with the absorption of vitamin A.
Retinol reduces the anti-inflammatory effect of GCS.

Overdose of the drug Aevit, symptoms and treatment

Simultaneous administration of a large amount of the drug is accompanied by a sudden increase in CSF pressure (without pathological changes in the cerebrospinal fluid itself), severe headache, drowsiness, and blurred vision (diplopia). In severe cases develop seizures, heart weakness.

Storage conditions for the drug Aevit

In a dry place, protected from light, at a temperature of 15-25 °C.

List of pharmacies where you can buy Aevit:

• Saint Petersburg

In this medical article You can get acquainted with the drug Aevit. The instructions for use will explain in what cases injections and capsules can be taken, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the forms of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Aevit vitamins, from which you can find out whether they helped improve the appearance and health of skin, hair, nails, as well as the general strengthening of the body in adults and children, for which they are also prescribed. The instructions list analogues of Aevit, prices of the drug in pharmacies, as well as its use during pregnancy.

Comprehensive vitamin remedy is Aevit. The instructions for use indicate that vitamins have an antioxidant and immunostimulating effect on the body.

Release form and composition

Pharmacies receive:

• Aevit capsules in bottles, jars or blisters;
• oil solution for intramuscular administration in ampoules of 1 ml (injection form of the drug).

1 capsule contains retinol palmitate 100,000 IU and alpha-tocopherol acetate 0.1 g; V glass jar 25 pcs., or in a blister pack 10 pcs.

Ampoule with 1 ml injection solution contains retinol acetate 0.035 g and alpha-tocopherol acetate 0.1 g; in a cardboard box 10 pcs.

Pharmacological action

The components of the drug Aevit stimulate tissue growth and reproduction of epithelial cells, have a positive effect on lipid and protein metabolism, take part in the processes of tissue regeneration, maintaining the visual and reproductive functions of the body.

The medication significantly normalizes tissue trophism and the permeability of vessel walls, improves capillary blood circulation. The components of the drug are the active components - retinol palmitate and alpha-tocopherol acetate. Alpha tocopherol acetate belongs to the fat-soluble vitamins.

It regulates the body's metabolic processes and has a significant antioxidant effect. Antioxidant action this drug is associated with its ability to reduce the formation of peroxides, slow down the rate of oxidation of unsaturated fatty acids, and prevent the destruction of red blood cells.

Palmitate (vitamin A) is a fat-soluble vitamin that regulates tissue metabolism in the body. It has a general strengthening effect, participates in the formation of the visual signal, and reduces the risk of developing diseases of the mucous membranes of the respiratory and digestive systems.

Why take Aevit (vitamins)?

Indications for use of the drug include:

• hemeralopia ( night blindness);
• abetalipoproteinemia;
• psoriasis;
• keratomalacia;
• peripheral neuropathy;
• systemic lupus erythematosus;
• obliterating endocarditis and endarteritis;
• xerophthalmia;
• necrotizing myopathy;
• optic nerve atrophy;
• retinitis pigmentosa;
• atherosclerosis of the vascular bed;
• regional or systemic disorders of microcirculation and tissue trophism.

What else is it prescribed for? Indications for use also include pathological conditions, when the intake of vitamins A and E from food is significantly reduced, which makes it possible to use Aevit in the treatment of the following nosological units:

• unbalanced or inadequate nutrition;
• liver cirrhosis and pathologies that impede the physiological flow of bile into the lumen of the digestive tube;
• acute and chronic infectious diseases;
• idiopathic weight loss;
• diseases small intestine of various origins (celiac disease, Crohn's disease, malabsorption syndrome, and so on);
• chronic stress;
• steatorrhea;
• drug addiction, alcoholism and nicotine addiction;
• chronic diarrhea;
• cystic fibrosis of the pancreas;
• gastrectomy.

Instructions for use

AEvit capsules are taken orally, regardless of food intake, 1 tablet per day. Injections in ampoules - intramuscularly at a dose of 1 ml per day. Duration of treatment is 20-40 days at intervals of 3-6 months. Repeated courses are possible.

There is also an indication for the use of a vitamin preparation as an external agent for lubricating the nail plates in order to strengthen and prevent brittle nails.

Contraindications

Myocardial infarction, risk of thromboembolism, severe atherosclerosis of the coronary arteries, acute and chronic inflammation of the kidneys (prescribed, but with great caution). Individual intolerance to the vitamins contained in Aevita.

Thyrotoxicosis, chronic glomerulonephritis, and chronic circulatory failure. According to the instructions, taking Aevita during pregnancy and lactation is allowed only with the permission of a doctor.

Side effects

The use of Aevit vitamins, as a rule, is well tolerated by patients, because the active components of the pharmaceutical drug are part of the physiological metabolism of the human body and are required for normal development. In isolated cases, side effects may occur in the form of one of the following adverse effects:

Children, pregnancy and breastfeeding

Prescribe with caution during pregnancy (especially in the 1st trimester) and during lactation. Contraindicated for children under 14 years of age.

Special instructions

Drug interactions

Retinol increases the risk of developing hypercalcemia. When taken simultaneously with cholestyramine, colestipol, mineral oils, neomycin, the absorption of vitamins A and E decreases. An increase in their dose is required.

Oral contraceptives increase plasma concentrations of retinol. Reception during treatment with tetracycline increases the risk of intracranial hypertension. Vitamin E enhances the effect of corticosteroids, NSAIDs, antioxidants and reduces the effect and toxicity of vitamins A, D, cardiac glycosides.

High doses of vitamin E cause vitamin A deficiency. Vitamin E increases the effectiveness of antiepileptic drugs. In combination with anticoagulants, vitamin E increases the risk of hypoprothrombinemia and bleeding. Iron supplements enhance the oxidative process and increase the need for vitamin E.

Vitamin analogues AEvit

Analogs are determined by structure:

1. AEcaps.
2. VitAE.

Storage conditions and periods

Must be stored in a dry place, protected from light, out of reach of children, at room temperature. The shelf life of capsules is 2 years, solution for intramuscular administration is 3 years. Dispensed without a prescription

Price in pharmacies

The average price of Aevit (capsules No. 30) in Moscow is 106 rubles. In Kyiv you can buy medicine for 15 hryvnia, in Kazakhstan - for 150 tenge. In Minsk, pharmacies offer the drug for 0.88 BYN. ruble Sold according to prescription.

Aevit is a complex of vitamins A+E, which has an antioxidant and immunostimulating effect on the body.

The components of the drug stimulate the growth and restoration of epithelial cells, have a positive effect on lipid and protein metabolism, take part in the processes of tissue regeneration, maintaining the visual and reproductive functions of the body.

Aevit vitamins significantly normalize tissue trophism and the permeability of vascular walls, and improve capillary blood circulation.

Vitamin E has an antioxidant effect - it inhibits the development of reactions involving free radicals, prevents the formation of peroxides that damage cellular and subcellular membranes.

Without vitamin E, it is extremely difficult for the body to maintain normal muscle and nervous activity. In combination with selenium, it inhibits the oxidation of unsaturated fatty acids, prevents hemolysis of electrolytes.

Vitamin A is fat-soluble; it regulates tissue metabolism in the body. It has a general strengthening effect, participates in the formation of the visual signal, and reduces the risk of developing diseases of the mucous membranes of the respiratory and digestive systems.

Without vitamin A, the skin ages quickly, since it is necessary for the division and life of epithelial cells.

Composition of Aevit - 1 capsule contains retinol palmitate (vitamin A) - 0.055 g (100,000 IU), a-tocopherol acetate (vitamin E) - 0.1 g.

Indications for use

Why is Aevit taken? According to the instructions, vitamins are prescribed in the following cases:

• psoriasis, lupus erythematosus;
• atherosclerotic vascular damage, impaired microcirculation and tissue trophism, obliterating endarteritis;
• optic atrophy, night blindness, retinitis pigmentosa, xerophthalmia and keratomalacia

Aevit vitamins are necessary for people with a reduced intake of vitamins A and E from food, due to dietary restrictions or reduced absorption of substances by the digestive system. It's about about diseases such as:

• diarrhea;
• gastrectomy;
• steatorrhea (failure in the absorption of fats in the gastrointestinal tract and their increased excretion in feces);
• liver cirrhosis, chronic cholestasis, bile duct obstruction, obstructive jaundice;
• acute and chronic infectious diseases;
• celiac disease, malabsorption syndrome, Crohn's disease;
• cystic fibrosis of the pancreas;
• drug addiction, nicotine and alcohol addiction;
• rapid weight loss, inadequate and unbalanced nutrition;
• hyperthyroidism;
• prolonged stress, taking medications, in particular neomycin, colestipol, cholestyramine, mineral oils and products containing iron.

In some cases, additional use of vitamins is indicated for people suffering from abetalipoproteinemia, necrotizing myopathy and peripheral neuropathy.

Instructions for use Aevit, dosage

Capsules are taken orally after meals with clean water.

The standard dosage of Aevit vitamins according to the instructions is 1 capsule per day daily. The course of treatment is 20-40 days.

After a break of 3-6 months, the course can be repeated.

Ampoules Aevit

Vitamins in ampoules are used for intramuscular injections. Aevit is prescribed 1 ml once a day, for a course of 20 days. Before injection, the ampoule must be warmed to body temperature.

For endarteritis and trophic disorders, the course of vitamins lasts 30-40 days. After a 4-6 month break, it can be repeated.

Side effects

The instruction warns about the possibility of developing the following side effects when prescribing Aevit vitamins:

• Allergic reactions to components (including skin rash), pain in the epigastric region, dyspeptic disorders (nausea, vomiting, diarrhea).
• At long-term use in large doses, exacerbation of cholelithiasis and chronic pancreatitis is possible.
• Local reactions with intramuscular injection - pain, infiltration, soft tissue calcification.

Contraindications

It is contraindicated to prescribe Aevit in the following cases:

• increased sensitivity to the active components of the vitamin complex;
• thyrotoxicosis;
• chronic glomerulonephritis;
• chronic circulatory failure.

With caution under medical supervision:

myocardial infarction;

• thromboembolism or the risk of its development;
• severe forms of atherosclerosis of the coronary arteries;
• acute and chronic inflammatory diseases of the kidneys of a nonspecific nature.

Overdose

Simultaneous intake of a large amount of Aevit is accompanied by a sudden increase in blood pressure cerebrospinal fluid(without pathological changes in the cerebrospinal fluid), severe headache, drowsiness, visual impairment (diplopia). In severe cases, convulsive seizures and cardiac weakness develop.

With long-term use, chronic hypervitaminosis A may develop, which is manifested by damage to the central nervous system (headache, insomnia, irritability, apathy, paresthesia), changes in the skin (dry and cracked skin on the palms and soles, hair loss, seborrheic rashes), pain in bones, gait disorders, enlarged liver and spleen.

If signs of overdose appear, the drug should be discontinued. Treatment is symptomatic.

Analogues of Aevit, price in pharmacies

If necessary, you can replace Aevit vitamins with an analogue of the active substance - these are the following drugs:

1. VitAE,
2. AEcaps.

By ATX code:

• Multi-tabs Baby,
• Pregnavit F.

When choosing analogues, it is important to understand that the instructions for use of Aevit, price and reviews do not apply to drugs with similar effects. It is important to consult a doctor and not change the drug yourself.

Price in Russian pharmacies: Aevit capsules 200 mg. 10 pcs. – from 30 to 37 rubles, 20 capsules – from 33 to 60 rubles, according to 792 pharmacies.

Store in a dry place, protected from light, out of reach of children at room temperature. The shelf life of capsules is 2 years, solution for intramuscular administration is 3 years.

Drug interactions

The drug is not prescribed simultaneously with other medicines, containing vitamin A, as well as its synthetic analogues.

When the drug is used simultaneously with estrogens, there is an increased risk of developing hypervitaminosis A, so prescribing Aevit to patients taking estrogens is undesirable.

Nitrates and cholestyramine, when used simultaneously with Aevit vitamins, interfere with the absorption of retinol palmitate.

Retinol palmitate, when used in combination with glucocorticosteroids, reduces their anti-inflammatory effect.

ABOUT beneficial influence Vitamins A and E affect the body a lot, so Aevit is in demand among adults, especially for skin problems. But is it possible to give such medicine to a child and how to take Aevit correctly?

Release form

Aevit is available in soft capsules, which are packaged 10, 20, 30 or 50 in one pack. Another form of the medicine is 1 ml ampoules for injection, but this Aevit is used less frequently.

Compound

Each Aevit capsule contains the following two active compounds:

1. Retinol palmitate. This is a form of vitamin A that comes in a dosage of 100,000 IU per capsule.
2. Alpha tocopherol acetate. Each capsule contains 0.1 g of this form of vitamin E.

They are supplemented with soybean, sunflower or corn oil, and the capsules themselves are made of glycerol, gelatin and dyes.

You can learn about the benefits of vitamin A for human organism from the program of E. Malysheva:

Operating principle

The action of Aevit is ensured by its main components:

• Vitamin A required for sharp vision, active growth, strengthening bone tissue and healing of skin damage. Without a sufficient amount of it in the body, the immune system and the condition of the mucous membranes suffer.
• Vitamin E important for preventing inflammatory processes, work of endocrine organs and heart, blood clotting, immune system and maintaining the structure of vascular walls. In addition, this substance affects tissue regeneration and improves the absorption of retinol.

When taking Aevita, the condition of vision, blood vessels and skin structure improves. The medicine helps restore blood circulation in the capillaries, normalize tissue permeability and make them more resistant to hypoxia.

You can learn more about vitamin E from the video below:

Indications

Often, for vision problems, the baby is prescribed Aevit

At what age is it allowed to take it?

Instructions for use of Aevita include contraindications for children under 14 years of age. This is due to the fact that the dosage of vitamins in such a medicine is much higher than the norm for children. For example, a child aged 2 years needs only 1350 IU of retinol per day, at 4-5 years old - 1600 IU of this compound, at 7 years old - 2300 IU, and at 11 years old - 3000 IU. If we compare it with the amount of retinol in one Aevita capsule (100 thousand IU), it becomes clear that such a medicine threatens to overdose on vitamin A.

As for the second component, a one-year-old child needs vitamin E in a daily amount of 6 mg, and at 3 or 6 years old its daily intake should be only 7 mg. If children are already 11 years old, they need 8-10 mg of tocopherol every day. And since each Aevit capsule contains such a vitamin in a dose of 100 mg, it is immediately clear that this medicine is not suitable for small children.

Even if a child is deficient in vitamins E and A, and this deficiency is dangerous for his health, it is still unacceptable to give Aevit to children without a doctor’s prescription. The medicine can be used in childhood only for external treatment, for example, lubricating the burn site with the contents of the capsule for more fast healing skin.

A child’s intake of any vitamins must be agreed upon with a pediatrician.

Contraindications

Aevit should not be used to prevent a lack of vitamin A or tocopherol, because the dosage of such compounds in this drug is increased (it is considered not preventive, but therapeutic). Aevit should also not be prescribed for:

• Allergies to any of the components of the medicine. If you have an intolerance to retinol or vitamin E, the drug may be dangerous (may cause immediate reaction organism).
• Thyrotoxicosis. Due to the high dosage of tocopherol, hormone metabolism in thyroid gland may be violated.
• Hypervitaminosis A. Taking Aevit in such a situation will only aggravate the problem.
• Glomerulonephritis or renal failure. The disease worsens due to excess intake of vitamin E. Also, allergies, which Aevit can provoke, are very dangerous for kidney function.
• Cholecystitis. The medicine can thicken bile, which only worsens this disease.
• Viral hepatitis. With this disease, Aevit will have a toxic effect on the liver.
• Reduced level of prothrombin in the blood. This condition threatens thrombosis, which can also lead to thrombophlebitis or, which is especially dangerous, to the detachment of a blood clot and subsequent vascular embolism.
• Breastfeeding a baby. High dosages of vitamins from Aevit will reach the baby through breast milk.
• First trimester of pregnancy. It is advised to plan conception no earlier than 6 months after the end of treatment with Aevit.

Side effects

Taking Aevita can cause skin rashes and other allergic reactions, as well as dyspepsia and abdominal pain. If you take the medicine for too long, chronic pathologies such as pancreatitis and cholelithiasis worsen. In addition, long-term use of Aevita can cause pain in the bones of the legs and hair loss.

Instructions for use and dosage

Children over 14 years of age are given Aevit 1 capsule per day. There is no need to chew the medicine - the capsule should simply be swallowed with water. Eating does not affect the time it takes to swallow Aevit.

The duration of taking Aevita should be determined by a doctor, but often the capsules are taken for quite a long time (up to 40 days). If it is necessary to undergo a second course of treatment, the drug is prescribed after a 3-6 month break.

Aevit should be taken once a day without chewing the capsule.

Overdose

The use of Aevit in children under 14 years of age may result in the following symptoms of overdose:

• Vomit.
• Fever bodies.
• Decreased appetite.
• Increased sweating.
• Dry mouth.
• Drowsy state.
• Skin rash.
• Increased intracranial pressure.
• Headache.
• Nausea.
• Soreness of bones and muscles.
• Peeling of palms and lips.
• Exacerbation of pancreatitis or gallbladder disease.
• Dizziness.
• Blurred vision.
• Stomach ache.
• Nervous excitement.
• Liquefaction of stool.
• The appearance of bleeding.
• Thrombophlebitis.
• Enlarged liver.

If such symptoms occur, you should immediately stop using Aevita and seek medical advice. medical care so that the doctor prescribes symptomatic treatment.

If such symptoms occur, you should immediately stop using Aevit and seek medical help.

Interaction with other drugs

• Taking Aevit affects treatment with calcium preparations, causing an increase in the level of this mineral in the blood.
• Assimilation active substances Aevita worsens when taking neomycin, iron supplements, colestipol, mineral oils or cholestyramine together.
• When prescribed together with Aevit isotretinoin, the risk toxic effects vitamin A increases.
• Retinol from Aevit, prescribed together with tetracyclines, often provokes intracranial hypertension.
• The presence of vitamin E in Aevit will increase the effectiveness of treatment with cardiac glycosides, vitamins D and A, nonsteroidal anti-inflammatory drugs, glucocorticoids, and antiepileptic drugs.
• If Aevit and anticoagulants are used simultaneously, this will increase the risk of bleeding.

Terms of sale

Aevit is available to any customer at a pharmacy without the need to present a prescription. But, despite the over-the-counter sale, you should consult a doctor before purchasing such a drug. The price of 20 capsules of this medicine is about 60 rubles.

Storage conditions and shelf life

Aevit should be kept away from small children and direct sunlight at a temperature of no more than +25°C. The medicine does not need to be used if its expiration date (it is 2 years) has already expired.

Aevit

Compound

1 soft capsule of the drug Aevit contains:
Retinol palmitate (vitamin A) – 100,000 IU;
Alpha tocopherol acetate (vitamin E) – 0.1g;
Excipients.

Pharmacological action

Aevit is a complex vitamin preparation with antioxidant and immunostimulating effects. In addition, the components of the drug take part in various physiological processes in the body, including stimulating the proliferation of epithelial cells and bone growth, participating in tissue regeneration processes, affecting protein and lipid metabolism, and are also necessary to maintain reproductive and visual function. The drug Aevit helps improve capillary blood circulation, normalizes the permeability of the vascular wall and tissue trophism. The drug contains the active components alpha-tocopherol acetate and retinol palmitate. The mechanism of action and therapeutic effects of the drug are based on pharmacological properties active components included in its composition.

Retinol palmitate (vitamin A) is a fat-soluble vitamin that regulates tissue metabolism. The drug takes part in the formation of the visual signal by converting the opsin protein into rhodopsin, a substance necessary for visual adaptation in the dark. Retinol palmitate has a general strengthening effect, enhances myelopoiesis, stimulates the function of macrophages, increases humoral and cellular immunity, reduces the risk of developing diseases of the mucous membranes of the digestive tract and respiratory system. Due to the presence of a large number of unsaturated bonds in the retinol molecule, the drug takes part in various redox reactions in the body, and also plays an important role in the synthesis of glycosaminoglycans, lipids and proteins. Vitamin A takes part in fat metabolism, in particular it is involved in the formation of cholesterol. Retinol palmitate has a beneficial effect on the functioning of the endocrine and exocrine glands, including influencing the function of the lacrimal, sebaceous and sweat glands, and increases the secretion of trypsin and lipase. The drug takes part in the formation of bone tissue and bone growth, and also has a positive effect on reproductive function and is necessary for the normal development of the embryo. Vitamin A has positive influence on the condition of the skin, in particular, retinol palmitate stimulates the proliferation of epithelial cells, rejuvenates the cell population and helps reduce the number of cells following the path of terminal differentiation, and also slows down the processes of keratinization.

The antioxidant effect of the drug is due to the presence of a large number of unsaturated bonds in the retinol molecule, thanks to which it is able to interact with various types free radicals. In addition, retinol palmitate potentiates the antioxidant effect of tocopherol, which in turn prevents the oxidation of retinol and prevents the development of its pro-oxidant properties and prevents the formation of toxic peroxide products.
Alpha tocopherol acetate is a fat-soluble vitamin that has a pronounced antioxidant effect and also regulates metabolic processes in the body. The antioxidant effect of the drug is based on its ability to slow down the oxidation of unsaturated fatty acids, reduce the formation of peroxides and prevent hemolysis of red blood cells. In addition, the protection of cells from the action of peroxide compounds and free radicals is carried out by vitamin E due to the ability of the alpha-tocopherol acetate molecule to integrate into the cell membrane, thus preventing the contact of oxygen and free radicals with unsaturated lipids of cell membranes.
Alpha-tocopherol acetate is a cofactor in various enzyme systems. It has a positive effect on the vascular system, stimulates microcirculation and normalizes tissue trophism by improving capillary circulation, as well as normalizing tissue and capillary permeability. Vitamin E helps increase tissue resistance to hypoxia due to stabilization of the mitochondrial membrane and reduction of oxygen consumption by cells. Mutual potentiation of the actions of vitamin E and ubiquinone was noted. By inhibiting the activity of phospholipase A2 in lysosomes, alpha-tocopherol acetate protects the phospholipid layer of cell membranes from destruction. The drug takes part in the synthesis of nucleic acids, heme, cytochromes and other heme-containing proteins. Vitamin E has an immunostimulating effect, in particular alpha-tocopherol acetate stimulates cellular and humoral immunity, increases the activity of T-lymphocytes. Together with retinol palmitate, alpha-tocopherol acetate takes part in maintaining reproductive function, necessary for normal embryonic development and formation of the reproductive system.

The pharmacokinetics of the drug is based on the pharmacokinetic properties of its components.
Absorption and distribution: retinol palmitate is absorbed into gastrointestinal tract After interaction with bile acids, alpha-tocopherol acetate is slowly absorbed into digestive tract. The bioavailability of alpha-tocopherol acetate is about 50%, the peak plasma concentration of vitamin E is observed 4 hours after oral administration. The components of the drug are evenly distributed in organs and tissues, while excess retinol is deposited in the liver. Alpha-tocopherol acetate is deposited in the liver, muscle and adipose tissue, red blood cells, testes and adrenal glands.
Metabolism: Retinol acetate is metabolized in the liver to form a number of pharmacologically active and inactive metabolites. Alpha-tocopherol acetate is metabolized in the body to form pharmacologically inactive metabolites.
Excretion: retinol is excreted in the form of metabolites in bile and urine. Alpha-tocopherol is excreted primarily in bile and in small amounts in urine, both unchanged and in the form of metabolites. Retinol is excreted from the body slowly; after a single use, 34% of the dose taken is excreted from the body within 3 weeks.

Indications for use

The drug is used to treat patients who require long-term administration of high doses of vitamin A and vitamin E, including the drug is used in the treatment of such diseases:
- atherosclerotic vascular lesions, impaired microcirculation and tissue trophism, obliterating endarteritis;
- lupus erythematosus, psoriasis;
- the drug is also used in ophthalmological practice to treat patients suffering from optic nerve atrophy, hemeralopia (night blindness), xerophthalmia, keratomalacia and retinitis pigmentosa.

The drug is indicated for patients who have a reduced intake of vitamins A and E from food due to dietary restrictions or decreased absorption of vitamins A and E in the digestive tract, including the following conditions:
- gastrectomy;
- diarrhea;
- steatorrhea (impaired absorption of fats in the gastrointestinal tract and their increased excretion in feces);
- celiac disease, Crohn's disease, malabsorption syndrome (including malabsorption syndrome developed against the background of tropical sprue);
- liver cirrhosis, bile duct obstruction, chronic cholestasis, obstructive jaundice;
- cystic fibrosis of the pancreas;
- acute and chronic infectious diseases;
- quick loss weight, unbalanced and inadequate nutrition, including to compensate for the deficiency of vitamins A and E in patients on parenteral nutrition;
- drug addiction, alcoholism, nicotine addiction;
- long-term condition stress, taking medications, including cholestyramine, colestipol, neomycin, mineral oils and preparations containing iron. In addition, the drug is prescribed to patients following a diet with a high content of polyunsaturated fatty acids in food;
- hyperthyroidism.

In addition, the drug can be prescribed to patients suffering from necrotizing myopathy, peripheral neuropathy and abetalipoproteinemia.

Directions for use

The drug is taken orally; it is recommended to swallow the capsule whole, without chewing, with a sufficient amount of water. It is advisable to take the drug after meals.
The duration of the course of treatment and the dose of the drug are determined by the attending physician depending on the nature of the disease and the individual characteristics of the patient.
Adults are usually prescribed 1 capsule of the drug once a day. The duration of treatment is usually 30-40 days. If necessary, it is possible to conduct a second course of therapy with Aevit 3-6 months after the end of the previous course.

Side effects

The drug is usually well tolerated by patients, however, in isolated cases, side effects such as nausea, vomiting, stool disorders, gastralgia and allergic reactions may develop.
In patients taking the drug Aevit for a long time, exacerbation of cholelithiasis and chronic pancreatitis is possible.
With long-term use of the drug, as well as long-term use of the drug in doses exceeding the recommended ones, patients may develop hypervitaminosis A, the symptoms of which are damage to the central and peripheral nervous system (including headache, disturbance of sleep and wakefulness, increased irritability, apathy, paresthesia), as well as dryness and cracks in the skin of the palms and soles, alopecia, seborrhea, joint pain, changes in gait and an increase in the size of the liver and spleen.

Contraindications

Increased individual sensitivity to the components of the drug.
The drug is contraindicated in patients suffering from thyrotoxicosis, chronic glomerulonephritis and chronic failure blood circulation
The drug should be prescribed with caution to patients with myocardial infarction, as well as to patients with an increased risk of thromboembolism.
The drug is prescribed with caution to patients suffering from severe atherosclerosis of the coronary arteries, as well as acute and chronic inflammatory diseases kidney

Pregnancy

During pregnancy, the drug should be taken strictly as prescribed by the attending physician, who, before prescribing the drug, must weigh the expected benefits for the mother and the potential risks for the fetus. It is necessary to prescribe the drug especially carefully in the first trimester of pregnancy, given high content in a vitamin A preparation.
During lactation, the drug is taken strictly as prescribed by the doctor.

Drug interactions

The drug is not prescribed simultaneously with other medications containing vitamin A, as well as its synthetic analogues.
With simultaneous use of the drug with estrogens, there is an increased risk of developing hypervitaminosis A, therefore, the administration of the drug Aevit to patients taking estrogens is undesirable.
Nitrates and cholestyramine, when used simultaneously with the drug Aevit, interfere with the absorption of retinol palmitate.
Retinol palmitate, when used in combination with glucocorticosteroids, reduces their anti-inflammatory effect.

Overdose

When using excessive doses of the drug, patients experience the development of headache, drowsiness and visual impairment, in addition, a sudden increase in cerebrospinal fluid pressure is possible, which is not accompanied by pathological changes in the cerebrospinal fluid itself. With a further increase in dose, seizures and heart failure may develop. With long-term use of excessive doses of the drug, the development of chronic vitamin A intoxication is possible, which is manifested by disorders of the central and peripheral nervous system, skin, musculoskeletal system and endocrine glands.
There is no specific antidote. If symptoms of acute or chronic intoxication with the drug develop, it is necessary to stop taking the drug and, if necessary, carry out symptomatic therapy.

Links

• Official instructions for the drug Aevit.

Attention!
Description of the drug " Aevit"on this page is a simplified and expanded version official instructions by application. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.